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学科主题: 临床医学
题名:
A comparative study on in vitro and in vivo effects of topical vasodilators in human internal mammary, radial artery and great saphenous vein
作者: Ding, Rongjing1,2,3; Feng, Wenhui1; Li, Hongwei1; Wang, Lei1; Li, Dalian1; Cheng, Zhiguang1; Guo, Jianzhong1; Hu, Dayi3
关键词: Coronary artery bypass grafting ; Vasospasm ; Diltiazem ; Nitroglycerin ; Urapidil ; Nicorandil
刊名: EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
发表日期: 2008-09-01
DOI: 10.1016/j.ejcts.2008.05.050
卷: 34, 期:3, 页:536-541
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cardiac & Cardiovascular Systems ; Respiratory System ; Surgery
研究领域[WOS]: Cardiovascular System & Cardiology ; Respiratory System ; Surgery
关键词[WOS]: BYPASS ; GRAFTS ; REVASCULARIZATION
英文摘要:

Objective: As an important prognostic factor of coronary artery bypass grafting (CABG), graft vasospasm can be observed in all currently used graft conduits. Radial artery (RA) vasospasm is more prone to occur in comparisons with internal mammary artery (IMA) and great saphenous vein (GSV). There is still controversy about which antispasmodic agent is superior to different grafts, especially to RA conduits. The aim of this pilot study was to investigate the relaxation response of four topical vasodilators to different in vitro grafts and how these vasodilators affect the blood flow of the vessel in situ during RA harvesting. Materials and methods: Vasodilatory properties of diltiazem, nitroglycerin, urapidil and nicorandil were compared in matched patient-specific segments of RA, IMA and GSV harvested from 12 patients. The vasodilatory response of the RA to intraradial administration of nitroglycerin, diltiazem and urapidil was compared in vivo (n = 10 per group) by assessing the free blood flow of RA. Results: (1) The maximal relaxations occurring with urapidil, nitroglycerin and nicorandil in IMA, RA and SGV were significantly greater than that with diltiazem. The reactivity of all three graft conduits showed similar relaxation with nitroglycerin or with diltiazem, but the relaxation with urapidil in RA showed greater than that of IMA and GSV, and RA and GSV showed greater relaxation with nicorandil than IMA. (2) A dose of 10(-5) mol/l of nitroglycerin, urapidil and nicorandil but not diltiazem significantly inhibited the RA response to PE. (3) In vivo, urapidil and nitroglycerin significantly increased the RA blood flow, the potency of which was greater than that caused by diltiazem. Conclusions: (1) Comparing with nicorandil, urapidil and diltiazem, nitroglycerin caused a significant relaxation in all three graft vessels tested. (2) Nitroglycerin, nicorandil and urapidil were more effective in preventing RA spasm than diltiazem. (C) 2008 European Association for Cardio-Thoracic Surgery. Published by Elsevier B.V. All rights reserved.

语种: 英语
WOS记录号: WOS:000259911900013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61260
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Capital Univ Med Sci, Ctr Heart, Beijing Friendship Hosp, Beijing, Peoples R China
2.Dalian Univ, Zhongshan Hosp, Dept Cardiol, Dalian, Peoples R China
3.Beijing Univ, Peoples Hosp, Ctr Heart, Beijing 100871, Peoples R China

Recommended Citation:
Ding, Rongjing,Feng, Wenhui,Li, Hongwei,et al. A comparative study on in vitro and in vivo effects of topical vasodilators in human internal mammary, radial artery and great saphenous vein[J]. EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY,2008,34(3):536-541.
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