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Analysis of the Associations between Vitamin D and Albuminuria or beta-Cell Function in Chinese Type 2 Diabetes
Cai, Xiaoling; Hu, Zhaoheng; Chen, Ling; Han, Xueyao; Ji, Linong
刊名BIOMED RESEARCH INTERNATIONAL
2014
DOI10.1155/2014/640909
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biotechnology & Applied Microbiology ; Medicine, Research & Experimental
研究领域[WOS]Biotechnology & Applied Microbiology ; Research & Experimental Medicine
关键词[WOS]CYTOSOLIC FREE CALCIUM ; NUTRITION EXAMINATION SURVEY ; MIDDLE-AGED MEN ; D DEFICIENCY ; INSULIN-RESISTANCE ; GLUCAGON-SECRETION ; GLUCOSE-TOLERANCE ; NATIONAL-HEALTH ; BLOOD-PRESSURE ; US ADULTS
英文摘要

Objective. To investigate the associations of 25-(OH) D and beta-cell function or insulin resistance or albuminuria in Chinese type 2 diabetic patients. Methods. In total, 1408 type 2 diabetic patients without vitamin D supplement were included in this retrospective study. Results. Comparison between patients with and without 25-(OH) D deficiency indicated that, compared with patients with 25-(OH) D >= 50 nmol/L, patients with 25-(OH) D < 50 nmol/L showed a higher level of urine albumin-creatinine ratio (ACR) (90.15 +/- 10.30 mg/g versus 52.79 +/- 14.97mg/g). Multiple regression analysis indicated that 25-(OH) D was independently and negatively correlated with urine ACR (OR = 0.985, 95% CI 0.972-0.999, P = 0.03), adjusted by age, diabetic duration, HBP duration, SBP, HbA1c, creatinine, LDL-C, triglyceride, total cholesterol, and HDL-C. Compared with patients with normal level of urine ACR, patients with higher level of urine ACR showed a significant lower level of 25-(OH) D (34.49 +/- 13.52 nmol/L versus 37.46 +/- 13.6 nmol/L, P = 0.00). Analysis of the associations of 25-(OH) D and beta-cell function or insulin resistance showed that 25-(OH) D may not correlate with beta-cell function or insulin resistance. Conclusion. 25-(OH) D was independently associated with albuminuria in Chinese type 2 diabetic patients but was not associated with beta-cell function or insulin resistance.

语种英语
WOS记录号WOS:000335239300001
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61275
专题北京大学第二临床医学院
北京大学第二临床医学院_内分泌科
作者单位Peking Univ, Peoples Hosp, Endocrine & Metab Dept, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Cai, Xiaoling,Hu, Zhaoheng,Chen, Ling,et al. Analysis of the Associations between Vitamin D and Albuminuria or beta-Cell Function in Chinese Type 2 Diabetes[J]. BIOMED RESEARCH INTERNATIONAL,2014.
APA Cai, Xiaoling,Hu, Zhaoheng,Chen, Ling,Han, Xueyao,&Ji, Linong.(2014).Analysis of the Associations between Vitamin D and Albuminuria or beta-Cell Function in Chinese Type 2 Diabetes.BIOMED RESEARCH INTERNATIONAL.
MLA Cai, Xiaoling,et al."Analysis of the Associations between Vitamin D and Albuminuria or beta-Cell Function in Chinese Type 2 Diabetes".BIOMED RESEARCH INTERNATIONAL (2014).
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