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Endometriosis Is Associated with Progesterone Resistance in the Baboon (Papio anubis) Oviduct: Evidence Based on the Localization of Oviductal Glycoprotein 1 (OVGP1)
Wang, Chaohua2; Mavrogianis, Patricia A.1; Fazleabas, Asgerally T.1
关键词endometriosis estradiol receptor OVGP1 oviduct progesterone receptor progesterone resistance steroid receptors
刊名BIOLOGY OF REPRODUCTION
2009-02-01
DOI10.1095/biolreprod.108.072496
80期:2页:272-278
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Reproductive Biology
研究领域[WOS]Reproductive Biology
关键词[WOS]MENSTRUAL-CYCLE ; IMMUNOCYTOCHEMICAL LOCALIZATION ; IMMUNOLOGICAL CHARACTERIZATION ; CHORIONIC-GONADOTROPIN ; UTERINE RECEPTIVITY ; EXPRESSION ; RECEPTOR ; MODEL ; ESTROGEN ; GENE
英文摘要

Endometriosis has been associated with a reduced response to progesterone in both the eutopic and ectopic endometrium. In this study we evaluated OVGP1 and steroid receptor expression in oviducts of baboons with endometriosis during the midsecretory phase and determined whether progesterone resistance associated with endometriosis also occurs in the oviduct. Oviducts obtained during the window of uterine receptivity (Day 10 postovulation [PO]) from animals with induced and spontaneous disease were compared to control animals during the proliferative stage and in the implantation window as well as animals treated with the progesterone receptor (PGR) antagonist ZK 137.299 ( ZK). OVGP1 was significantly higher in animals with endometriosis compared with Day 10 PO controls and was similar to that seen in the late proliferative phase and in ZK-treated animals. Baboons with spontaneous endometriosis also showed a similar persistence of OVGP1, which was correlated with the maintenance of estrogen receptor 1 (ESR1) in the epithelial cells of animals with endometriosis. However, epithelial cell height and the percentage of ciliation were not affected by endometriosis. These data imply that the normal antagonism of progesterone on ESR and OVGP1, which results in their downregulation during the window of implantation, is absent in animals with endometriosis. This was confirmed further when the action of PGR was antagonized in animals without disease, which also resulted in the persistence of ESR1 and OVGP1. These studies suggest that an aberrant oviductal environment may be an additive factor that contributes to endometriosis-associated infertility.

语种英语
WOS记录号WOS:000262603600009
项目编号U54 HD 40093
资助机构Eunice Kennedy Shriver National Institute of Child Health ; Human Development/National Institutes of Health
引用统计
被引频次:21[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61306
专题北京大学第二临床医学院
作者单位1.Univ Illinois, Dept Obstet & Gynecol, Chicago, IL 60612 USA
2.Beijing Univ, Peoples Hosp, Dept Obstet & Gynecol, Beijing 10004, Peoples R China
推荐引用方式
GB/T 7714
Wang, Chaohua,Mavrogianis, Patricia A.,Fazleabas, Asgerally T.. Endometriosis Is Associated with Progesterone Resistance in the Baboon (Papio anubis) Oviduct: Evidence Based on the Localization of Oviductal Glycoprotein 1 (OVGP1)[J]. BIOLOGY OF REPRODUCTION,2009,80(2):272-278.
APA Wang, Chaohua,Mavrogianis, Patricia A.,&Fazleabas, Asgerally T..(2009).Endometriosis Is Associated with Progesterone Resistance in the Baboon (Papio anubis) Oviduct: Evidence Based on the Localization of Oviductal Glycoprotein 1 (OVGP1).BIOLOGY OF REPRODUCTION,80(2),272-278.
MLA Wang, Chaohua,et al."Endometriosis Is Associated with Progesterone Resistance in the Baboon (Papio anubis) Oviduct: Evidence Based on the Localization of Oviductal Glycoprotein 1 (OVGP1)".BIOLOGY OF REPRODUCTION 80.2(2009):272-278.
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