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Isobavachalcone and bavachinin from Psoraleae Fructus modulate A beta 42 aggregation process through different mechanisms in vitro
Chen, Xiumin; Yang, Yanfang; Zhang, Yingtao
关键词Psoraleae Fructus Isobavachalcone Bavachinin Amyloid beta Aggregation inhibitor
刊名FEBS LETTERS
2013-09-17
DOI10.1016/j.febslet.2013.07.037
587期:18页:2930-2935
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
资助者Beijing Natural Science Foundation ; Beijing Natural Science Foundation
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
关键词[WOS]ALZHEIMERS-DISEASE ; CORYLIFOLIA L. ; BETA ; OLIGOMERS ; PATHWAY ; POLYPHENOLS ; FINGERPRINT ; EXTRACT ; SEEDS ; RATS
英文摘要

Spontaneous aggregation of A beta is a key factor in the development of Alzheimer′s disease. In searching for A beta aggregation inhibitors from traditional Chinese herbal medicines, we identified two active compounds from Psoraleae Fructus, namely isobavachalcone and bavachinin. We further demonstrated that the two compounds modulate A beta 42 aggregation process through different mechanisms. Isobavachalcone significantly inhibits both oligomerization and fibrillization of A beta 42, whereas bavachinin inhibits fibrillization and leads to off-pathway aggregation. Both of the compounds attenuated A beta 42-induced toxicity in a SH-SY5Y cell model. These findings may provide valuable information for new drug development and Alzheimer′s therapy in the future.

Structured digital abstract:

Abeta42 physically interacts with Abeta42 by two hybrid (View interaction)

Abeta42 and Abeta42 bind by filter binding (View interaction)

Abeta42 and Abeta42 bind by comigration in sds page (1, 2, 3)

Abeta42 and Abeta42 bind by atomic force microscopy (View interaction)

Abeta42 and Abeta42 bind by fluorescence technology (View interaction) (C) 2013 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

语种英语
所属项目编号7112090
资助者Beijing Natural Science Foundation ; Beijing Natural Science Foundation
WOS记录号WOS:000324033700006
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61261
专题北京大学药学院
作者单位Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
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GB/T 7714
Chen, Xiumin,Yang, Yanfang,Zhang, Yingtao. Isobavachalcone and bavachinin from Psoraleae Fructus modulate A beta 42 aggregation process through different mechanisms in vitro[J]. FEBS LETTERS,2013,587(18):2930-2935.
APA Chen, Xiumin,Yang, Yanfang,&Zhang, Yingtao.(2013).Isobavachalcone and bavachinin from Psoraleae Fructus modulate A beta 42 aggregation process through different mechanisms in vitro.FEBS LETTERS,587(18),2930-2935.
MLA Chen, Xiumin,et al."Isobavachalcone and bavachinin from Psoraleae Fructus modulate A beta 42 aggregation process through different mechanisms in vitro".FEBS LETTERS 587.18(2013):2930-2935.
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