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学科主题: 临床医学
题名:
Suppression of androgen receptor transactivation by Pyk2 via interaction and phosphorylation of the ARA55 coregulator
作者: Wang, X; Yang, Y; Guo, XJ; Sampson, ER; Hsu, CL; Tsai, MY; Yeh, SY; Wu, G; Guo, YL; Chang, CS
刊名: JOURNAL OF BIOLOGICAL CHEMISTRY
发表日期: 2002-05-03
DOI: 10.1074/jbc.M111218200
卷: 277, 期:18, 页:15426-15431
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology
研究领域[WOS]: Biochemistry & Molecular Biology
关键词[WOS]: PROSTATE-CANCER CELLS ; TYROSINE KINASE ; SIGNALING PATHWAY ; ESTROGEN-RECEPTOR ; GROWTH-FACTOR ; ACTIVATION ; PROTEIN ; IDENTIFICATION ; COACTIVATOR ; EXPRESSION
英文摘要:

The proline-rich tyrosine kinase 2 (Pyk2) was first identified as a key kinase linked to the MAP kinase and JNK signaling pathways that play important roles in cell growth and adhesion. The linkage between Pyk2 and the androgen receptor (AR), an important transcription factor in prostate cancer progression, however, remains unclear. Here we report that using the full-length androgen receptor-associated protein, ARA55, coregulator as bait, we were able to isolate an ARA55-interacting protein, Pyk2, and demonstrated that Pyk2 could repress AR transactivation via inactivation of ARA55. This inactivation may result from the direct phosphorylation of ARA55 by Pyk2 at tyrosine 43, impairing the coactivator activity of ARA55 and/or sequestering ARA55 to reduce its interaction with AR. Our finding that Pyk2 can indirectly modulate AR function via interaction and/or phosphorylation of ARA55 not only expands the role of Pyk2 in AR-mediated prostate cancer growth but also strengthens the role of ARA55 as an AR coregulator.

语种: 英语
WOS记录号: WOS:000175510400028
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61309
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: 1.Univ Rochester, Dept Urol, George Whipple Lab Canc Res, Rochester, NY 14642 USA
2.Univ Rochester, Ctr Canc, Rochester, NY 14642 USA
3.Peking Univ, Hosp 1, Beijing 100034, Peoples R China
4.Univ Rochester, Dept Pathol, George Whipple Lab Canc Res, Rochester, NY 14642 USA
5.Univ Rochester, Dept Radiat Oncol, George Whipple Lab Canc Res, Rochester, NY 14642 USA

Recommended Citation:
Wang, X,Yang, Y,Guo, XJ,et al. Suppression of androgen receptor transactivation by Pyk2 via interaction and phosphorylation of the ARA55 coregulator[J]. JOURNAL OF BIOLOGICAL CHEMISTRY,2002,277(18):15426-15431.
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