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Propylthiouracil-induced antineutrophil cytoplasmic antibody-associated vasculitis
Chen, Min1; Gao, Ying2; Guo, Xiao-Hui2; Zhao, Ming-Hui1
刊名NATURE REVIEWS NEPHROLOGY
2012-08-01
DOI10.1038/nrneph.2012.108
8期:8页:476-483
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Urology & Nephrology
研究领域[WOS]Urology & Nephrology
关键词[WOS]ANCA-ASSOCIATED VASCULITIDES ; SENSORINEURAL HEARING-LOSS ; DRUG-INDUCED VASCULITIS ; RAT BONE-MARROW ; TERM-FOLLOW-UP ; GRAVES-DISEASE ; ANTITHYROID DRUGS ; ANTIMYELOPEROXIDASE ANTIBODIES ; MPO-ANCA ; CRESCENTIC GLOMERULONEPHRITIS
英文摘要

Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) refers to a group of potentially life-threatening autoimmune diseases. A recent development in this field is the recognition that certain drugs can induce AAV. Among these agents, the drug most often implicated in causing disease is the commonly used antithyroid agent propylthiouracil (PTU). This Review provides an update on PTU-induced AAV. Clinical characteristics of PTU-induced AAV are similar to that of primary AAV, but usually have a milder course and better prognosis, provided early cessation of the disease-causing drug. PTU-induced ANCAs usually react to several components of myeloid granules, which is helpful in differentiating PTU-induced AAV from primary AAV. Early cessation of PTU is crucial in the treatment of PTU-induced AAV. The duration of immunosuppressive therapy might be shorter than in primary AAV, depending on the severity of organ damage, and maintenance therapy is not always necessary.

语种英语
WOS记录号WOS:000306828200009
项目编号2012CB517702 ; 30972733 ; 81021004
资助机构Chinese 973 project ; National Natural Science Fund
引用统计
被引频次:19[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61312
专题北京大学第一临床医学院_肾脏内科
北京大学第一临床医学院_内分泌内科
作者单位1.Peking Univ First Hosp, Div Renal, Dept Med, Beijing 100034, Peoples R China
2.Peking Univ First Hosp, Dept Endocrinol, Beijing 100034, Peoples R China
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GB/T 7714
Chen, Min,Gao, Ying,Guo, Xiao-Hui,et al. Propylthiouracil-induced antineutrophil cytoplasmic antibody-associated vasculitis[J]. NATURE REVIEWS NEPHROLOGY,2012,8(8):476-483.
APA Chen, Min,Gao, Ying,Guo, Xiao-Hui,&Zhao, Ming-Hui.(2012).Propylthiouracil-induced antineutrophil cytoplasmic antibody-associated vasculitis.NATURE REVIEWS NEPHROLOGY,8(8),476-483.
MLA Chen, Min,et al."Propylthiouracil-induced antineutrophil cytoplasmic antibody-associated vasculitis".NATURE REVIEWS NEPHROLOGY 8.8(2012):476-483.
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