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Candida parapsilosis Sensu Stricto and the Closely Related Species Candida orthopsilosis and Candida metapsilosis in Vulvovaginal Candidiasis
Zhu, Yuxia1; Shan, Yingying1; Fan, Shangrong1,2; Li, Jianling1; Liu, Xiaoping3
关键词Vulvovaginal candidiasis Candida parapsilosis Antifungal susceptibility
刊名MYCOPATHOLOGIA
2015-02-01
DOI10.1007/s11046-014-9821-x
179期:1-2页:111-118
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Mycology
研究领域[WOS]Mycology
关键词[WOS]ANTIFUNGAL SUSCEPTIBILITY ; SURVEILLANCE ; EPIDEMIOLOGY ; FLUCONAZOLE ; PREVALENCE ; POPULATION ; COMPLEX
英文摘要

This study aimed to determine the clinical characteristics and in vitro susceptibilities of Candida parapsilosis sensu stricto, Candida orthopsilosis and Candida metapsilosis isolates from patients with vulvovaginal candidiasis (VVC). We analysed 63 vaginal C. parapsilosis specimens. After the molecular analyses, the isolates were characterised as C. parapsilosis sensu stricto (77.8 %), C. orthopsilosis (7.9 %) and C. metapsilosis (14.3 %). The signs and symptoms of VVC caused by C. parapsilosis sensu lato, including itching, erythema and abnormal discharge, were milder than those caused by C. albicans. None of the C. parapsilosis sensu lato isolates were resistant to fluconazole, miconazole or itraconazole. The resistance rates of C. albicans to fluconazole, itraconazole, miconazole and clotrimazole were 2.3, 1.5, 3.1 and 0.8 %, respectively. Both C. parapsilosis sensu lato and C. albicans were susceptible to nystatin. The mycological eradication rate at follow-up days 7-14 and 30-35 were 77.8 % (49/63) and 76.2 % (48/63), respectively, when treated with various antifungal agents and regimens. We conclude that C. parapsilosis sensu stricto and the closely related species C. orthopsilosis and C. metapsilosis were present in the vaginal samples of VVC patients. The symptoms and signs of VVC caused by C. parapsilosis are milder than those caused by C. albicans. The antifungal susceptibility and therapeutic efficacy in patients colonised by C. parapsilosis sensu lato were similar to those observed in C. albicans-colonised patients.

语种英语
WOS记录号WOS:000349528700013
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61298
专题北京大学深圳医院
作者单位1.Peking Univ, Shenzhen Hosp, Dept Obstet & Gynaecol, Shenzhen 518036, Peoples R China
2.Shenzhen Key Lab Gynaecol Diagnost Technol Res, Shenzhen 518036, Peoples R China
3.Peking Univ, Shenzhen Hosp, Dept Lab Sci, Shenzhen, Peoples R China
推荐引用方式
GB/T 7714
Zhu, Yuxia,Shan, Yingying,Fan, Shangrong,et al. Candida parapsilosis Sensu Stricto and the Closely Related Species Candida orthopsilosis and Candida metapsilosis in Vulvovaginal Candidiasis[J]. MYCOPATHOLOGIA,2015,179(1-2):111-118.
APA Zhu, Yuxia,Shan, Yingying,Fan, Shangrong,Li, Jianling,&Liu, Xiaoping.(2015).Candida parapsilosis Sensu Stricto and the Closely Related Species Candida orthopsilosis and Candida metapsilosis in Vulvovaginal Candidiasis.MYCOPATHOLOGIA,179(1-2),111-118.
MLA Zhu, Yuxia,et al."Candida parapsilosis Sensu Stricto and the Closely Related Species Candida orthopsilosis and Candida metapsilosis in Vulvovaginal Candidiasis".MYCOPATHOLOGIA 179.1-2(2015):111-118.
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