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IR@PKUHSC  > 北京大学第三临床医学院  > 眼科  > 期刊论文
学科主题: 临床医学
题名:
Punctal plugs versus artificial tears for treating primary Sjogren′s syndrome with keratoconjunctivitis SICCA: a comparative observation of their effects on visual function
作者: Qiu, Weiqiang1,2; Liu, Ziyuan1,2; Ao, Mingxin1,2; Li, Xuemin1,2; Wang, Wei1,2
关键词: Sjogren&prime ; s syndrome ; Dry eye ; Punctal plugs ; Artificial tears ; Contrast sensitivity
刊名: RHEUMATOLOGY INTERNATIONAL
发表日期: 2013-10-01
DOI: 10.1007/s00296-013-2769-1
卷: 33, 期:10, 页:2543-2548
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Rheumatology
研究领域[WOS]: Rheumatology
关键词[WOS]: CORNEAL SURFACE REGULARITY ; CONTRAST SENSITIVITY ; OCULAR IRRITATION ; DRY EYES ; FILM
英文摘要:

To compare the effects of treatment with punctal plugs versus artificial tears on visual function for primary Sjogren′s syndrome with dry eye. Forty-two eyes of 42 patients with primary Sjogren′s syndrome were enrolled and were allocated randomly into artificial tears (AT) group and punctal plugs (PP) group. Ocular Surface Disease Index (OSDI) was used, and fluorescent staining for tear film break-up time (BUT), the Schirmer test I (STI) and contrast sensitivity was performed before treatment and was repeated 3 months after treatment. A follow-up of 3 months was achieved in 40 eyes of 40 patients, including 19 eyes in artificial tears group and 21 eyes in punctal plugs group. Statistically significant improvements were observed in the OSDI scores (AT: 52.6 +/- A 5.7, 15.9 +/- A 4.2; PP: 55.8 +/- A 4.9, 15.1 +/- A 4.2), corneal fluorescein staining scores (AT: 2.60 +/- A 1.76, 0.30 +/- A 0.57; PP: 1.91 +/- A 1.60, 0.09 +/- A 0.29), STI (AT: 3.85 +/- A 2.03, 8.95 +/- A 2.72; PP: 3.36 +/- A 1.62, 11.41 +/- A 2.65), and BUT (AT: 2.60 +/- A 1.39, 6.00 +/- A 1.81; PP: 2.27 +/- A 1.12, 7.82 +/- A 1.84) after treatment compared to those of pre-treatment. The values of STI (AT: 5.10 +/- A 1.80; PP: 8.05 +/- A 1.53) and BUT (AT: 3.40 +/- A 1.31; PP: 5.68 +/- A 1.13) in punctal plugs group were significantly more improved than those in the artificial tears group. The medium- and high-level frequencies contrast sensitivities were greatly improved in simulated daylight, night, and glare disability conditions after treatment with artificial tears and punctal plugs. However, the changes in contrast sensitivity did not significantly differ between groups. Both artificial tears and punctal plugs relieved dry eye symptoms, repaired corneal lesions, enhanced tear film stability, and improved contrast sensitivity. Punctal plugs could improve tear film stability and elongate the BUT better than artificial tears.

语种: 英语
所属项目编号: 79495-01 ; 79495-02
项目资助者: Peking University Third Hospital
WOS记录号: WOS:000324824500012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61311
Appears in Collections:北京大学第三临床医学院_眼科_期刊论文

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作者单位: 1.Minist Educ, Key Lab Vis Loss & Restorat, Beijing, Peoples R China
2.Peking Univ, Dept Ophthalmol, Hosp 3, Beijing 100191, Peoples R China

Recommended Citation:
Qiu, Weiqiang,Liu, Ziyuan,Ao, Mingxin,et al. Punctal plugs versus artificial tears for treating primary Sjogren′s syndrome with keratoconjunctivitis SICCA: a comparative observation of their effects on visual function[J]. RHEUMATOLOGY INTERNATIONAL,2013,33(10):2543-2548.
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