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Copper-Catalyzed Aerobic Oxidative Cross-Dehydrogenative Coupling of Amine and alpha-Carbonyl Aldehyde: A Practical and Efficient Approach to alpha-Ketoamides with Wide Substrate Scope
Zhang, Chun2; Zong, Xiaolin2; Zhang, Liangren2; Jiao, Ning1
刊名ORGANIC LETTERS
2012-07-06
DOI10.1021/ol301130u
14期:13页:3280-3283
收录类别SCI ; IC ; CCR
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Organic
研究领域[WOS]Chemistry
关键词[WOS]O-O BOND ; MOLECULAR-OXYGEN ; OXIDASE CATALYSIS ; ROOM-TEMPERATURE ; DIRECT ACCESS ; KETO-AMIDES ; PALLADIUM ; AMIDATION ; COMPLEXES ; DIOXYGEN
英文摘要

A copper-catalyzed aerobic oxidative cross-dehydrogenative coupling (CDC) of amine with alpha-carbonyl aldehyde has been developed. Many types of amines are tolerant in this transformation leading to various alpha-ketoamides compounds. Wide substrate scope, CDC strategy and using air as oxidant make this transformation highly efficient and practical. Molecular oxygen acts not only as the oxidant, but also as an initiator to trigger this catalytic process. Furthermore, mechanism studies show that carbonyl group of a-carbonyl aldehyde plays a role as the directing group to facilitate this chemical process.

语种英语
WOS记录号WOS:000306050300012
项目编号2009CB825300 ; 20872003
资助机构National Basic Research Program of China (973 Program) ; National Science Foundation of China ; State Key Laboratory of Drug Research
引用统计
被引频次:128[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61299
专题北京大学药学院
北京大学药学院_药物化学系
作者单位1.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
2.Peking Univ, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Chun,Zong, Xiaolin,Zhang, Liangren,et al. Copper-Catalyzed Aerobic Oxidative Cross-Dehydrogenative Coupling of Amine and alpha-Carbonyl Aldehyde: A Practical and Efficient Approach to alpha-Ketoamides with Wide Substrate Scope[J]. ORGANIC LETTERS,2012,14(13):3280-3283.
APA Zhang, Chun,Zong, Xiaolin,Zhang, Liangren,&Jiao, Ning.(2012).Copper-Catalyzed Aerobic Oxidative Cross-Dehydrogenative Coupling of Amine and alpha-Carbonyl Aldehyde: A Practical and Efficient Approach to alpha-Ketoamides with Wide Substrate Scope.ORGANIC LETTERS,14(13),3280-3283.
MLA Zhang, Chun,et al."Copper-Catalyzed Aerobic Oxidative Cross-Dehydrogenative Coupling of Amine and alpha-Carbonyl Aldehyde: A Practical and Efficient Approach to alpha-Ketoamides with Wide Substrate Scope".ORGANIC LETTERS 14.13(2012):3280-3283.
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