北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 基础医学院  > 心血管所  > 期刊论文
学科主题: 基础医学
题名:
Thiazolidinediones, a class of anti-diabetic drugs, inhibit Id2 expression through a PPAR gamma independent pathway in human aortic smooth muscle cells
作者: Zhu, X; Lin, Y; Zhang, J; Fu, M; Mao, Z; Chen, YE
关键词: diabetes ; atherosclerosis ; vascular smooth muscle cell ; proliferation ; gene expression
刊名: CELLULAR AND MOLECULAR LIFE SCIENCES
发表日期: 2003
卷: 60, 期:1, 页:212-218
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Cell Biology
研究领域[WOS]: Biochemistry & Molecular Biology ; Cell Biology
关键词[WOS]: LOOP-HELIX PROTEINS ; INSULIN-RESISTANCE ; GENE-EXPRESSION ; GROWTH ; DIFFERENTIATION ; PROLIFERATION ; RAT
英文摘要:

Inhibitor of DNA binding (Id2) is a member of the helix-loop-helix family of transcription regulators that is known to play important roles in the proliferation and differentiation of many cell types. Overexpression of Id2 has been reported to result in significant enhancement of vascular smooth muscle cell growth via increased S phase entry. We hypothesized that downregulation of Id2 gene expression by thiazolidinediones (TZDs), a class of anti-diabetic drugs and peroxisome proliferator-activated receptor gamma (PPARgamma) activators, might contribute to the anti-atherosclerotic and anti-hypertensive effects of the PPARgamma. Here we document that TZDs, including troglitazone and ciglitazone, repress Id2 gene expression in a doses- and time-dependent manner. However, GW7845, a high-affinity and non-TZD PPARgamma activator, had no inhibitory effect on Id2 gene expression. In addition, PPARgamma antagonist GW9662 did not rescue TZD-induced Id2 repression. Taken together, our data suggest that TZDs repress Id2 expression through a PPARgamma-independent pathway.

语种: 英语
WOS记录号: WOS:000181638100016
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61278
Appears in Collections:基础医学院_心血管所_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Hlth Sci Ctr, Cardiovasc Res Inst, Beijing 100083, Peoples R China
2.Morehouse Sch Med, Cardiovasc Res Inst, Atlanta, GA 30310 USA

Recommended Citation:
Zhu, X,Lin, Y,Zhang, J,et al. Thiazolidinediones, a class of anti-diabetic drugs, inhibit Id2 expression through a PPAR gamma independent pathway in human aortic smooth muscle cells[J]. CELLULAR AND MOLECULAR LIFE SCIENCES,2003,60(1):212-218.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Zhu, X]'s Articles
[Lin, Y]'s Articles
[Zhang, J]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Zhu, X]‘s Articles
[Lin, Y]‘s Articles
[Zhang, J]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace