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学科主题临床医学
Elevated nocturnal and morning blood pressure in patients with obstructive sleep apnea syndrome
He Quan-ying2; Feng Jing1; Zhang Xi-long3; Liang Zong-an4; Huang Shao-guang5; Kang Jian6; Wang Guang-fa7; Zhang Li-qiang8; Ma Li-jun9; Wang Bei10; Lin Qi-chang11; Zhang Jin-nong12; Liu Hui-guo13; Luo Yuan-ming14; Liu Jian-hong15; Wang Shi16; Xiao Gao-hui17; Lu Gan18; Zhang Jin19; Feng Xue-wei20; Chen Bao-yuan1; Chinese Med Assoc
关键词obstructive sleep apnea syndrome blood pressure hypertension dipping polysomnography apnea-hypopnea index
刊名CHINESE MEDICAL JOURNAL
2012-05-20
DOI10.3760/cma.j.issn.0366-6999.2012.10.011
125期:10页:1740-1746
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
研究领域[WOS]General & Internal Medicine
关键词[WOS]CARDIOVASCULAR-DISEASE ; HYPERTENSIVE PATIENTS ; ASSOCIATION ; PREVALENCE ; RISK ; MULTICENTER ; MECHANISMS ; INSOMNIA ; DEATH ; TIME
英文摘要

Background The nocturnal nondipping and elevated morning blood pressure (BP) in patients with obstructive sleep apnea syndrome (OSAS) have not yet been well investigated in Chinese patients. This study aimed to describe the BP profile, and to elucidate the relationships between daytime BP and nighttime BP, and between evening BP and morning BP in patients with OSAS.

Methods Twenty teaching hospital sleep centers in China were organized by the Chinese Medical Association to participate in this study and 2297 patients were recruited between January 2004 and April 2006. BP assessments were made at four time points (daytime, evening, nighttime and morning) and polysomnography (PSG) was performed and subjects were classified into four groups by their apnea-hypopnea index (AHI): control, n=213 with AHI <5; mild, n=420 with AHI >= 5 and <15; moderate, n=460 with AHI >= 15 and <30; and severe, n=1204 with AHI SPSS 11.5 software package was used for statistical analysis and figure drawing.

Results All the average daytime, nighttime, evening and morning BPs were positively correlated with AHI and negatively correlated with nadir nocturnal oxygen saturation. The ratios of nighttime/daytime and morning/evening average BP were positively correlated with AHI. The ratio of nighttime/daytime systolic BP became a "reversed BP dipping" pattern until the classification reached severe, while the ratio of nighttime/daytime diastolic BP became reversed at moderate. Similarly, the ratio of morning/evening diastolic BP becomes reversed even at mild.

Conclusions OSAS may result in higher BP levels at all four time points. The ratios of nighttime/daytime and morning/evening BP increase with increased AHI. The increasing of diastolic BP, which is inclined to rise more quickly, is not parallel with increasing systolic BP. Chin Med J 2012;125(10):1740-1746

语种英语
所属项目编号30800507 ; 30770934
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
WOS记录号WOS:000305259500011
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61335
专题北京大学第二临床医学院_呼吸科
作者单位1.Tianjin Med Univ, Dept Resp Dis, Gen Hosp, Tianjin 300052, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Resp Dis, Beijing 100044, Peoples R China
3.Nanjing Med Univ, Affiliated Hosp 1, Dept Resp Dis, Nanjing 210029, Jiangsu, Peoples R China
4.Sichuan Univ, W China Hosp, Dept Resp Dis, Chengdu 610041, Sichuan, Peoples R China
5.Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Dept Resp Dis, Shanghai 200025, Peoples R China
6.China Med Univ, Affiliated Hosp 1, Dept Resp Dis, Shenyang 110001, Liaoning, Peoples R China
7.Peking Univ, Hosp 1, Dept Resp Dis, Beijing 100034, Peoples R China
8.Peking Univ, Hosp 3, Dept Resp Dis, Beijing 100191, Peoples R China
9.Henan Prov Peoples Hosp, Dept Resp Dis, Zhengzhou 450003, Henan, Peoples R China
10.Shanxi Med Univ, Affiliated Hosp 2, Dept Resp Dis, Taiyuan 030001, Shanxi, Peoples R China
11.Fujian Med Univ, Affiliated Hosp 1, Dept Resp Dis, Fuzhou 350005, Fujian, Peoples R China
12.Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Dept Resp Dis, Wuhan 430022, Hubei, Peoples R China
13.Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Resp Dis, Wuhan 430030, Hubei, Peoples R China
14.Guangzhou Med Coll, Affiliated Hosp 1, Guangzhou Inst Resp Dis, Guangzhou 510120, Guangdong, Peoples R China
15.Guangxi Zhuang Autonomous Reg Peoples Hosp, Dept Resp Dis, Nanning 530021, Guangxi, Peoples R China
16.Shenyang Med Coll, Cent Hosp, Dept Resp Dis, Shenyang 110024, Liaoning, Peoples R China
17.Beijing Gongan Hosp, Dept Resp Dis, Beijing 100006, Peoples R China
18.Jiangsu Senil Hosp, Dept Resp Dis, Nanjing 210024, Jiangsu, Peoples R China
19.Ningxia Med Coll, Affiliated Hosp, Dept Resp Dis, Yinchuan 750004, Ningxia, Peoples R China
20.China Med Univ, Affiliated Hosp 2, Dept Resp Dis, Shenyang 110004, Liaoning, Peoples R China
推荐引用方式
GB/T 7714
He Quan-ying,Feng Jing,Zhang Xi-long,et al. Elevated nocturnal and morning blood pressure in patients with obstructive sleep apnea syndrome[J]. CHINESE MEDICAL JOURNAL,2012,125(10):1740-1746.
APA He Quan-ying.,Feng Jing.,Zhang Xi-long.,Liang Zong-an.,Huang Shao-guang.,...&Chinese Med Assoc.(2012).Elevated nocturnal and morning blood pressure in patients with obstructive sleep apnea syndrome.CHINESE MEDICAL JOURNAL,125(10),1740-1746.
MLA He Quan-ying,et al."Elevated nocturnal and morning blood pressure in patients with obstructive sleep apnea syndrome".CHINESE MEDICAL JOURNAL 125.10(2012):1740-1746.
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