北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第三临床医学院  > 心血管内科  > 期刊论文
学科主题: 临床医学
题名:
Mitofusin 2 Inhibits Angiotensin II-Induced Myocardial Hypertrophy
作者: Yu, Haiyi1,2; Guo, Yanhong1,2; Mi, Lin1,2; Wang, Xueying1,2; Li, Lei1,2; Gao, Wei1,2
关键词: cardiac remodeling ; myocyte hypertrophy ; mitofusin 2
刊名: JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS
发表日期: 2011-06-01
DOI: 10.1177/1074248410385683
卷: 16, 期:2, 页:205-211
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cardiac & Cardiovascular Systems ; Pharmacology & Pharmacy
研究领域[WOS]: Cardiovascular System & Cardiology ; Pharmacology & Pharmacy
关键词[WOS]: RAT CARDIAC FIBROBLASTS ; REGULATED KINASE PATHWAY ; MUSCLE-CELL APOPTOSIS ; IN-VITRO ; GENE ; PROLIFERATION ; EXPRESSION ; VIVO ; CARDIOMYOCYTES ; ENDOTHELIN-1
英文摘要:

Background and Objectives: Myocardial hypertrophy is a common clinical finding leading to heart failure and sudden death. Mitofusin 2 (Mfn2), a hyperplasia suppressor protein, is downregulated in hypertrophic heart. This study examined the role of Mfn2 in myocardial hypertrophy and its potential signal pathway. Methods and Results: In in vitro studies, neonatal cardiac myocytes were isolated and cultured. Incubation of cultured cardiomycytes with angiotensin II (Ang II) inhibited gene expression of Mfn2; induced cell hypertrophy and protein synthesis; and activated protein kinase Akt. Pretreatment of cells with AdMfn2-a replication-deficient adenoviral vector encoding rat Mfn2 gene-upregulated Mfn2 expression and subsequently attenuated Ang II-induced cell hypertrophy; protein synthesis; and Akt activation. In in vivo studies, direct gene delivery of AdMfn2 into myocardium decreased the infusion of Ang II-induced atrial natriuretic factor (ANF, a hypertrophic marker) expression and cardiomyocyte cross-sectional area. Consistently, upregulation of Mfn2 in myocardium decreased the thicknesses of anterior and posterior walls of left ventricle (LV) and the ratio of LV mass/body weight in Ang II-treated rats. Of note, AdGFP (control for AdMfn2) did not affect the effects of Ang II in vitro or in vivo. Conclusions: Upregulation of Mfn2 inhibits Ang II-induced myocardial hypertrophy. In this process, inhibition of Akt activation seems to play a significant role. These findings indicate Mfn2 is a critical protein in modulating myocyte hypertrophy.

语种: 英语
所属项目编号: 2008AA02Z441 ; 20060001143
项目资助者: China national high-tech research and development plan "863" project ; Ministry of Education of China
WOS记录号: WOS:000290562100012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61304
Appears in Collections:北京大学第三临床医学院_心血管内科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing, Peoples R China
2.Peking Univ, Hosp 3, Dept Cardiol, Beijing 100191, Peoples R China

Recommended Citation:
Yu, Haiyi,Guo, Yanhong,Mi, Lin,et al. Mitofusin 2 Inhibits Angiotensin II-Induced Myocardial Hypertrophy[J]. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS,2011,16(2):205-211.
[Mi, Lin]'s Articles
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Yu, Haiyi]'s Articles
[Guo, Yanhong]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Yu, Haiyi]‘s Articles
[Guo, Yanhong]‘s Articles
[Mi, Lin]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace