IR@PKUHSC  > 北京大学基础医学院  > 病原生物学系
学科主题基础医学
HBV/D1: a major HBV subgenotype circulating in Uyghur patients with chronic HBV infection in Xinjiang, China
Nie, Jingjing1,2; Li, Jie1,2; Sun, Kuixia1,2; Sun, Mishu1,2; Chen, Jie1,2; Ma, Junfeng1,2; Yan, Ling1,2; Zhuang, Hui1,2
刊名ARCHIVES OF VIROLOGY
2012-08-01
DOI10.1007/s00705-012-1325-8
157期:8页:1541-1549
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Virology
资助者Major Science and Technology Special Project of China Eleventh Five-year Plan ; Major Science and Technology Special Project of China Eleventh Five-year Plan
研究领域[WOS]Virology
关键词[WOS]HEPATITIS-B-VIRUS ; PHYLOGENETIC RELATEDNESS ; GENETIC DIVERSITY ; SURFACE-ANTIGEN ; GENOTYPE-D ; SEQUENCES ; TRANSMISSION ; PREGNANCY ; DELETION ; SUBTYPES
英文摘要

Each hepatitis B virus (HBV) genotype and subgenotype is associated with a particular geographic distribution, ethnicity, and anthropological history. The present study investigated the genomic characteristics of HBV from Uyghur patients with chronic HBV infection in Xinjiang, China. Among the 53 Uyghur patients enrolled, HBV/D was found to be the dominant strain, with 64.2 % (34/53), 60.4 % (32/53) with HBV/D1 and 3.8 % (2/53) with HBV/D3. In addition to these findings, 3.8 % HBV/B (2/53), 5.7 % HBV/C (3/53), 11.3 % C+D (6/53), 7.5 % B+D (4/53), 3.8 % B+C (2/53) and 3.8 % B+C+D (2/53) were also detected. The full-length genome of seven HBV/D1 isolates and 144 reference sequences retrieved from GenBank were compared and analyzed by biological information methods. These results demonstrate that the D1 isolates from Xinjiang and Central Asia show a close genetic proximity (0.013 +/- 0.0007). Furthermore, four unique amino acid substitutions (sp82(Asn), sp89(His), rt129(Leu), rt151(Leu)) representing background polymorphisms rather than drug resistance mutations or immune escape variants were found in the Uyghur patients of Xinjiang, but these were seldom found in HBV/D1 strains from other regions (0 %-14.3 %). This study indicates that in Xinjiang, unlike HBV-infected Han patients, HBV/D1 is the predominant strain among HBV-infected Uyghur people. Although genetic distance analysis suggests that the HBV/D1 isolates from Xinjiang are closely related to those from Central Asia, unique amino acid substitutions suggest independent evolution of HBV in the Uyghur patients of Xinjiang.

语种英语
所属项目编号2008ZX10002-001
资助者Major Science and Technology Special Project of China Eleventh Five-year Plan ; Major Science and Technology Special Project of China Eleventh Five-year Plan
WOS记录号WOS:000307253800012
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61310
Collection北京大学基础医学院_病原生物学系
作者单位1.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Microbiol, Beijing 100191, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Ctr Infect Dis, Beijing 100191, Peoples R China
Recommended Citation
GB/T 7714
Nie, Jingjing,Li, Jie,Sun, Kuixia,et al. HBV/D1: a major HBV subgenotype circulating in Uyghur patients with chronic HBV infection in Xinjiang, China[J]. ARCHIVES OF VIROLOGY,2012,157(8):1541-1549.
APA Nie, Jingjing.,Li, Jie.,Sun, Kuixia.,Sun, Mishu.,Chen, Jie.,...&Zhuang, Hui.(2012).HBV/D1: a major HBV subgenotype circulating in Uyghur patients with chronic HBV infection in Xinjiang, China.ARCHIVES OF VIROLOGY,157(8),1541-1549.
MLA Nie, Jingjing,et al."HBV/D1: a major HBV subgenotype circulating in Uyghur patients with chronic HBV infection in Xinjiang, China".ARCHIVES OF VIROLOGY 157.8(2012):1541-1549.
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