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Natural vitamin C intake and the risk of head and neck cancer: A pooled analysis in the International Head and Neck Cancer Epidemiology Consortium
Edefonti, Valeria1; Hashibe, Mia2,3; Parpinel, Maria4; Turati, Federica5,6; Serraino, Diego7; Matsuo, Keitaro8; Olshan, Andrew F.9,10; Zevallos, Jose P.11; Winn, Deborah M.12; Moysich, Kirsten13,14; Zhang, Zuo-Feng15; Morgenstern, Hal16,17; Levi, Fabio18; Kelsey, Karl19,20; McClean, Michael21; Bosetti, Cristina5; Galeone, Carlotta5; Schantz, Stimson22; Yu, Guo-Pei23; Boffetta, Paolo24; Amy Lee, Yuan-Chin25; Chuang, Shu-Chun26; La Vecchia, Carlo1; Decarli, Adriano1,6
关键词head and neck cancer INHANCE laryngeal cancer oral and pharyngeal cancer vitamin C
刊名INTERNATIONAL JOURNAL OF CANCER
2015-07-15
DOI10.1002/ijc.29388
137期:2页:448-462
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
资助者National Cancer Institute (NCI) ; Swiss Research Against Cancer ; Swiss Research Against Cancer/Oncosuisse ; NIH ; Scientific Research Grant from the Ministry of Education, Science, Sports, Culture and Technology of Japan ; Ministry of Health, Labor and Welfare of Japan ; Italian Ministry of Education ; Italian Association for Research on Cancer (AIRC) ; Italian League Against Cancer ; Italian Ministry of Research ; Alper Research Program for Environmental Genomics of the UCLA Jonsson Comprehensive Cancer Center ; Intramural Program of the NCI, NIH, United States ; Italian Foundation for Cancer Research (FIRC) ; National Cancer Institute (NCI) ; Swiss Research Against Cancer ; Swiss Research Against Cancer/Oncosuisse ; NIH ; Scientific Research Grant from the Ministry of Education, Science, Sports, Culture and Technology of Japan ; Ministry of Health, Labor and Welfare of Japan ; Italian Ministry of Education ; Italian Association for Research on Cancer (AIRC) ; Italian League Against Cancer ; Italian Ministry of Research ; Alper Research Program for Environmental Genomics of the UCLA Jonsson Comprehensive Cancer Center ; Intramural Program of the NCI, NIH, United States ; Italian Foundation for Cancer Research (FIRC)
研究领域[WOS]Oncology
关键词[WOS]UPPER-AERODIGESTIVE TRACT ; FOOD-FREQUENCY QUESTIONNAIRE ; SQUAMOUS-CELL CARCINOMA ; TOTAL-ENERGY-INTAKE ; PHARYNGEAL CANCER ; LARYNGEAL-CANCER ; VEGETABLE INTAKE ; PROSPECTIVE COHORT ; DIETARY PATTERNS ; ABSOLUTE INTAKE
英文摘要

Evidence of associations between single nutrients and head and neck cancer (HNC) is still more limited and less consistent than that for fruit and vegetables. However, clarification of the protective mechanisms of fruit and vegetables is important to our understanding of HNC etiology. We investigated the association between vitamin C intake from natural sources and cancer of the oral cavity/pharynx and larynx using individual-level pooled data from ten case-control studies (5,959 cases and 12,248 controls) participating in the International Head and Neck Cancer Epidemiology (INHANCE) consortium. After harmonization of study-specific exposure information via the residual method, adjusted odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were estimated using unconditional multiple logistic regression models on quintile categories of ′non-alcohol energy-adjusted′ vitamin C intake. In the presence of heterogeneity of the estimated ORs among studies, we derived those estimates from generalized linear mixed models. Higher intakes of vitamin C were inversely related to oral and pharyngeal (OR=0.54, 95% CI: 0.45-0.65, for the fifth quintile category versus the first one, p for trend<0.001) and laryngeal cancers (OR=0.52, 95% CI: 0.40-0.68, p for trend=0.006), although in the presence of heterogeneity among studies for both sites. Inverse associations were consistently observed for the anatomical subsites of oral and pharyngeal cancer, and across strata of age, sex, education, body mass index, tobacco, and alcohol, for both cancer sites. The inverse association of vitamin C intake from foods with HNC may reflect a protective effect on these cancers; however, we cannot rule out other explanations.

What′s new? A diet rich in fruits and vegetables is thought to offer protection against head and neck cancers (HNC). However, it has not been clear which specific nutrients might play a role in this effect. In this re-analysis of several previous studies, the authors found that a higher intake of vitamin C from natural sources was associated with a significantly lower risk of anatomical subsites of HNC.

