IR@PKUHSC  > 北京大学药学院
学科主题药学
Copper-Catalyzed Aerobic Oxidative Cross-Dehydrogenative Coupling of Amine and alpha-Carbonyl Aldehyde: A Practical and Efficient Approach to alpha-Ketoamides with Wide Substrate Scope
Zhang, Chun2; Zong, Xiaolin2; Zhang, Liangren2; Jiao, Ning1
刊名ORGANIC LETTERS
2012-07-06
DOI10.1021/ol301130u
14期:13页:3280-3283
收录类别SCI ; IC ; CCR
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Organic
资助者National Basic Research Program of China (973 Program) ; National Science Foundation of China ; State Key Laboratory of Drug Research ; National Basic Research Program of China (973 Program) ; National Science Foundation of China ; State Key Laboratory of Drug Research
研究领域[WOS]Chemistry
关键词[WOS]O-O BOND ; MOLECULAR-OXYGEN ; OXIDASE CATALYSIS ; ROOM-TEMPERATURE ; DIRECT ACCESS ; KETO-AMIDES ; PALLADIUM ; AMIDATION ; COMPLEXES ; DIOXYGEN
英文摘要

A copper-catalyzed aerobic oxidative cross-dehydrogenative coupling (CDC) of amine with alpha-carbonyl aldehyde has been developed. Many types of amines are tolerant in this transformation leading to various alpha-ketoamides compounds. Wide substrate scope, CDC strategy and using air as oxidant make this transformation highly efficient and practical. Molecular oxygen acts not only as the oxidant, but also as an initiator to trigger this catalytic process. Furthermore, mechanism studies show that carbonyl group of a-carbonyl aldehyde plays a role as the directing group to facilitate this chemical process.

语种英语
所属项目编号2009CB825300 ; 20872003
资助者National Basic Research Program of China (973 Program) ; National Science Foundation of China ; State Key Laboratory of Drug Research ; National Basic Research Program of China (973 Program) ; National Science Foundation of China ; State Key Laboratory of Drug Research
WOS记录号WOS:000306050300012
Citation statistics
Cited Times:122[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61299
Collection北京大学药学院
作者单位1.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
2.Peking Univ, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Chun,Zong, Xiaolin,Zhang, Liangren,et al. Copper-Catalyzed Aerobic Oxidative Cross-Dehydrogenative Coupling of Amine and alpha-Carbonyl Aldehyde: A Practical and Efficient Approach to alpha-Ketoamides with Wide Substrate Scope[J]. ORGANIC LETTERS,2012,14(13):3280-3283.
APA Zhang, Chun,Zong, Xiaolin,Zhang, Liangren,&Jiao, Ning.(2012).Copper-Catalyzed Aerobic Oxidative Cross-Dehydrogenative Coupling of Amine and alpha-Carbonyl Aldehyde: A Practical and Efficient Approach to alpha-Ketoamides with Wide Substrate Scope.ORGANIC LETTERS,14(13),3280-3283.
MLA Zhang, Chun,et al."Copper-Catalyzed Aerobic Oxidative Cross-Dehydrogenative Coupling of Amine and alpha-Carbonyl Aldehyde: A Practical and Efficient Approach to alpha-Ketoamides with Wide Substrate Scope".ORGANIC LETTERS 14.13(2012):3280-3283.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
谷歌学术
谷歌学术Similar articles in
[Zhang, Chun]'s Articles
[Zong, Xiaolin]'s Articles
[Zhang, Liangren]'s Articles
百度学术
百度学术Similar articles in
[Zhang, Chun]'s Articles
[Zong, Xiaolin]'s Articles
[Zhang, Liangren]'s Articles
必应学术
必应学术Similar articles in
[Zhang, Chun]'s Articles
[Zong, Xiaolin]'s Articles
[Zhang, Liangren]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.