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学科主题: 临床医学
题名:
Comparison of pyogenic liver abscesses caused by hypermucoviscous Klebsiella pneumoniae and non-Klebsiella pneumoniae pathogens in Beijing: A retrospective analysis
作者: Wang, Jing1,2; Yan, Yan3; Xue, Xinying4; Wang, Kaifei1; Shen, Dingxia1
关键词: Liver abscess ; hypermucoviscosity ; Klebsiella pneumoniae ; magA ; rmpA ; aerobactin
刊名: JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
发表日期: 2013-08-01
DOI: 10.1177/0300060513487645
卷: 41, 期:4, 页:1088-1097
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental ; Pharmacology & Pharmacy
研究领域[WOS]: Research & Experimental Medicine ; Pharmacology & Pharmacy
关键词[WOS]: CLINICAL CHARACTERISTICS ; VIRULENCE ; MAGA ; ENDOPHTHALMITIS ; ASSOCIATION ; APPEARANCE ; TAIWAN ; RMPA ; GENE
英文摘要:

Objective: To perform a retrospective comparison of the clinical and radiological features of Klebsiella pneumoniae (KP)-associated and non-KP-associated pyogenic liver abscesses (PLA) in Chinese patients.

Methods: Patients with confirmed diagnoses of bacterial liver abscess at three Beijing hospitals were enrolled. Clinical isolates from liver abscesses were used to determine serology and expression of hypermucoviscosity genes. Basic clinical, ultrasonographic (US) and computed tomography (CT) data were recorded and compared between patients with KP- and non-KP-associated PLA.

Results: A total of 101 (77.10%) and 30 (22.90%) cases were due to KP and non-KP pathogens, respectively. Compared with the non-KP cohort, the KP cohort demonstrated a significantly higher incidence of underlying diabetes mellitus, and more gas-forming abscesses, as demonstrated by US and CT examinations. Prior abdominal surgery or chemoradiation therapy was significantly associated with non-KP cases. The non-KP group had a higher chance of a clear edge, compared with the KP group, on pre-contrast CT images.

Conclusion: KP and non-KP-associated PLA have distinctive risk factors and unique US and CT features, in Chinese patients.

语种: 英语
所属项目编号: 2011-2008-07
项目资助者: Capital Health Research and Development of Special Capital fund
WOS记录号: WOS:000322507100019
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61324
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: 1.Chinese Peoples Liberat Army Gen Hosp, Dept Microbiol, Beijing 100853, Peoples R China
2.Capital Med Univ, Beijing Shijitan Hosp, Dept Clin Lab, Beijing, Peoples R China
3.Peking Univ, Dept Microbiol, Hosp 1, Beijing 100871, Peoples R China
4.Capital Med Univ, Beijing Shijitan Hosp, Dept Special Med Treatment Resp Dis, Beijing, Peoples R China

Recommended Citation:
Wang, Jing,Yan, Yan,Xue, Xinying,et al. Comparison of pyogenic liver abscesses caused by hypermucoviscous Klebsiella pneumoniae and non-Klebsiella pneumoniae pathogens in Beijing: A retrospective analysis[J]. JOURNAL OF INTERNATIONAL MEDICAL RESEARCH,2013,41(4):1088-1097.
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