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学科主题: 临床医学
题名:
Propylthiouracil-induced antineutrophil cytoplasmic antibody-associated vasculitis
作者: Chen, Min1; Gao, Ying2; Guo, Xiao-Hui2; Zhao, Ming-Hui1
刊名: NATURE REVIEWS NEPHROLOGY
发表日期: 2012-08-01
DOI: 10.1038/nrneph.2012.108
卷: 8, 期:8, 页:476-483
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
关键词[WOS]: ANCA-ASSOCIATED VASCULITIDES ; SENSORINEURAL HEARING-LOSS ; DRUG-INDUCED VASCULITIS ; RAT BONE-MARROW ; TERM-FOLLOW-UP ; GRAVES-DISEASE ; ANTITHYROID DRUGS ; ANTIMYELOPEROXIDASE ANTIBODIES ; MPO-ANCA ; CRESCENTIC GLOMERULONEPHRITIS
英文摘要:

Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) refers to a group of potentially life-threatening autoimmune diseases. A recent development in this field is the recognition that certain drugs can induce AAV. Among these agents, the drug most often implicated in causing disease is the commonly used antithyroid agent propylthiouracil (PTU). This Review provides an update on PTU-induced AAV. Clinical characteristics of PTU-induced AAV are similar to that of primary AAV, but usually have a milder course and better prognosis, provided early cessation of the disease-causing drug. PTU-induced ANCAs usually react to several components of myeloid granules, which is helpful in differentiating PTU-induced AAV from primary AAV. Early cessation of PTU is crucial in the treatment of PTU-induced AAV. The duration of immunosuppressive therapy might be shorter than in primary AAV, depending on the severity of organ damage, and maintenance therapy is not always necessary.

语种: 英语
所属项目编号: 2012CB517702 ; 30972733 ; 81021004
项目资助者: Chinese 973 project ; National Natural Science Fund
WOS记录号: WOS:000306828200009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61312
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: 1.Peking Univ First Hosp, Div Renal, Dept Med, Beijing 100034, Peoples R China
2.Peking Univ First Hosp, Dept Endocrinol, Beijing 100034, Peoples R China

Recommended Citation:
Chen, Min,Gao, Ying,Guo, Xiao-Hui,et al. Propylthiouracil-induced antineutrophil cytoplasmic antibody-associated vasculitis[J]. NATURE REVIEWS NEPHROLOGY,2012,8(8):476-483.
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