IR@PKUHSC  > 北京大学第一临床医学院
学科主题临床医学
Comparison of pyogenic liver abscesses caused by hypermucoviscous Klebsiella pneumoniae and non-Klebsiella pneumoniae pathogens in Beijing: A retrospective analysis
Wang, Jing1,2; Yan, Yan3; Xue, Xinying4; Wang, Kaifei1; Shen, Dingxia1
关键词Liver abscess hypermucoviscosity Klebsiella pneumoniae magA rmpA aerobactin
刊名JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
2013-08-01
DOI10.1177/0300060513487645
41期:4页:1088-1097
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental ; Pharmacology & Pharmacy
资助者Capital Health Research and Development of Special Capital fund ; Capital Health Research and Development of Special Capital fund
研究领域[WOS]Research & Experimental Medicine ; Pharmacology & Pharmacy
关键词[WOS]CLINICAL CHARACTERISTICS ; VIRULENCE ; MAGA ; ENDOPHTHALMITIS ; ASSOCIATION ; APPEARANCE ; TAIWAN ; RMPA ; GENE
英文摘要

Objective: To perform a retrospective comparison of the clinical and radiological features of Klebsiella pneumoniae (KP)-associated and non-KP-associated pyogenic liver abscesses (PLA) in Chinese patients.

Methods: Patients with confirmed diagnoses of bacterial liver abscess at three Beijing hospitals were enrolled. Clinical isolates from liver abscesses were used to determine serology and expression of hypermucoviscosity genes. Basic clinical, ultrasonographic (US) and computed tomography (CT) data were recorded and compared between patients with KP- and non-KP-associated PLA.

Results: A total of 101 (77.10%) and 30 (22.90%) cases were due to KP and non-KP pathogens, respectively. Compared with the non-KP cohort, the KP cohort demonstrated a significantly higher incidence of underlying diabetes mellitus, and more gas-forming abscesses, as demonstrated by US and CT examinations. Prior abdominal surgery or chemoradiation therapy was significantly associated with non-KP cases. The non-KP group had a higher chance of a clear edge, compared with the KP group, on pre-contrast CT images.

Conclusion: KP and non-KP-associated PLA have distinctive risk factors and unique US and CT features, in Chinese patients.

语种英语
所属项目编号2011-2008-07
资助者Capital Health Research and Development of Special Capital fund ; Capital Health Research and Development of Special Capital fund
WOS记录号WOS:000322507100019
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61324
专题北京大学第一临床医学院
作者单位1.Chinese Peoples Liberat Army Gen Hosp, Dept Microbiol, Beijing 100853, Peoples R China
2.Capital Med Univ, Beijing Shijitan Hosp, Dept Clin Lab, Beijing, Peoples R China
3.Peking Univ, Dept Microbiol, Hosp 1, Beijing 100871, Peoples R China
4.Capital Med Univ, Beijing Shijitan Hosp, Dept Special Med Treatment Resp Dis, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Wang, Jing,Yan, Yan,Xue, Xinying,et al. Comparison of pyogenic liver abscesses caused by hypermucoviscous Klebsiella pneumoniae and non-Klebsiella pneumoniae pathogens in Beijing: A retrospective analysis[J]. JOURNAL OF INTERNATIONAL MEDICAL RESEARCH,2013,41(4):1088-1097.
APA Wang, Jing,Yan, Yan,Xue, Xinying,Wang, Kaifei,&Shen, Dingxia.(2013).Comparison of pyogenic liver abscesses caused by hypermucoviscous Klebsiella pneumoniae and non-Klebsiella pneumoniae pathogens in Beijing: A retrospective analysis.JOURNAL OF INTERNATIONAL MEDICAL RESEARCH,41(4),1088-1097.
MLA Wang, Jing,et al."Comparison of pyogenic liver abscesses caused by hypermucoviscous Klebsiella pneumoniae and non-Klebsiella pneumoniae pathogens in Beijing: A retrospective analysis".JOURNAL OF INTERNATIONAL MEDICAL RESEARCH 41.4(2013):1088-1097.
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