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学科主题: 药学
题名:
Chemical synthesis, characterization and biological properties of a novel cyclic ADP-ribose analogue
作者: Wang, Pei; Zhang, Yan; Yang Zhen-Jun; Zhang Liang-Ren; Zhang Li-He
关键词: nucleotide ; analogues of cADPR ; calcium agonist ; stability
刊名: CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
发表日期: 2008-02-10
卷: 29, 期:2, 页:314-318
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
关键词[WOS]: CALCIUM-RELEASE ; CARBOCYCLIC-RIBOSE ; METABOLITES ; MIMICS
英文摘要:

For the investigation of the structure-activity relationship of the analogues of cyclic ADP-ribose (cADPR), a novel cyclic IDP-ribose analogue, cIDPRN, in which the northern ribose was replaced by N-carbobenzyloxy-alkylimine bridge was designed and synthesized. The enzymatic stability of cIDPRN was evaluated by the incubation with Jurkat T-lymphocytes for 0, 2 and 18 h. The result analyzed by capillary electrophoresis indicated that cIDPRN antagonized the hydrolysis, whereas cADPR was easily hydrolyzed. The Ca2+ signal release behavior was investigated in intact Jurkat T-lymphocytes by spectrofluorometer. It showed that cIDPRN induced calcium release either in extracellular Ca2+-containing or Ca2+-free condition. The result indicated that cIDPRN was a mild membrane-permeant agonist of cADPR/RyR signaling system. This study provided further information for understanding the effect of structure of northern ribose moiety of cIDPR on the calcium motivation activity.

语种: 中文
WOS记录号: WOS:000253139800021
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61323
Appears in Collections:北京大学药学院_期刊论文

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作者单位: Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China

Recommended Citation:
Wang, Pei,Zhang, Yan,Yang Zhen-Jun,et al. Chemical synthesis, characterization and biological properties of a novel cyclic ADP-ribose analogue[J]. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,2008,29(2):314-318.
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