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学科主题: 基础医学
题名:
Identification of a mouse synaptic glycoprotein gene in cultured neurons
作者: Yu, ACH; Sun, CX; Li, Q; Liu, HD; Wang, CR; Zhao, GP; Jin, ML; Lau, LT; Fung, YWW; Liu, SA
关键词: primary culture ; cerebral cortical neurons ; synaptic glycoprotein ; bioinformatics
刊名: NEUROCHEMICAL RESEARCH
发表日期: 2005-10-01
DOI: 10.1007/s11064-005-8800-5
卷: 30, 期:10, 页:1289-1294
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Neurosciences
研究领域[WOS]: Biochemistry & Molecular Biology ; Neurosciences & Neurology
关键词[WOS]: EXTRACELLULAR-MATRIX GLYCOPROTEIN ; CEREBRAL CORTICAL-NEURONS ; MESSENGER-RNA ; DIFFERENTIAL DISPLAY ; MOLECULAR-CLONING ; TRANSCRIPTS ; ASTROCYTES ; GLUTAMATE ; SC1
英文摘要:

Neuronal differentiation and aging are known to involve many genes, which may also be differentially expressed during these developmental processes. From primary cultured cerebral cortical neurons, we have previously identified various differentially expressed gene transcripts from cultured cortical neurons using the technique of arbitrarily primed PCR (RAP-PCR). Among these transcripts, clone 0-2 was found to have high homology to rat and human synaptic glycoprotein. By in silico analysis using an EST database and the FACTURA software, the full-length sequence of 0-2 was assembled and the clone was named as mouse synaptic glycoprotein homolog 2 (mSC2). DNA sequencing revealed transcript size of mSC2 being smaller than the human and rat homologs. RT-PCR indicated that mSC2 was expressed differentially at various culture days. The mSC2 gene was located in various tissues with higher expression in brain, lung, and liver. Functions of mSC2 in neurons and other tissues remain elusive and will require more investigation.

语种: 英语
WOS记录号: WOS:000233866800010
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61274
Appears in Collections:基础医学院_神经生物学系_期刊论文

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作者单位: 1.Peking Univ, Neurosci Res Inst, Beijing 100871, Peoples R China
2.Minist Educ Res, Key Lab Neurosci, Beijing, Peoples R China
3.Peking Univ, Dept Neurobiol, Hlth Sci Ctr, Beijing 100871, Peoples R China
4.Chinese Acad Sci, Shanghai Brain Res Inst, Shanghai Res Ctr Life Sci, Shanghai, Peoples R China
5.Hong Kong DNA Chips Ltd, Hong Kong, Hong Kong, Peoples R China
6.Chinese Acad Sci, Shanghai Res Ctr Biotechnol, Shanghai Inst Biol Sci, Shanghai, Peoples R China

Recommended Citation:
Yu, ACH,Sun, CX,Li, Q,et al. Identification of a mouse synaptic glycoprotein gene in cultured neurons[J]. NEUROCHEMICAL RESEARCH,2005,30(10):1289-1294.
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