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学科主题: 基础医学
题名:
Transmembrane Protein 208:A Novel ER-Localized Protein That Regulates Autophagy and ER Stress
作者: Zhao, Yuanbo1,2; Hu, Jia1,2; Miao, Guangyan1,2; Qu, Liujing1,2; Wang, Zhenda1,2; Li, Ge1,2; Lv, Ping1,2; Ma, Dalong1,2; Chen, Yingyu1,2
刊名: PLOS ONE
发表日期: 2013-05-14
DOI: 10.1371/journal.pone.0064228
卷: 8, 期:5
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: ENDOPLASMIC-RETICULUM ; SELF-DIGESTION ; LC3 ; IDENTIFICATION ; ATF4
英文摘要:

Autophagy and endoplasmic reticulum (ER) stress are both tightly regulated cellular processes that play central roles in various physiological and pathological conditions. Recent reports have indicated that ER stress is a potent inducer of autophagy. However, little is known about the underlying molecular link between the two processes. Here we report a novel human protein, transmembrane protein 208 (TMEM208) that can regulate both autophagy and ER stress. When overexpressed, TMEM208 impaired autophagy as characterized by the decrease of the accumulation of LC3-II, decreased degradation of autophagic substrates, and reduced expression of critical effectors and vital molecules of the ER stress and autophagy processes. In contrast, knockdown of the TMEM208 gene promoted autophagy, as demonstrated by the increase of LC3-II, increased degradation of autophagic substrates, and enhanced expression levels for genes key in the ER stress and autophagic processes. Taken together, our results reveal that this novel ER-located protein regulates both ER stress and autophagy, and represents a possible link between the two different cellular processes.

语种: 英语
所属项目编号: 2011CB910103
项目资助者: National Key Basic Research Program of China (973 Program)
WOS记录号: WOS:000319107400107
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61305
Appears in Collections:基础医学院_免疫学系_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Minist Hlth, Key Lab Med Immunol, Beijing 100871, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Ctr Human Dis Genom, Beijing 100871, Peoples R China

Recommended Citation:
Zhao, Yuanbo,Hu, Jia,Miao, Guangyan,et al. Transmembrane Protein 208:A Novel ER-Localized Protein That Regulates Autophagy and ER Stress[J]. PLOS ONE,2013,8(5).
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