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学科主题临床医学
Propylthiouracil-induced antineutrophil cytoplasmic antibody-associated vasculitis
Chen, Min1; Gao, Ying2; Guo, Xiao-Hui2; Zhao, Ming-Hui1
刊名NATURE REVIEWS NEPHROLOGY
2012-08-01
DOI10.1038/nrneph.2012.108
8期:8页:476-483
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Urology & Nephrology
资助者Chinese 973 project ; National Natural Science Fund ; Chinese 973 project ; National Natural Science Fund
研究领域[WOS]Urology & Nephrology
关键词[WOS]ANCA-ASSOCIATED VASCULITIDES ; SENSORINEURAL HEARING-LOSS ; DRUG-INDUCED VASCULITIS ; RAT BONE-MARROW ; TERM-FOLLOW-UP ; GRAVES-DISEASE ; ANTITHYROID DRUGS ; ANTIMYELOPEROXIDASE ANTIBODIES ; MPO-ANCA ; CRESCENTIC GLOMERULONEPHRITIS
英文摘要

Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) refers to a group of potentially life-threatening autoimmune diseases. A recent development in this field is the recognition that certain drugs can induce AAV. Among these agents, the drug most often implicated in causing disease is the commonly used antithyroid agent propylthiouracil (PTU). This Review provides an update on PTU-induced AAV. Clinical characteristics of PTU-induced AAV are similar to that of primary AAV, but usually have a milder course and better prognosis, provided early cessation of the disease-causing drug. PTU-induced ANCAs usually react to several components of myeloid granules, which is helpful in differentiating PTU-induced AAV from primary AAV. Early cessation of PTU is crucial in the treatment of PTU-induced AAV. The duration of immunosuppressive therapy might be shorter than in primary AAV, depending on the severity of organ damage, and maintenance therapy is not always necessary.

语种英语
所属项目编号2012CB517702 ; 30972733 ; 81021004
资助者Chinese 973 project ; National Natural Science Fund ; Chinese 973 project ; National Natural Science Fund
WOS记录号WOS:000306828200009
Citation statistics
Cited Times:18[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61312
Collection北京大学第一临床医学院_肾脏内科
作者单位1.Peking Univ First Hosp, Div Renal, Dept Med, Beijing 100034, Peoples R China
2.Peking Univ First Hosp, Dept Endocrinol, Beijing 100034, Peoples R China
Recommended Citation
GB/T 7714
Chen, Min,Gao, Ying,Guo, Xiao-Hui,et al. Propylthiouracil-induced antineutrophil cytoplasmic antibody-associated vasculitis[J]. NATURE REVIEWS NEPHROLOGY,2012,8(8):476-483.
APA Chen, Min,Gao, Ying,Guo, Xiao-Hui,&Zhao, Ming-Hui.(2012).Propylthiouracil-induced antineutrophil cytoplasmic antibody-associated vasculitis.NATURE REVIEWS NEPHROLOGY,8(8),476-483.
MLA Chen, Min,et al."Propylthiouracil-induced antineutrophil cytoplasmic antibody-associated vasculitis".NATURE REVIEWS NEPHROLOGY 8.8(2012):476-483.
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