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Basaloid squamous cell carcinoma of the esophagus with or without adenoid cystic features
Li, TJ; Zhang, YX; Wen, J; Cowan, DF; Hart, J; Xiao, SY
WOS标题词Science & Technology
类目[WOS]Medical Laboratory Technology ; Medicine, Research & Experimental ; Pathology
研究领域[WOS]Medical Laboratory Technology ; Research & Experimental Medicine ; Pathology

Context.-Basaloid squamous cell carcinoma (BSCC) of the esophagus is a rare malignant tumor that morphologically could bear some resemblance to adenoid cystic carcinoma (ACC) originating from salivary glands.

Objective.-The purpose of this study is to describe the histologic, immunohistochemical, and ultrastructural findings of BSCCs of the esophagus, with an emphasis on comparing tumors with or without adenoid cystic features.

Design.-We reviewed 239 cases of primary esophageal carcinoma and detected 12 cases (5%) of BSCC. The light and electron microscopic findings and immunocytochemical localization of various antigens, including cytokeratins (AE1, AE3), carcinoembryonic antigen, epithelial membrane antigen, S100, smooth muscle actin, and p53, were examined in these BSCC cases.

Results.-Histologically, all BSCCs were composed of solid lobules or nests of basaloid cells with well-demarcated outlines surrounded by a fibrous stroma. Seven of 12 tumors showed areas of ACC-like features, that is, cribriform-like pseudoglandular lumina formation and hyaline material surrounding the tumor nests, whereas the remaining 5 tumors were apparently pure basaloid carcinomas. These 2 groups of tumors were histologically and immunohistochemically identical in many aspects, namely, high-grade nuclei of the tumor cells with frequent mitoses, abundant comedo-type necrosis, focal areas of concomitant squamous differentiation, consistent immunoreactivity for cytokeratins, and poor or absent staining for S100 and smooth muscle actin. Ultrastructurally, the basaloid tumor cells exhibited relatively undifferentiated cellular characteristics and undeveloped cell organelles.

Conclusion.-Basaloid squamous cell carcinomas of the esophagus frequently have an intimate association with ACC-like patterns, but their histologic, immunocytochemical, and ultrastructural features correspond more to poorly differentiated squamous cell carcinoma than to salivary gland ACC. This distinction is important because genuine ACC is much less aggressive than BSCC.

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作者单位1.Univ Texas, Med Branch, Dept Pathol, Galveston, TX 77550 USA
2.Peking Univ, Sch Stomatol, Dept Oral Pathol, Beijing 100871, Peoples R China
3.Univ Chicago Hosp, Dept Pathol, Chicago, IL 60637 USA
Recommended Citation
GB/T 7714
Li, TJ,Zhang, YX,Wen, J,et al. Basaloid squamous cell carcinoma of the esophagus with or without adenoid cystic features[J]. ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE,2004,128(10):1124-1130.
APA Li, TJ,Zhang, YX,Wen, J,Cowan, DF,Hart, J,&Xiao, SY.(2004).Basaloid squamous cell carcinoma of the esophagus with or without adenoid cystic features.ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE,128(10),1124-1130.
MLA Li, TJ,et al."Basaloid squamous cell carcinoma of the esophagus with or without adenoid cystic features".ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE 128.10(2004):1124-1130.
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