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Role of the NO/sGC/PKG signaling pathway of hippocampal CA1 in morphine-induced reward memory
Shen, Fang; Li, Yi-Jing; Shou, Xiao-Jing; Cui, Cai-Lian1
关键词Nitric oxide signaling pathway Morphine Reward memory Hippocampal CA1 region
刊名NEUROBIOLOGY OF LEARNING AND MEMORY
2012-09-01
DOI10.1016/j.nlm.2012.07.005
98期:2页:130-138
收录类别SCI ; SSCI
文章类型Article
WOS标题词Science & Technology ; Social Sciences
类目[WOS]Behavioral Sciences ; Neurosciences ; Psychology ; Psychology, Multidisciplinary
研究领域[WOS]Behavioral Sciences ; Neurosciences & Neurology ; Psychology
关键词[WOS]CONDITIONED PLACE PREFERENCE ; LONG-TERM POTENTIATION ; NITRIC-OXIDE SYNTHASE ; GUANYLATE-CYCLASE ; PROTEIN-SYNTHESIS ; CONTEXTUAL MEMORY ; NUCLEUS-ACCUMBENS ; DRUG-ADDICTION ; CGMP ; 7-NITROINDAZOLE
英文摘要

Evidence suggests that the nitric oxide (NO)/soluble guanylyl cyclase (sGC)/cGMP dependent protein kinase (PKG) signaling pathway plays a key role in memory processing, but the actual participation of this signaling cascade in the hippocampal CA1 during morphine-induced reward memory remains unknown. In this study, we investigated the role of the NO/sGC/PKG signaling pathway in the CA1 on morphine-induced reward memory using a conditioned place preference (CPP) paradigm. We found that rats receiving an intraperitoneal (i.p.) injection of 4 mg/kg morphine exhibited CPP, whereas rats treated with only 0.2 mg/kg morphine failed to produce CPP. Intra-CA1 injection of the neuronal NO synthase (nNOS) inhibitor 7-NI, the sGC inhibitor ODQ or the PKG inhibitor Rp-8-Br-PET-cGMPS had no effect on the acquisition of CPP by 4 mg/kg morphine. Intra-CA1 injection of 7-NI blocked the consolidation of CPP induced by 4 mg/kg morphine, and this amnesic effect of 7-NI was mimicked by ODQ and Rp-8-Br-PET-cGMPS. Intra-CA1 injection of the NOS substrate L-arg or the sGC activator YC-1 with an ineffective dose of morphine (0.2 mg/kg, i.p.) elicited CPP. This response induced by L-arg or YC-1 was reversed by pre-microinjection of Rp-8-Br-PET-cGMPS in the CA1. These results indicated that the activation of the NO/sGC/PKG signaling pathway in the CA1 is necessary for the consolidation of morphine-related reward memory. (C) 2012 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000312356900004
项目编号30970933 ; 2009CB522003
资助机构National Natural Science Foundation ; National Basic Research Program
引用统计
被引频次:18[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61272
专题北京大学基础医学院_神经生物学系
北京大学基础医学院
作者单位1.Peking Univ, Neurosci Res Inst, Beijing 100191, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Dept Neurobiol, Beijing 100191, Peoples R China
3.Minist Educ, Key Lab Neurosci, Beijing 100191, Peoples R China
4.Minist Hlth, Beijing 100191, Peoples R China
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Shen, Fang,Li, Yi-Jing,Shou, Xiao-Jing,et al. Role of the NO/sGC/PKG signaling pathway of hippocampal CA1 in morphine-induced reward memory[J]. NEUROBIOLOGY OF LEARNING AND MEMORY,2012,98(2):130-138.
APA Shen, Fang,Li, Yi-Jing,Shou, Xiao-Jing,&Cui, Cai-Lian.(2012).Role of the NO/sGC/PKG signaling pathway of hippocampal CA1 in morphine-induced reward memory.NEUROBIOLOGY OF LEARNING AND MEMORY,98(2),130-138.
MLA Shen, Fang,et al."Role of the NO/sGC/PKG signaling pathway of hippocampal CA1 in morphine-induced reward memory".NEUROBIOLOGY OF LEARNING AND MEMORY 98.2(2012):130-138.
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