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学科主题基础医学
Thiazolidinediones, a class of anti-diabetic drugs, inhibit Id2 expression through a PPAR gamma independent pathway in human aortic smooth muscle cells
Zhu, X; Lin, Y; Zhang, J; Fu, M; Mao, Z; Chen, YE
关键词diabetes atherosclerosis vascular smooth muscle cell proliferation gene expression
刊名CELLULAR AND MOLECULAR LIFE SCIENCES
2003
60期:1页:212-218
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Cell Biology
研究领域[WOS]Biochemistry & Molecular Biology ; Cell Biology
关键词[WOS]LOOP-HELIX PROTEINS ; INSULIN-RESISTANCE ; GENE-EXPRESSION ; GROWTH ; DIFFERENTIATION ; PROLIFERATION ; RAT
英文摘要

Inhibitor of DNA binding (Id2) is a member of the helix-loop-helix family of transcription regulators that is known to play important roles in the proliferation and differentiation of many cell types. Overexpression of Id2 has been reported to result in significant enhancement of vascular smooth muscle cell growth via increased S phase entry. We hypothesized that downregulation of Id2 gene expression by thiazolidinediones (TZDs), a class of anti-diabetic drugs and peroxisome proliferator-activated receptor gamma (PPARgamma) activators, might contribute to the anti-atherosclerotic and anti-hypertensive effects of the PPARgamma. Here we document that TZDs, including troglitazone and ciglitazone, repress Id2 gene expression in a doses- and time-dependent manner. However, GW7845, a high-affinity and non-TZD PPARgamma activator, had no inhibitory effect on Id2 gene expression. In addition, PPARgamma antagonist GW9662 did not rescue TZD-induced Id2 repression. Taken together, our data suggest that TZDs repress Id2 expression through a PPARgamma-independent pathway.

语种英语
WOS记录号WOS:000181638100016
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61278
专题北京大学基础医学院_心血管所
作者单位1.Peking Univ, Hlth Sci Ctr, Cardiovasc Res Inst, Beijing 100083, Peoples R China
2.Morehouse Sch Med, Cardiovasc Res Inst, Atlanta, GA 30310 USA
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GB/T 7714
Zhu, X,Lin, Y,Zhang, J,et al. Thiazolidinediones, a class of anti-diabetic drugs, inhibit Id2 expression through a PPAR gamma independent pathway in human aortic smooth muscle cells[J]. CELLULAR AND MOLECULAR LIFE SCIENCES,2003,60(1):212-218.
APA Zhu, X,Lin, Y,Zhang, J,Fu, M,Mao, Z,&Chen, YE.(2003).Thiazolidinediones, a class of anti-diabetic drugs, inhibit Id2 expression through a PPAR gamma independent pathway in human aortic smooth muscle cells.CELLULAR AND MOLECULAR LIFE SCIENCES,60(1),212-218.
MLA Zhu, X,et al."Thiazolidinediones, a class of anti-diabetic drugs, inhibit Id2 expression through a PPAR gamma independent pathway in human aortic smooth muscle cells".CELLULAR AND MOLECULAR LIFE SCIENCES 60.1(2003):212-218.
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