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学科主题临床医学
Mitofusin 2 Inhibits Angiotensin II-Induced Myocardial Hypertrophy
Yu, Haiyi1,2; Guo, Yanhong1,2; Mi, Lin1,2; Wang, Xueying1,2; Li, Lei1,2; Gao, Wei1,2
关键词cardiac remodeling myocyte hypertrophy mitofusin 2
刊名JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS
2011-06-01
DOI10.1177/1074248410385683
16期:2页:205-211
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cardiac & Cardiovascular Systems ; Pharmacology & Pharmacy
研究领域[WOS]Cardiovascular System & Cardiology ; Pharmacology & Pharmacy
关键词[WOS]RAT CARDIAC FIBROBLASTS ; REGULATED KINASE PATHWAY ; MUSCLE-CELL APOPTOSIS ; IN-VITRO ; GENE ; PROLIFERATION ; EXPRESSION ; VIVO ; CARDIOMYOCYTES ; ENDOTHELIN-1
英文摘要

Background and Objectives: Myocardial hypertrophy is a common clinical finding leading to heart failure and sudden death. Mitofusin 2 (Mfn2), a hyperplasia suppressor protein, is downregulated in hypertrophic heart. This study examined the role of Mfn2 in myocardial hypertrophy and its potential signal pathway. Methods and Results: In in vitro studies, neonatal cardiac myocytes were isolated and cultured. Incubation of cultured cardiomycytes with angiotensin II (Ang II) inhibited gene expression of Mfn2; induced cell hypertrophy and protein synthesis; and activated protein kinase Akt. Pretreatment of cells with AdMfn2-a replication-deficient adenoviral vector encoding rat Mfn2 gene-upregulated Mfn2 expression and subsequently attenuated Ang II-induced cell hypertrophy; protein synthesis; and Akt activation. In in vivo studies, direct gene delivery of AdMfn2 into myocardium decreased the infusion of Ang II-induced atrial natriuretic factor (ANF, a hypertrophic marker) expression and cardiomyocyte cross-sectional area. Consistently, upregulation of Mfn2 in myocardium decreased the thicknesses of anterior and posterior walls of left ventricle (LV) and the ratio of LV mass/body weight in Ang II-treated rats. Of note, AdGFP (control for AdMfn2) did not affect the effects of Ang II in vitro or in vivo. Conclusions: Upregulation of Mfn2 inhibits Ang II-induced myocardial hypertrophy. In this process, inhibition of Akt activation seems to play a significant role. These findings indicate Mfn2 is a critical protein in modulating myocyte hypertrophy.

语种英语
WOS记录号WOS:000290562100012
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被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61304
专题北京大学第三临床医学院_心血管内科
作者单位1.Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing, Peoples R China
2.Peking Univ, Hosp 3, Dept Cardiol, Beijing 100191, Peoples R China
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GB/T 7714
Yu, Haiyi,Guo, Yanhong,Mi, Lin,et al. Mitofusin 2 Inhibits Angiotensin II-Induced Myocardial Hypertrophy[J]. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS,2011,16(2):205-211.
APA Yu, Haiyi,Guo, Yanhong,Mi, Lin,Wang, Xueying,Li, Lei,&Gao, Wei.(2011).Mitofusin 2 Inhibits Angiotensin II-Induced Myocardial Hypertrophy.JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS,16(2),205-211.
MLA Yu, Haiyi,et al."Mitofusin 2 Inhibits Angiotensin II-Induced Myocardial Hypertrophy".JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS 16.2(2011):205-211.
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