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学科主题: 药学
题名:
Copper-Catalyzed Aerobic Oxidative Cross-Dehydrogenative Coupling of Amine and alpha-Carbonyl Aldehyde: A Practical and Efficient Approach to alpha-Ketoamides with Wide Substrate Scope
作者: Zhang, Chun2; Zong, Xiaolin2; Zhang, Liangren2; Jiao, Ning1
刊名: ORGANIC LETTERS
发表日期: 2012-07-06
DOI: 10.1021/ol301130u
卷: 14, 期:13, 页:3280-3283
收录类别: SCI ; IC ; CCR
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Organic
研究领域[WOS]: Chemistry
关键词[WOS]: O-O BOND ; MOLECULAR-OXYGEN ; OXIDASE CATALYSIS ; ROOM-TEMPERATURE ; DIRECT ACCESS ; KETO-AMIDES ; PALLADIUM ; AMIDATION ; COMPLEXES ; DIOXYGEN
英文摘要:

A copper-catalyzed aerobic oxidative cross-dehydrogenative coupling (CDC) of amine with alpha-carbonyl aldehyde has been developed. Many types of amines are tolerant in this transformation leading to various alpha-ketoamides compounds. Wide substrate scope, CDC strategy and using air as oxidant make this transformation highly efficient and practical. Molecular oxygen acts not only as the oxidant, but also as an initiator to trigger this catalytic process. Furthermore, mechanism studies show that carbonyl group of a-carbonyl aldehyde plays a role as the directing group to facilitate this chemical process.

语种: 英语
所属项目编号: 2009CB825300 ; 20872003
项目资助者: National Basic Research Program of China (973 Program) ; National Science Foundation of China ; State Key Laboratory of Drug Research
WOS记录号: WOS:000306050300012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61299
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
2.Peking Univ, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100191, Peoples R China

Recommended Citation:
Zhang, Chun,Zong, Xiaolin,Zhang, Liangren,et al. Copper-Catalyzed Aerobic Oxidative Cross-Dehydrogenative Coupling of Amine and alpha-Carbonyl Aldehyde: A Practical and Efficient Approach to alpha-Ketoamides with Wide Substrate Scope[J]. ORGANIC LETTERS,2012,14(13):3280-3283.
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