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学科主题基础医学
Transmembrane Protein 208:A Novel ER-Localized Protein That Regulates Autophagy and ER Stress
Zhao, Yuanbo1,2; Hu, Jia1,2; Miao, Guangyan1,2; Qu, Liujing1,2; Wang, Zhenda1,2; Li, Ge1,2; Lv, Ping1,2; Ma, Dalong1,2; Chen, Yingyu1,2
刊名PLOS ONE
2013-05-14
DOI10.1371/journal.pone.0064228
8期:5
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]ENDOPLASMIC-RETICULUM ; SELF-DIGESTION ; LC3 ; IDENTIFICATION ; ATF4
英文摘要

Autophagy and endoplasmic reticulum (ER) stress are both tightly regulated cellular processes that play central roles in various physiological and pathological conditions. Recent reports have indicated that ER stress is a potent inducer of autophagy. However, little is known about the underlying molecular link between the two processes. Here we report a novel human protein, transmembrane protein 208 (TMEM208) that can regulate both autophagy and ER stress. When overexpressed, TMEM208 impaired autophagy as characterized by the decrease of the accumulation of LC3-II, decreased degradation of autophagic substrates, and reduced expression of critical effectors and vital molecules of the ER stress and autophagy processes. In contrast, knockdown of the TMEM208 gene promoted autophagy, as demonstrated by the increase of LC3-II, increased degradation of autophagic substrates, and enhanced expression levels for genes key in the ER stress and autophagic processes. Taken together, our results reveal that this novel ER-located protein regulates both ER stress and autophagy, and represents a possible link between the two different cellular processes.

语种英语
WOS记录号WOS:000319107400107
项目编号2011CB910103
资助机构National Key Basic Research Program of China (973 Program)
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61305
专题北京大学基础医学院_免疫学系
北京大学基础医学院
北京大学口腔医学院_儿童口腔科
作者单位1.Peking Univ, Hlth Sci Ctr, Minist Hlth, Key Lab Med Immunol, Beijing 100871, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Ctr Human Dis Genom, Beijing 100871, Peoples R China
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GB/T 7714
Zhao, Yuanbo,Hu, Jia,Miao, Guangyan,et al. Transmembrane Protein 208:A Novel ER-Localized Protein That Regulates Autophagy and ER Stress[J]. PLOS ONE,2013,8(5).
APA Zhao, Yuanbo.,Hu, Jia.,Miao, Guangyan.,Qu, Liujing.,Wang, Zhenda.,...&Chen, Yingyu.(2013).Transmembrane Protein 208:A Novel ER-Localized Protein That Regulates Autophagy and ER Stress.PLOS ONE,8(5).
MLA Zhao, Yuanbo,et al."Transmembrane Protein 208:A Novel ER-Localized Protein That Regulates Autophagy and ER Stress".PLOS ONE 8.5(2013).
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