|Effect of milk tripeptides on blood pressure: A meta-analysis of randomized controlled trials|
|Xu, Jia-Ying2; Qin, Li-Qiang2; Wang, Pei-Yu1; Li, Wei2; Chang, Chun1|
|关键词||milk tripeptide blood pressure hypertension meta-analysis|
|WOS标题词||Science & Technology|
|类目[WOS]||Nutrition & Dietetics|
|研究领域[WOS]||Nutrition & Dietetics|
|关键词[WOS]||SPONTANEOUSLY HYPERTENSIVE RATS ; CONVERTING ENZYME-INHIBITORS ; HYDROLYSATE C-12 PEPTIDE ; JOINT NATIONAL COMMITTEE ; SOUR MILK ; FERMENTED MILK ; LACTOBACILLUS-HELVETICUS ; CASEIN HYDROLYSATE ; CLINICAL-TRIALS ; ANTIHYPERTENSIVE PEPTIDES|
Objective: To better understand and summarize the relation between milk peptide intake and blood pressure (BP), we conducted a meta-analysis of randomized controlled trials to assess the effects of the milk-derived tripeptides isoleucine-proline-proline and valine-proline-proline on BP in prehypertensive and hypertensive subjects.
Methods: Nine studies including 12 trials published between 1996 and 2005 with a total of 623 participants were included. Two researchers independently extracted data from the original publications. A fixed-effects model was used for meta-analysis because of the homogeneity among trials.
Results: Significant decreases of 4.8 mmHg (95% confidence interval 3.7-6.0) in systolic BP and 2.2 mmHg (95% confidence interval 1.3-3.1) in diastolic BP were found after the pooling of these trials. When trials were separated by BP status, hypotensive effects appeared to be larger in hypertensive subjects than in prehypertensive subjects. As a trend, the hypotensive effects became more obvious as the intervention lengthened.
Conclusion: Our analysis provided evidence that milk-derived tripeptides have hypotensive effects in prehypertensive and hypertensive subjects. (C) 2008 Elsevier Inc. All rights reserved.
|项目编号||30771808 ; EE126712|
|资助机构||National Natural Science Foundation of China ; Medical Developmental Foundation of Soochow University|
|作者单位||1.Peking Univ, Sch Publ Hlth, Dept Social Med & Hlth Educ, Beijing 100871, Peoples R China|
2.Soochow Univ, Sch Radiat Med & Publ Hlth, Suzhou, Peoples R China
|Xu, Jia-Ying,Qin, Li-Qiang,Wang, Pei-Yu,et al. Effect of milk tripeptides on blood pressure: A meta-analysis of randomized controlled trials[J]. NUTRITION,2008,24(10):933-940.|
|APA||Xu, Jia-Ying,Qin, Li-Qiang,Wang, Pei-Yu,Li, Wei,&Chang, Chun.(2008).Effect of milk tripeptides on blood pressure: A meta-analysis of randomized controlled trials.NUTRITION,24(10),933-940.|
|MLA||Xu, Jia-Ying,et al."Effect of milk tripeptides on blood pressure: A meta-analysis of randomized controlled trials".NUTRITION 24.10(2008):933-940.|