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学科主题: 基础医学
题名:
HBV/D1: a major HBV subgenotype circulating in Uyghur patients with chronic HBV infection in Xinjiang, China
作者: Nie, Jingjing1,2; Li, Jie1,2; Sun, Kuixia1,2; Sun, Mishu1,2; Chen, Jie1,2; Ma, Junfeng1,2; Yan, Ling1,2; Zhuang, Hui1,2
刊名: ARCHIVES OF VIROLOGY
发表日期: 2012-08-01
DOI: 10.1007/s00705-012-1325-8
卷: 157, 期:8, 页:1541-1549
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Virology
研究领域[WOS]: Virology
关键词[WOS]: HEPATITIS-B-VIRUS ; PHYLOGENETIC RELATEDNESS ; GENETIC DIVERSITY ; SURFACE-ANTIGEN ; GENOTYPE-D ; SEQUENCES ; TRANSMISSION ; PREGNANCY ; DELETION ; SUBTYPES
英文摘要:

Each hepatitis B virus (HBV) genotype and subgenotype is associated with a particular geographic distribution, ethnicity, and anthropological history. The present study investigated the genomic characteristics of HBV from Uyghur patients with chronic HBV infection in Xinjiang, China. Among the 53 Uyghur patients enrolled, HBV/D was found to be the dominant strain, with 64.2 % (34/53), 60.4 % (32/53) with HBV/D1 and 3.8 % (2/53) with HBV/D3. In addition to these findings, 3.8 % HBV/B (2/53), 5.7 % HBV/C (3/53), 11.3 % C+D (6/53), 7.5 % B+D (4/53), 3.8 % B+C (2/53) and 3.8 % B+C+D (2/53) were also detected. The full-length genome of seven HBV/D1 isolates and 144 reference sequences retrieved from GenBank were compared and analyzed by biological information methods. These results demonstrate that the D1 isolates from Xinjiang and Central Asia show a close genetic proximity (0.013 +/- 0.0007). Furthermore, four unique amino acid substitutions (sp82(Asn), sp89(His), rt129(Leu), rt151(Leu)) representing background polymorphisms rather than drug resistance mutations or immune escape variants were found in the Uyghur patients of Xinjiang, but these were seldom found in HBV/D1 strains from other regions (0 %-14.3 %). This study indicates that in Xinjiang, unlike HBV-infected Han patients, HBV/D1 is the predominant strain among HBV-infected Uyghur people. Although genetic distance analysis suggests that the HBV/D1 isolates from Xinjiang are closely related to those from Central Asia, unique amino acid substitutions suggest independent evolution of HBV in the Uyghur patients of Xinjiang.

语种: 英语
所属项目编号: 2008ZX10002-001
项目资助者: Major Science and Technology Special Project of China Eleventh Five-year Plan
WOS记录号: WOS:000307253800012
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61310
Appears in Collections:基础医学院_病原生物学系_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Microbiol, Beijing 100191, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Ctr Infect Dis, Beijing 100191, Peoples R China

Recommended Citation:
Nie, Jingjing,Li, Jie,Sun, Kuixia,et al. HBV/D1: a major HBV subgenotype circulating in Uyghur patients with chronic HBV infection in Xinjiang, China[J]. ARCHIVES OF VIROLOGY,2012,157(8):1541-1549.
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