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Coplanar effect studies on the benzamides of dopamine D-2 receptor imaging agents
Jia, HM; Meng, ZX; Liu, BL; Wang, W
关键词benzamides dopamine D-2 receptor imaging agents coplanar effect
刊名ACTA PHYSICO-CHIMICA SINICA
2000-05-01
DOI10.3866/PKU.WHXB20000521
16期:5页:476-480
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Physical
研究领域[WOS]Chemistry
关键词[WOS]POTENTIAL ANTIPSYCHOTIC AGENTS ; ANTIDOPAMINERGIC PROPERTIES ; NEUROLEPTIC AGENTS ; CHEMISTRY
英文摘要

The structure-affinity correlations of a series of benzamides for dopamine D-2 receptor imaging agents have been studied with SYBYL 6.4 software on SGI O2 workstation, The results of conformational analysis and PM3 calculation have demonstrated that the coplanar effect of benzamides is one of the most important requirements for activity in vitro, The aromatic substituent in the 2 position is the main factor which influences the coplanar arrangement of pseudring (B) involving the amide moiety and the methoxy group relative to the aromatic ring, while the influences of other factors on this side such as the aromatic substituents in the 3 and 5 positions and the conformation of side chain may be neglected, The conclusion may be useful in understanding the interaction of D-2 receptor-ligand and designing new D-2 receptor ligands.

语种中文
WOS记录号WOS:000087310500021
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61245
专题北京大学药学院
作者单位1.Beijing Normal Univ, Dept Chem, Beijing 100875, Peoples R China
2.Beijing Med Univ, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Jia, HM,Meng, ZX,Liu, BL,et al. Coplanar effect studies on the benzamides of dopamine D-2 receptor imaging agents[J]. ACTA PHYSICO-CHIMICA SINICA,2000,16(5):476-480.
APA Jia, HM,Meng, ZX,Liu, BL,&Wang, W.(2000).Coplanar effect studies on the benzamides of dopamine D-2 receptor imaging agents.ACTA PHYSICO-CHIMICA SINICA,16(5),476-480.
MLA Jia, HM,et al."Coplanar effect studies on the benzamides of dopamine D-2 receptor imaging agents".ACTA PHYSICO-CHIMICA SINICA 16.5(2000):476-480.
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