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学科主题: 药学
题名:
Effects of lanthanum on composition, crystal size, and lattice structure of femur bone mineral of Wistar rats
作者: Huang, J; Zhang, TL; Xu, SJ; Li, RC; Wang, K; Zhang, J; Xie, YN
关键词: lanthanum ; bone mineral ; crystal size ; lattice structure ; rat
刊名: CALCIFIED TISSUE INTERNATIONAL
发表日期: 2006-04-01
DOI: 10.1007/s00223-005-0294-2
卷: 78, 期:4, 页:241-247
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Endocrinology & Metabolism
研究领域[WOS]: Endocrinology & Metabolism
关键词[WOS]: X-RAY-SCATTERING ; MICROSPECTROSCOPIC ANALYSIS ; PHOSPHATE BINDER ; RENAL-FAILURE ; CARBONATE ; SPECTROSCOPY ; EXAFS ; IONS ; OVARIECTOMY ; TOXICITY
英文摘要:

The application of lanthanum (La) in industry, medicine, and agriculture may cause accumulation of the element in human body. This article examines the effects of La on the femur bone mineral of male Wistar rats after administration of La(NO3)(3) by gavage at the dose of 2.0 mg La(NO3)(3) center dot kg(-1) center dot day(-1) over a 6-month period. Chemical analysis confirmed La accumulation in bone and loss in bone mineral. Thermogravimetric analysis showed a decrease in the mineral-to-matrix ratio and an increase in carbonate content. Fourier-transform infrared spectrometry revealed elevation in the contents of labile carbonate and acidic phosphate. The synchrotron radiation small-angle X-ray scattering study presented a smaller mean thickness of the mineral crystals in the bone of La-treated rats. The synchrotron radiation-extended X-ray absorption fine structure analysis indicated that the La treatment resulted in a lowered disorder in the crystals. The smaller size, more adsorbed labile carbonate, and more acidic phosphate made the bone mineral easier to dissolve, as revealed in the kinetic measurement of bone demineralization. These findings suggest that La retards bone maturation of rats.

语种: 英语
WOS记录号: WOS:000236751000007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61269
Appears in Collections:北京大学药学院_化学生物学系_期刊论文

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作者单位: 1.Capital Univ Med Sci, Sch Pharmaceut Sci, Beijing 100054, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Dept Biol Chem, Beijing 100083, Peoples R China
3.Chinese Acad Sci, Lab Beijing Synchrotron Radiat, Inst High Energy Phys, Beijing 100039, Peoples R China

Recommended Citation:
Huang, J,Zhang, TL,Xu, SJ,et al. Effects of lanthanum on composition, crystal size, and lattice structure of femur bone mineral of Wistar rats[J]. CALCIFIED TISSUE INTERNATIONAL,2006,78(4):241-247.
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