IR@PKUHSC  > 北京大学口腔医学院  > 口腔病理科
学科主题口腔医学
Basaloid squamous cell carcinoma of the esophagus with or without adenoid cystic features
Li, TJ; Zhang, YX; Wen, J; Cowan, DF; Hart, J; Xiao, SY
刊名ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
2004-10-01
128期:10页:1124-1130
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medical Laboratory Technology ; Medicine, Research & Experimental ; Pathology
研究领域[WOS]Medical Laboratory Technology ; Research & Experimental Medicine ; Pathology
关键词[WOS]DIFFERENTIATION ; DIAGNOSIS ; CANCER ; P53
英文摘要

Context.-Basaloid squamous cell carcinoma (BSCC) of the esophagus is a rare malignant tumor that morphologically could bear some resemblance to adenoid cystic carcinoma (ACC) originating from salivary glands.

Objective.-The purpose of this study is to describe the histologic, immunohistochemical, and ultrastructural findings of BSCCs of the esophagus, with an emphasis on comparing tumors with or without adenoid cystic features.

Design.-We reviewed 239 cases of primary esophageal carcinoma and detected 12 cases (5%) of BSCC. The light and electron microscopic findings and immunocytochemical localization of various antigens, including cytokeratins (AE1, AE3), carcinoembryonic antigen, epithelial membrane antigen, S100, smooth muscle actin, and p53, were examined in these BSCC cases.

Results.-Histologically, all BSCCs were composed of solid lobules or nests of basaloid cells with well-demarcated outlines surrounded by a fibrous stroma. Seven of 12 tumors showed areas of ACC-like features, that is, cribriform-like pseudoglandular lumina formation and hyaline material surrounding the tumor nests, whereas the remaining 5 tumors were apparently pure basaloid carcinomas. These 2 groups of tumors were histologically and immunohistochemically identical in many aspects, namely, high-grade nuclei of the tumor cells with frequent mitoses, abundant comedo-type necrosis, focal areas of concomitant squamous differentiation, consistent immunoreactivity for cytokeratins, and poor or absent staining for S100 and smooth muscle actin. Ultrastructurally, the basaloid tumor cells exhibited relatively undifferentiated cellular characteristics and undeveloped cell organelles.

Conclusion.-Basaloid squamous cell carcinomas of the esophagus frequently have an intimate association with ACC-like patterns, but their histologic, immunocytochemical, and ultrastructural features correspond more to poorly differentiated squamous cell carcinoma than to salivary gland ACC. This distinction is important because genuine ACC is much less aggressive than BSCC.

语种英语
WOS记录号WOS:000224219500007
Citation statistics
Cited Times:22[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61282
Collection北京大学口腔医学院_口腔病理科
作者单位1.Univ Texas, Med Branch, Dept Pathol, Galveston, TX 77550 USA
2.Peking Univ, Sch Stomatol, Dept Oral Pathol, Beijing 100871, Peoples R China
3.Univ Chicago Hosp, Dept Pathol, Chicago, IL 60637 USA
Recommended Citation
GB/T 7714
Li, TJ,Zhang, YX,Wen, J,et al. Basaloid squamous cell carcinoma of the esophagus with or without adenoid cystic features[J]. ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE,2004,128(10):1124-1130.
APA Li, TJ,Zhang, YX,Wen, J,Cowan, DF,Hart, J,&Xiao, SY.(2004).Basaloid squamous cell carcinoma of the esophagus with or without adenoid cystic features.ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE,128(10),1124-1130.
MLA Li, TJ,et al."Basaloid squamous cell carcinoma of the esophagus with or without adenoid cystic features".ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE 128.10(2004):1124-1130.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
谷歌学术
谷歌学术Similar articles in
[Li, TJ]'s Articles
[Zhang, YX]'s Articles
[Wen, J]'s Articles
百度学术
百度学术Similar articles in
[Li, TJ]'s Articles
[Zhang, YX]'s Articles
[Wen, J]'s Articles
必应学术
必应学术Similar articles in
[Li, TJ]'s Articles
[Zhang, YX]'s Articles
[Wen, J]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.