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学科主题: 药学
题名:
Isobavachalcone and bavachinin from Psoraleae Fructus modulate A beta 42 aggregation process through different mechanisms in vitro
作者: Chen, Xiumin; Yang, Yanfang; Zhang, Yingtao
关键词: Psoraleae Fructus ; Isobavachalcone ; Bavachinin ; Amyloid beta ; Aggregation inhibitor
刊名: FEBS LETTERS
发表日期: 2013-09-17
DOI: 10.1016/j.febslet.2013.07.037
卷: 587, 期:18, 页:2930-2935
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
关键词[WOS]: ALZHEIMERS-DISEASE ; CORYLIFOLIA L. ; BETA ; OLIGOMERS ; PATHWAY ; POLYPHENOLS ; FINGERPRINT ; EXTRACT ; SEEDS ; RATS
英文摘要:

Spontaneous aggregation of A beta is a key factor in the development of Alzheimer′s disease. In searching for A beta aggregation inhibitors from traditional Chinese herbal medicines, we identified two active compounds from Psoraleae Fructus, namely isobavachalcone and bavachinin. We further demonstrated that the two compounds modulate A beta 42 aggregation process through different mechanisms. Isobavachalcone significantly inhibits both oligomerization and fibrillization of A beta 42, whereas bavachinin inhibits fibrillization and leads to off-pathway aggregation. Both of the compounds attenuated A beta 42-induced toxicity in a SH-SY5Y cell model. These findings may provide valuable information for new drug development and Alzheimer′s therapy in the future.

Structured digital abstract:

Abeta42 physically interacts with Abeta42 by two hybrid (View interaction)

Abeta42 and Abeta42 bind by filter binding (View interaction)

Abeta42 and Abeta42 bind by comigration in sds page (1, 2, 3)

Abeta42 and Abeta42 bind by atomic force microscopy (View interaction)

Abeta42 and Abeta42 bind by fluorescence technology (View interaction) (C) 2013 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

语种: 英语
所属项目编号: 7112090
项目资助者: Beijing Natural Science Foundation
WOS记录号: WOS:000324033700006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61261
Appears in Collections:北京大学药学院_期刊论文

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作者单位: Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

Recommended Citation:
Chen, Xiumin,Yang, Yanfang,Zhang, Yingtao. Isobavachalcone and bavachinin from Psoraleae Fructus modulate A beta 42 aggregation process through different mechanisms in vitro[J]. FEBS LETTERS,2013,587(18):2930-2935.
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