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学科主题: 临床医学
题名:
Candida parapsilosis Sensu Stricto and the Closely Related Species Candida orthopsilosis and Candida metapsilosis in Vulvovaginal Candidiasis
作者: Zhu, Yuxia1; Shan, Yingying1; Fan, Shangrong1,2; Li, Jianling1; Liu, Xiaoping3
关键词: Vulvovaginal candidiasis ; Candida parapsilosis ; Antifungal susceptibility
刊名: MYCOPATHOLOGIA
发表日期: 2015-02-01
DOI: 10.1007/s11046-014-9821-x
卷: 179, 期:1-2, 页:111-118
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Mycology
研究领域[WOS]: Mycology
关键词[WOS]: ANTIFUNGAL SUSCEPTIBILITY ; SURVEILLANCE ; EPIDEMIOLOGY ; FLUCONAZOLE ; PREVALENCE ; POPULATION ; COMPLEX
英文摘要:

This study aimed to determine the clinical characteristics and in vitro susceptibilities of Candida parapsilosis sensu stricto, Candida orthopsilosis and Candida metapsilosis isolates from patients with vulvovaginal candidiasis (VVC). We analysed 63 vaginal C. parapsilosis specimens. After the molecular analyses, the isolates were characterised as C. parapsilosis sensu stricto (77.8 %), C. orthopsilosis (7.9 %) and C. metapsilosis (14.3 %). The signs and symptoms of VVC caused by C. parapsilosis sensu lato, including itching, erythema and abnormal discharge, were milder than those caused by C. albicans. None of the C. parapsilosis sensu lato isolates were resistant to fluconazole, miconazole or itraconazole. The resistance rates of C. albicans to fluconazole, itraconazole, miconazole and clotrimazole were 2.3, 1.5, 3.1 and 0.8 %, respectively. Both C. parapsilosis sensu lato and C. albicans were susceptible to nystatin. The mycological eradication rate at follow-up days 7-14 and 30-35 were 77.8 % (49/63) and 76.2 % (48/63), respectively, when treated with various antifungal agents and regimens. We conclude that C. parapsilosis sensu stricto and the closely related species C. orthopsilosis and C. metapsilosis were present in the vaginal samples of VVC patients. The symptoms and signs of VVC caused by C. parapsilosis are milder than those caused by C. albicans. The antifungal susceptibility and therapeutic efficacy in patients colonised by C. parapsilosis sensu lato were similar to those observed in C. albicans-colonised patients.

语种: 英语
所属项目编号: 200702108 ; 200703031 ; 20120320020
项目资助者: Shenzhen Science and Technology
WOS记录号: WOS:000349528700013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61298
Appears in Collections:北京大学深圳医院_期刊论文

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作者单位: 1.Peking Univ, Shenzhen Hosp, Dept Obstet & Gynaecol, Shenzhen 518036, Peoples R China
2.Shenzhen Key Lab Gynaecol Diagnost Technol Res, Shenzhen 518036, Peoples R China
3.Peking Univ, Shenzhen Hosp, Dept Lab Sci, Shenzhen, Peoples R China

Recommended Citation:
Zhu, Yuxia,Shan, Yingying,Fan, Shangrong,et al. Candida parapsilosis Sensu Stricto and the Closely Related Species Candida orthopsilosis and Candida metapsilosis in Vulvovaginal Candidiasis[J]. MYCOPATHOLOGIA,2015,179(1-2):111-118.
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