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学科主题: 药学
题名:
Coplanar effect studies on the benzamides of dopamine D-2 receptor imaging agents
作者: Jia, HM; Meng, ZX; Liu, BL; Wang, W
关键词: benzamides ; dopamine D-2 receptor imaging agents ; coplanar effect
刊名: ACTA PHYSICO-CHIMICA SINICA
发表日期: 2000-05-01
DOI: 10.3866/PKU.WHXB20000521
卷: 16, 期:5, 页:476-480
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Physical
研究领域[WOS]: Chemistry
关键词[WOS]: POTENTIAL ANTIPSYCHOTIC AGENTS ; ANTIDOPAMINERGIC PROPERTIES ; NEUROLEPTIC AGENTS ; CHEMISTRY
英文摘要:

The structure-affinity correlations of a series of benzamides for dopamine D-2 receptor imaging agents have been studied with SYBYL 6.4 software on SGI O2 workstation, The results of conformational analysis and PM3 calculation have demonstrated that the coplanar effect of benzamides is one of the most important requirements for activity in vitro, The aromatic substituent in the 2 position is the main factor which influences the coplanar arrangement of pseudring (B) involving the amide moiety and the methoxy group relative to the aromatic ring, while the influences of other factors on this side such as the aromatic substituents in the 3 and 5 positions and the conformation of side chain may be neglected, The conclusion may be useful in understanding the interaction of D-2 receptor-ligand and designing new D-2 receptor ligands.

语种: 中文
WOS记录号: WOS:000087310500021
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61245
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Beijing Normal Univ, Dept Chem, Beijing 100875, Peoples R China
2.Beijing Med Univ, Sch Pharmaceut Sci, Beijing 100083, Peoples R China

Recommended Citation:
Jia, HM,Meng, ZX,Liu, BL,et al. Coplanar effect studies on the benzamides of dopamine D-2 receptor imaging agents[J]. ACTA PHYSICO-CHIMICA SINICA,2000,16(5):476-480.
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