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学科主题: 临床医学
题名:
Endometriosis Is Associated with Progesterone Resistance in the Baboon (Papio anubis) Oviduct: Evidence Based on the Localization of Oviductal Glycoprotein 1 (OVGP1)
作者: Wang, Chaohua2; Mavrogianis, Patricia A.1; Fazleabas, Asgerally T.1
关键词: endometriosis ; estradiol receptor ; OVGP1 ; oviduct ; progesterone receptor ; progesterone resistance ; steroid receptors
刊名: BIOLOGY OF REPRODUCTION
发表日期: 2009-02-01
DOI: 10.1095/biolreprod.108.072496
卷: 80, 期:2, 页:272-278
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Reproductive Biology
研究领域[WOS]: Reproductive Biology
关键词[WOS]: MENSTRUAL-CYCLE ; IMMUNOCYTOCHEMICAL LOCALIZATION ; IMMUNOLOGICAL CHARACTERIZATION ; CHORIONIC-GONADOTROPIN ; UTERINE RECEPTIVITY ; EXPRESSION ; RECEPTOR ; MODEL ; ESTROGEN ; GENE
英文摘要:

Endometriosis has been associated with a reduced response to progesterone in both the eutopic and ectopic endometrium. In this study we evaluated OVGP1 and steroid receptor expression in oviducts of baboons with endometriosis during the midsecretory phase and determined whether progesterone resistance associated with endometriosis also occurs in the oviduct. Oviducts obtained during the window of uterine receptivity (Day 10 postovulation [PO]) from animals with induced and spontaneous disease were compared to control animals during the proliferative stage and in the implantation window as well as animals treated with the progesterone receptor (PGR) antagonist ZK 137.299 ( ZK). OVGP1 was significantly higher in animals with endometriosis compared with Day 10 PO controls and was similar to that seen in the late proliferative phase and in ZK-treated animals. Baboons with spontaneous endometriosis also showed a similar persistence of OVGP1, which was correlated with the maintenance of estrogen receptor 1 (ESR1) in the epithelial cells of animals with endometriosis. However, epithelial cell height and the percentage of ciliation were not affected by endometriosis. These data imply that the normal antagonism of progesterone on ESR and OVGP1, which results in their downregulation during the window of implantation, is absent in animals with endometriosis. This was confirmed further when the action of PGR was antagonized in animals without disease, which also resulted in the persistence of ESR1 and OVGP1. These studies suggest that an aberrant oviductal environment may be an additive factor that contributes to endometriosis-associated infertility.

语种: 英语
所属项目编号: U54 HD 40093
项目资助者: Eunice Kennedy Shriver National Institute of Child Health ; Human Development/National Institutes of Health
WOS记录号: WOS:000262603600009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61306
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Univ Illinois, Dept Obstet & Gynecol, Chicago, IL 60612 USA
2.Beijing Univ, Peoples Hosp, Dept Obstet & Gynecol, Beijing 10004, Peoples R China

Recommended Citation:
Wang, Chaohua,Mavrogianis, Patricia A.,Fazleabas, Asgerally T.. Endometriosis Is Associated with Progesterone Resistance in the Baboon (Papio anubis) Oviduct: Evidence Based on the Localization of Oviductal Glycoprotein 1 (OVGP1)[J]. BIOLOGY OF REPRODUCTION,2009,80(2):272-278.
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