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Preparation of Re-188-HEDP lyophilized kit for instant bone metastases therapy
Yang Zhi; Zhu Hua; Li Nan; Ma Yun-Xia; Zhang Yan
关键词Rhenium-188 Hydroxyethylidene diphosphonate Lyophilized kit Bone tumor therapy
刊名NUCLEAR SCIENCE AND TECHNIQUES
2014-12-01
25期:6
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Nuclear Science & Technology ; Physics, Nuclear
研究领域[WOS]Nuclear Science & Technology ; Physics
关键词[WOS]PROSTATE-CANCER PATIENTS ; OSSEOUS METASTASES ; HYDROXYETHYLIDENE DIPHOSPHONATE ; RADIONUCLIDE THERAPY ; PAIN PALLIATION ; RE-186 HEDP ; CARCINOMA ; STABILITY ; PURITY
英文摘要

Hydroxyethylidene diphosphonate (HEDP) was prepared and labeled with rhenium-188. Its lyophilized kit was developed for instant preparing of Re-188-HEDP. Re-188-HEDP showed high focile uptake in normal mice (> 30% ID/g at carrier co-injection) in BABLC/SPF mice. High quality single photon emission computed tomography (SPECT) image of New Zealand rabbit was obtained at 4 h after intravenous injection of 74 MBq radiotracer. The lyophilized HEDP kit affords the new opportunity for routine clinical application in bone metastases therapy.

语种英语
WOS记录号WOS:000348411100009
项目编号81071198 ; 81172083 ; 81371592 ; 7132040
资助机构National Natural Science Foundation of China ; Beijing Natural Science Foundation
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61244
专题北京大学临床肿瘤学院_核医学科
作者单位Peking Univ Canc Hosp & Inst, Dept Nucl Med, Key Lab Carcinogenesis & Translat Res, Minist Educ, Beijing 100142, Peoples R China
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GB/T 7714
Yang Zhi,Zhu Hua,Li Nan,et al. Preparation of Re-188-HEDP lyophilized kit for instant bone metastases therapy[J]. NUCLEAR SCIENCE AND TECHNIQUES,2014,25(6).
APA Yang Zhi,Zhu Hua,Li Nan,Ma Yun-Xia,&Zhang Yan.(2014).Preparation of Re-188-HEDP lyophilized kit for instant bone metastases therapy.NUCLEAR SCIENCE AND TECHNIQUES,25(6).
MLA Yang Zhi,et al."Preparation of Re-188-HEDP lyophilized kit for instant bone metastases therapy".NUCLEAR SCIENCE AND TECHNIQUES 25.6(2014).
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