语种英语
所属项目编号R03CA113157 ; NIDCR R03DE016611 ; KFS-700 ; OCS-1633 ; P50CA090388 ; R01DA011386 ; R03CA077954 ; T32CA009142 ; U01CA096134 ; R21ES011667 ; R01CA078609 ; R01CA100679 ; R01CA051845 ; 17015052 ; H20-002 ; PRIN 2009 X8YCBN
资助者National Cancer Institute (NCI) ; Swiss Research Against Cancer ; Swiss Research Against Cancer/Oncosuisse ; NIH ; Scientific Research Grant from the Ministry of Education, Science, Sports, Culture and Technology of Japan ; Ministry of Health, Labor and Welfare of Japan ; Italian Ministry of Education ; Italian Association for Research on Cancer (AIRC) ; Italian League Against Cancer ; Italian Ministry of Research ; Alper Research Program for Environmental Genomics of the UCLA Jonsson Comprehensive Cancer Center ; Intramural Program of the NCI, NIH, United States ; Italian Foundation for Cancer Research (FIRC) ; National Cancer Institute (NCI) ; Swiss Research Against Cancer ; Swiss Research Against Cancer/Oncosuisse ; NIH ; Scientific Research Grant from the Ministry of Education, Science, Sports, Culture and Technology of Japan ; Ministry of Health, Labor and Welfare of Japan ; Italian Ministry of Education ; Italian Association for Research on Cancer (AIRC) ; Italian League Against Cancer ; Italian Ministry of Research ; Alper Research Program for Environmental Genomics of the UCLA Jonsson Comprehensive Cancer Center ; Intramural Program of the NCI, NIH, United States ; Italian Foundation for Cancer Research (FIRC)
WOS记录号WOS:000354287600019
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61332
专题北京大学医学信息学中心
作者单位1.Mt Sinai Sch Med, Tisch Canc Inst, New York, NY USA
2.Univ Milan, Sez Stat Med & Biometria Giulio A Maccacaro, Dipartimento Sci Clin & Comunita, I-20133 Milan, Italy
3.Univ Utah, Sch Med, Dept Family & Prevent Med, Div Publ Hlth, Salt Lake City, UT 84112 USA
4.Univ Utah, Sch Med, Huntsman Canc Inst, Salt Lake City, UT USA
5.Univ Udine, Dept Med & Biol Sci, Inst Hyg & Epidemiol, I-33100 Udine, Italy
6.Ist Ric Farmacol Mario Negri, IRCCS, Dept Epidemiol, Milan, Italy
7.Fdn IRCSS Ist Nazl Tumori Milano, SC Stat Med Biometria & Bioinformat, Milan, Italy
8.IRCCS, CRO Aviano Natl Canc Inst, Unit Epidemiol & Biostat, Aviano, Italy
9.Kyushu Univ, Fac Med Sci, Dept Prevent Med, Kyushu, Japan
10.Univ N Carolina, Dept Epidemiol, Gillings Sch Global Publ Hlth, Chapel Hill, NC USA
11.Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA
12.Univ N Carolina, Dept Otolaryngol Head & Neck Surg, Chapel Hill, NC USA
13.NCI, Div Canc Control & Populat Sci, Bethesda, MD 20892 USA
14.Roswell Pk Canc Inst, Dept Canc Prevent & Control, Buffalo, NY 14263 USA
15.Roswell Pk Canc Inst, Dept Immunol, Buffalo, NY 14263 USA
16.Univ Calif Los Angeles, Sch Publ Hlth, Dept Epidemiol, Los Angeles, CA 90024 USA
17.Univ Michigan, Sch Publ Hlth, Dept Epidemiol & Environm Hlth Sci, Ann Arbor, MI 48109 USA
18.Univ Michigan, Ctr Comprehens Canc, Ann Arbor, MI 48109 USA
19.Univ Lausanne Hosp, Inst Social & Prevent Med IUMSP, Canc Epidemiol Unit, Lausanne, Switzerland
20.Brown Univ, Dept Pathol & Lab Med, Providence, RI 02912 USA
21.Brown Univ, Dept Epidemiol, Providence, RI 02912 USA
22.Boston Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA USA
23.New York Eye & Ear Infirm, Dept Otolaryngol, New York, NY 10003 USA
24.Peking Univ, Med Informat Ctr, Beijing, Peoples R China
25.Univ Utah, Sch Med, Dept Family & Prevent Med, Div Publ Hlth, Salt Lake City, UT 84112 USA
26.Natl Hlth Res Inst, Inst Populat Hlth Sci, Miaoli, Taiwan
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Edefonti, Valeria,Hashibe, Mia,Parpinel, Maria,et al. Natural vitamin C intake and the risk of head and neck cancer: A pooled analysis in the International Head and Neck Cancer Epidemiology Consortium[J]. INTERNATIONAL JOURNAL OF CANCER,2015,137(2):448-462.
APA Edefonti, Valeria.,Hashibe, Mia.,Parpinel, Maria.,Turati, Federica.,Serraino, Diego.,...&Decarli, Adriano.(2015).Natural vitamin C intake and the risk of head and neck cancer: A pooled analysis in the International Head and Neck Cancer Epidemiology Consortium.INTERNATIONAL JOURNAL OF CANCER,137(2),448-462.
MLA Edefonti, Valeria,et al."Natural vitamin C intake and the risk of head and neck cancer: A pooled analysis in the International Head and Neck Cancer Epidemiology Consortium".INTERNATIONAL JOURNAL OF CANCER 137.2(2015):448-462.
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