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学科主题: 临床医学
题名:
Analysis of the Associations between Vitamin D and Albuminuria or beta-Cell Function in Chinese Type 2 Diabetes
作者: Cai, Xiaoling; Hu, Zhaoheng; Chen, Ling; Han, Xueyao; Ji, Linong
刊名: BIOMED RESEARCH INTERNATIONAL
发表日期: 2014
DOI: 10.1155/2014/640909
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biotechnology & Applied Microbiology ; Medicine, Research & Experimental
研究领域[WOS]: Biotechnology & Applied Microbiology ; Research & Experimental Medicine
关键词[WOS]: CYTOSOLIC FREE CALCIUM ; NUTRITION EXAMINATION SURVEY ; MIDDLE-AGED MEN ; D DEFICIENCY ; INSULIN-RESISTANCE ; GLUCAGON-SECRETION ; GLUCOSE-TOLERANCE ; NATIONAL-HEALTH ; BLOOD-PRESSURE ; US ADULTS
英文摘要:

Objective. To investigate the associations of 25-(OH) D and beta-cell function or insulin resistance or albuminuria in Chinese type 2 diabetic patients. Methods. In total, 1408 type 2 diabetic patients without vitamin D supplement were included in this retrospective study. Results. Comparison between patients with and without 25-(OH) D deficiency indicated that, compared with patients with 25-(OH) D >= 50 nmol/L, patients with 25-(OH) D < 50 nmol/L showed a higher level of urine albumin-creatinine ratio (ACR) (90.15 +/- 10.30 mg/g versus 52.79 +/- 14.97mg/g). Multiple regression analysis indicated that 25-(OH) D was independently and negatively correlated with urine ACR (OR = 0.985, 95% CI 0.972-0.999, P = 0.03), adjusted by age, diabetic duration, HBP duration, SBP, HbA1c, creatinine, LDL-C, triglyceride, total cholesterol, and HDL-C. Compared with patients with normal level of urine ACR, patients with higher level of urine ACR showed a significant lower level of 25-(OH) D (34.49 +/- 13.52 nmol/L versus 37.46 +/- 13.6 nmol/L, P = 0.00). Analysis of the associations of 25-(OH) D and beta-cell function or insulin resistance showed that 25-(OH) D may not correlate with beta-cell function or insulin resistance. Conclusion. 25-(OH) D was independently associated with albuminuria in Chinese type 2 diabetic patients but was not associated with beta-cell function or insulin resistance.

语种: 英语
WOS记录号: WOS:000335239300001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61275
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: Peking Univ, Peoples Hosp, Endocrine & Metab Dept, Beijing 100044, Peoples R China

Recommended Citation:
Cai, Xiaoling,Hu, Zhaoheng,Chen, Ling,et al. Analysis of the Associations between Vitamin D and Albuminuria or beta-Cell Function in Chinese Type 2 Diabetes[J]. BIOMED RESEARCH INTERNATIONAL,2014.
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