学科主题基础医学
Perilipin Gene 1237 T > C Polymorphism is not Associated with Obesity Risk in Northern Chinese Han Adults
Hu, Dong-Sheng1; Xie, Jing2; Yu, Da-Hai3,4,5,6; Xu, Guo-Heng7; Lu, Jie1; Yang, Jin-Xiu1; Li, Chun-Yang1; Li, Yan-Yan1
关键词Perilipin Polymorphism Obesity
刊名BIOMEDICAL AND ENVIRONMENTAL SCIENCES
2009-10-01
22期:5页:442-447
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Environmental Sciences ; Public, Environmental & Occupational Health
研究领域[WOS]Environmental Sciences & Ecology ; Public, Environmental & Occupational Health
关键词[WOS]HUMAN ADIPOSE-TISSUE ; 11482G-GREATER-THAN-A POLYMORPHISM ; ADIPOCYTE LIPOLYSIS ; WEIGHT-LOSS ; LOCUS ; PLIN ; POPULATION ; RESISTANCE ; HAPLOTYPE ; PROTEINS
英文摘要

Objective To identify the association between PLIN 1237 polymorphism and obesity in Chinese Han adults. Methods A total of 994 adults (157 obese subjects, 322 overweight subjects, and 515 normal controls) were recruited from two rural communities. PLIN 1237 polymorphism was genotyped by polymerase chain reaction-restriction-fragment-length-polymorphism (PCR-PFLP). Association between PLIN polymorphisms and obesity status was estimated by ordinal logistic regression. Results The three genotypes of PLIN 1237 were detected with a percentage of 54.3%, 37.1%, and 8.6% in TT, TC, and CC genotypes, respectively. For the PLIN 1237 polymorphism locus, the frequency of alleles T and C was 0.73 and 0.27, respectively. The PLIN 1237 polymorphisms were in Hardy-Weinberg equilibrium. PLIN 1237 polymorphism was not associated with obesity. The odds ratio for overweight or obesity for the CC+TC genotype was 0.8 (0.4, 1.4) in women (P=0.4) and 0.6 (0.3, 1.3) in men (P=0.2) after adjustment for age, education, household income and alcohol consumption, smoking, and physical activity. Conclusion Chinese Han adults have a lower frequency of variant-allele C in PLIN 1237. PLIN 1237 T>C polymorphism is not significantly associated with obesity in northern Chinese adults.

语种英语
WOS记录号WOS:000271914300012
项目编号30671805 ; 2006KYCX010
资助机构National Science Foundation of China ; Henan Innovation Project for University Prominent Research Talents
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61290
专题北京大学基础医学院_生理学与病理生理学系
北京大学基础医学院
作者单位1.Peking Union Med Coll, Beijing 100037, Peoples R China
2.Zhengzhou Univ, Coll Publ Hlth, Dept Epidemiol, Zhengzhou 450001, Henan, Peoples R China
3.Univ Melbourne, Ctr Eye Res Australia, Populat Hlth Unit, Level 1, Melbourne, Vic 3002, Australia
4.Chinese Acad Med Sci, Dept Evidence Based Med, Beijing 100037, Peoples R China
5.Chinese Acad Med Sci, Div Populat Genet, Cardiovasc Inst, Beijing 100037, Peoples R China
6.Chinese Acad Med Sci, Fuwai Hosp, Beijing 100037, Peoples R China
7.Beijing Univ, Dept Physiol, Med Sci Ctr, Beijing 100083, Peoples R China
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GB/T 7714
Hu, Dong-Sheng,Xie, Jing,Yu, Da-Hai,et al. Perilipin Gene 1237 T > C Polymorphism is not Associated with Obesity Risk in Northern Chinese Han Adults[J]. BIOMEDICAL AND ENVIRONMENTAL SCIENCES,2009,22(5):442-447.
APA Hu, Dong-Sheng.,Xie, Jing.,Yu, Da-Hai.,Xu, Guo-Heng.,Lu, Jie.,...&Li, Yan-Yan.(2009).Perilipin Gene 1237 T > C Polymorphism is not Associated with Obesity Risk in Northern Chinese Han Adults.BIOMEDICAL AND ENVIRONMENTAL SCIENCES,22(5),442-447.
MLA Hu, Dong-Sheng,et al."Perilipin Gene 1237 T > C Polymorphism is not Associated with Obesity Risk in Northern Chinese Han Adults".BIOMEDICAL AND ENVIRONMENTAL SCIENCES 22.5(2009):442-447.
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