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学科主题: 公共卫生
题名:
Effect of milk tripeptides on blood pressure: A meta-analysis of randomized controlled trials
作者: Xu, Jia-Ying2; Qin, Li-Qiang2; Wang, Pei-Yu1; Li, Wei2; Chang, Chun1
关键词: milk ; tripeptide ; blood pressure ; hypertension ; meta-analysis
刊名: NUTRITION
发表日期: 2008-10-01
DOI: 10.1016/j.nut.2008.04.004
卷: 24, 期:10, 页:933-940
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Nutrition & Dietetics
研究领域[WOS]: Nutrition & Dietetics
关键词[WOS]: SPONTANEOUSLY HYPERTENSIVE RATS ; CONVERTING ENZYME-INHIBITORS ; HYDROLYSATE C-12 PEPTIDE ; JOINT NATIONAL COMMITTEE ; SOUR MILK ; FERMENTED MILK ; LACTOBACILLUS-HELVETICUS ; CASEIN HYDROLYSATE ; CLINICAL-TRIALS ; ANTIHYPERTENSIVE PEPTIDES
英文摘要:

Objective: To better understand and summarize the relation between milk peptide intake and blood pressure (BP), we conducted a meta-analysis of randomized controlled trials to assess the effects of the milk-derived tripeptides isoleucine-proline-proline and valine-proline-proline on BP in prehypertensive and hypertensive subjects.

Methods: Nine studies including 12 trials published between 1996 and 2005 with a total of 623 participants were included. Two researchers independently extracted data from the original publications. A fixed-effects model was used for meta-analysis because of the homogeneity among trials.

Results: Significant decreases of 4.8 mmHg (95% confidence interval 3.7-6.0) in systolic BP and 2.2 mmHg (95% confidence interval 1.3-3.1) in diastolic BP were found after the pooling of these trials. When trials were separated by BP status, hypotensive effects appeared to be larger in hypertensive subjects than in prehypertensive subjects. As a trend, the hypotensive effects became more obvious as the intervention lengthened.

Conclusion: Our analysis provided evidence that milk-derived tripeptides have hypotensive effects in prehypertensive and hypertensive subjects. (C) 2008 Elsevier Inc. All rights reserved.

语种: 英语
所属项目编号: 30771808 ; EE126712
项目资助者: National Natural Science Foundation of China ; Medical Developmental Foundation of Soochow University
WOS记录号: WOS:000259535200002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61294
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Peking Univ, Sch Publ Hlth, Dept Social Med & Hlth Educ, Beijing 100871, Peoples R China
2.Soochow Univ, Sch Radiat Med & Publ Hlth, Suzhou, Peoples R China

Recommended Citation:
Xu, Jia-Ying,Qin, Li-Qiang,Wang, Pei-Yu,et al. Effect of milk tripeptides on blood pressure: A meta-analysis of randomized controlled trials[J]. NUTRITION,2008,24(10):933-940.
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