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Effect of milk tripeptides on blood pressure: A meta-analysis of randomized controlled trials
Xu, Jia-Ying2; Qin, Li-Qiang2; Wang, Pei-Yu1; Li, Wei2; Chang, Chun1
关键词milk tripeptide blood pressure hypertension meta-analysis
刊名NUTRITION
2008-10-01
DOI10.1016/j.nut.2008.04.004
24期:10页:933-940
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Nutrition & Dietetics
资助者National Natural Science Foundation of China ; Medical Developmental Foundation of Soochow University ; National Natural Science Foundation of China ; Medical Developmental Foundation of Soochow University
研究领域[WOS]Nutrition & Dietetics
关键词[WOS]SPONTANEOUSLY HYPERTENSIVE RATS ; CONVERTING ENZYME-INHIBITORS ; HYDROLYSATE C-12 PEPTIDE ; JOINT NATIONAL COMMITTEE ; SOUR MILK ; FERMENTED MILK ; LACTOBACILLUS-HELVETICUS ; CASEIN HYDROLYSATE ; CLINICAL-TRIALS ; ANTIHYPERTENSIVE PEPTIDES
英文摘要

Objective: To better understand and summarize the relation between milk peptide intake and blood pressure (BP), we conducted a meta-analysis of randomized controlled trials to assess the effects of the milk-derived tripeptides isoleucine-proline-proline and valine-proline-proline on BP in prehypertensive and hypertensive subjects.

Methods: Nine studies including 12 trials published between 1996 and 2005 with a total of 623 participants were included. Two researchers independently extracted data from the original publications. A fixed-effects model was used for meta-analysis because of the homogeneity among trials.

Results: Significant decreases of 4.8 mmHg (95% confidence interval 3.7-6.0) in systolic BP and 2.2 mmHg (95% confidence interval 1.3-3.1) in diastolic BP were found after the pooling of these trials. When trials were separated by BP status, hypotensive effects appeared to be larger in hypertensive subjects than in prehypertensive subjects. As a trend, the hypotensive effects became more obvious as the intervention lengthened.

Conclusion: Our analysis provided evidence that milk-derived tripeptides have hypotensive effects in prehypertensive and hypertensive subjects. (C) 2008 Elsevier Inc. All rights reserved.

语种英语
所属项目编号30771808 ; EE126712
资助者National Natural Science Foundation of China ; Medical Developmental Foundation of Soochow University ; National Natural Science Foundation of China ; Medical Developmental Foundation of Soochow University
WOS记录号WOS:000259535200002
引用统计
被引频次:109[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61294
专题北京大学公共卫生学院
作者单位1.Peking Univ, Sch Publ Hlth, Dept Social Med & Hlth Educ, Beijing 100871, Peoples R China
2.Soochow Univ, Sch Radiat Med & Publ Hlth, Suzhou, Peoples R China
推荐引用方式
GB/T 7714
Xu, Jia-Ying,Qin, Li-Qiang,Wang, Pei-Yu,et al. Effect of milk tripeptides on blood pressure: A meta-analysis of randomized controlled trials[J]. NUTRITION,2008,24(10):933-940.
APA Xu, Jia-Ying,Qin, Li-Qiang,Wang, Pei-Yu,Li, Wei,&Chang, Chun.(2008).Effect of milk tripeptides on blood pressure: A meta-analysis of randomized controlled trials.NUTRITION,24(10),933-940.
MLA Xu, Jia-Ying,et al."Effect of milk tripeptides on blood pressure: A meta-analysis of randomized controlled trials".NUTRITION 24.10(2008):933-940.
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