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学科主题: 药物依赖
题名:
Changes in functional connectivity of ventral anterior cingulate cortex in heroin abusers
作者: Wang Wei1; Wang Ya-rong2; Qin Wei3; Yuan Kai3; Tian Jie3; Li Qiang2; Yang Lan-ying2; Lu Lin4; Guo You-min1
关键词: heroin ; ventral anterior cingulate cortex (vACC) ; functional MRI
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2010-06-20
DOI: 10.3760/cma.j.issn.0366-6999.2010.12.019
卷: 123, 期:12, 页:1582-1588
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: EPISODIC MEMORY RETRIEVAL ; DEFAULT MODE NETWORK ; HUMAN BRAIN ; PREFRONTAL CORTEX ; WORKING-MEMORY ; DRUG-ADDICTION ; NEURAL BASIS ; COCAINE ; DYSFUNCTION ; TASK
英文摘要:

Background Previous studies with animal experiments, autopsy, structural magnetic resonance imaging (MRI) and task-related functional MRI (fMRI) have confirmed that brain functional connectivity in addicts has become impaired. The goal of this study was to investigate the alteration of resting-state functional connectivity of the ventral anterior cingulate cortex (vACC) in the heroin abusers′ brain.

Methods Fifteen heroin abusers and fifteen matched healthy volunteers were studied using vACC as the region-of interest (ROI) seed. A 3.0 T scanner with a standard head coil was the imagining apparatus. T2*-weighted gradient-echo planar imaging (GRE-EPI) was the scanning protocol. A ROI seed based correlation analysis used a SPM5 software package as the tool for all images processing.

Results This study showed a functional connection to the insula vACC in heroin abusers. Compared with controls, heroin users showed decreased functional connectivity between the nucleus accumbens (NAc) and vACC, between the parahippocampala gyrus/amgdala (PHC/amygdala) and vACC, between the thalamus and vACC, and between the posterior cingulated cortex/precuneus (PCC/pC) and vACC.

Conclusion The altered resting-state functional connectivity to the vACC suggests the neural circuitry on which the addictive drug has an affect and reflects the dysfunction of the addictive brain. Chin Med J 2010;123(12):1582-1588

语种: 英语
所属项目编号: 30870685 ; 2008k12-02
项目资助者: National Natural Science Foundation of China ; Shaanxi Province Science and Technology Development Projection
WOS记录号: WOS:000279754100019
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61254
Appears in Collections:中国药物依赖性研究所_期刊论文

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作者单位: 1.Xi An Jiao Tong Univ, Affiliated Hosp 1, Mol Imaging Ctr, Sch Med, Xian 710061, Shannxi, Peoples R China
2.Fourth Mil Med Univ, Dept Radiol, Tangdu Hosp, Xian 710038, Shaanxi, Peoples R China
3.Xidian Univ, Life Sci Res Ctr, Sch Elect Engn, Xian 710071, Shannxi, Peoples R China
4.Peking Univ, Natl Inst Drug Dependence, Beijing 100083, Peoples R China

Recommended Citation:
Wang Wei,Wang Ya-rong,Qin Wei,et al. Changes in functional connectivity of ventral anterior cingulate cortex in heroin abusers[J]. CHINESE MEDICAL JOURNAL,2010,123(12):1582-1588.
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