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学科主题: 临床医学
题名:
Frequency, Immunogenetics, and Clinical Characteristics of Latent Autoimmune Diabetes in China (LADA China Study) A Nationwide, Multicenter, Clinic-Based Cross-Sectional Study
作者: Zhou, Zhiguang1,2; Xiang, Yufei1,2; Ji, Linong3; Jia, Weiping4; Ning, Guang5; Huang, Gan1,2; Yang, Lin1,2; Lin, Jian1,2; Liu, Zhenqi6; Hagopian, William A.7; Leslie, R. David8; LADA China Study Grp
刊名: DIABETES
发表日期: 2013-02-01
DOI: 10.2337/db12-0207
卷: 62, 期:2, 页:543-550
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Endocrinology & Metabolism
研究领域[WOS]: Endocrinology & Metabolism
关键词[WOS]: GLUTAMIC-ACID DECARBOXYLASE ; GENETIC-CHARACTERISTICS ; ADULTS LADA ; HIGH-TITER ; TYPE-1 ; AUTOANTIBODIES ; PREVALENCE ; ANTIBODIES ; TRENDS ; CLASSIFICATION
英文摘要:

Adult non-insulin requiring diabetes includes latent autoimmune diabetes of adults (LADA), distinguished from type 2 diabetes by the presence of islet autoantibodies. LADA China determined the characteristics of Chinese LADA. This nationwide, multicenter, clinic-based cross-sectional study was conducted in 46 university-affiliated hospitals in 25 Chinese cities. All 4,880 ketosis-free diabetic patients (<1 year postdiagnosis, without insulin therapy for >6 months, aged >= 30 years) had GAD antibody (GADA) and HLA-DQ genotype measured centrally with clinical data collected locally. GADA-positive subjects were classified as LADA. Of the patients, 5.9% were GADA positive with LADA. LADA showed a north-south gradient. Compared with GADA-negative type 2 diabetes, LADA patients were leaner, with lower fasting C-peptide and less metabolic syndrome. Patients with high GADA titers are phenotypically different from those with low GADA titers, while only a higher HDL distinguished the latter from those with type 2 diabetes. HLA diabetes-susceptible haplotypes were more frequent in LADA, even in those with low-titer GADA. HLA diabetes-protective haplotypes were less frequent in LADA. Our study implicates universal immunogenetic effects, with some ethnic differences, in adult-onset autoimmune diabetes. Autoantibody positivity and titer could be important for LADA risk stratification and accurate therapeutic choice in clinical practice.

语种: 英语
所属项目编号: 201002002 ; IRT1195 ; 11JJ7005
项目资助者: European Foundation for the Study of Diabetes ; National Department Public Benefit (Health) Research Foundation of China ; Program for Changjiang Scholars and Innovative Research Team in University ; Hunan Provincial Natural Science Foundation of China
WOS记录号: WOS:000333665800002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61319
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Blizard Inst, Dept Diabet & Metab Med, London, England
2.Cent S Univ, Diabet Ctr, Inst Metab & Endocrinol, Minist Educ,Xiangya Hosp 2, Changsha, Hunan, Peoples R China
3.Cent S Univ, Minist Educ, Key Lab Diabet Immunol, Changsha, Hunan, Peoples R China
4.Peking Univ, Peoples Hosp, Dept Endocrinol & Metab, Beijing 100871, Peoples R China
5.Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Dept Endocrinol & Metab, Shanghai 200030, Peoples R China
6.Shanghai Jiao Tong Univ, Affiliated Ruijin Hosp, Dept Endocrinol & Metab, Shanghai 200030, Peoples R China
7.Univ Virginia Hlth Syst, Div Endocrinol & Metab, Dept Internal Med, Charlottesville, VA USA
8.Pacific Northwest Diabet Res Inst, Seattle, WA USA

Recommended Citation:
Zhou, Zhiguang,Xiang, Yufei,Ji, Linong,et al. Frequency, Immunogenetics, and Clinical Characteristics of Latent Autoimmune Diabetes in China (LADA China Study) A Nationwide, Multicenter, Clinic-Based Cross-Sectional Study[J]. DIABETES,2013,62(2):543-550.
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