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学科主题: 临床医学
题名:
Preparation of Re-188-HEDP lyophilized kit for instant bone metastases therapy
作者: Yang Zhi; Zhu Hua; Li Nan; Ma Yun-Xia; Zhang Yan
关键词: Rhenium-188 ; Hydroxyethylidene diphosphonate ; Lyophilized kit ; Bone tumor therapy
刊名: NUCLEAR SCIENCE AND TECHNIQUES
发表日期: 2014-12-01
卷: 25, 期:6
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Nuclear Science & Technology ; Physics, Nuclear
研究领域[WOS]: Nuclear Science & Technology ; Physics
关键词[WOS]: PROSTATE-CANCER PATIENTS ; OSSEOUS METASTASES ; HYDROXYETHYLIDENE DIPHOSPHONATE ; RADIONUCLIDE THERAPY ; PAIN PALLIATION ; RE-186 HEDP ; CARCINOMA ; STABILITY ; PURITY
英文摘要:

Hydroxyethylidene diphosphonate (HEDP) was prepared and labeled with rhenium-188. Its lyophilized kit was developed for instant preparing of Re-188-HEDP. Re-188-HEDP showed high focile uptake in normal mice (> 30% ID/g at carrier co-injection) in BABLC/SPF mice. High quality single photon emission computed tomography (SPECT) image of New Zealand rabbit was obtained at 4 h after intravenous injection of 74 MBq radiotracer. The lyophilized HEDP kit affords the new opportunity for routine clinical application in bone metastases therapy.

语种: 英语
所属项目编号: 81071198 ; 81172083 ; 81371592 ; 7132040
项目资助者: National Natural Science Foundation of China ; Beijing Natural Science Foundation
WOS记录号: WOS:000348411100009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61244
Appears in Collections:北京大学临床肿瘤学院_核医学科_期刊论文

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作者单位: Peking Univ Canc Hosp & Inst, Dept Nucl Med, Key Lab Carcinogenesis & Translat Res, Minist Educ, Beijing 100142, Peoples R China

Recommended Citation:
Yang Zhi,Zhu Hua,Li Nan,et al. Preparation of Re-188-HEDP lyophilized kit for instant bone metastases therapy[J]. NUCLEAR SCIENCE AND TECHNIQUES,2014,25(6).
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