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学科主题: 药物依赖
题名:
R(-)-ketamine shows greater potency and longer lasting antidepressant effects than S (+)-ketamine
作者: Zhang, Ji-chun1; Li, Su-xia1,2; Hashimoto, Kenji1
关键词: Antidepressant ; Depression ; Ketamine ; R-ketamine ; S-ketamine ; NMDA receptor
刊名: PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
发表日期: 2014
DOI: 10.1016/j.pbb.2013.11.033
卷: 116, 页:137-141
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Behavioral Sciences ; Neurosciences ; Pharmacology & Pharmacy
研究领域[WOS]: Behavioral Sciences ; Neurosciences & Neurology ; Pharmacology & Pharmacy
关键词[WOS]: RESISTANT MAJOR DEPRESSION ; NICOTINIC ACETYLCHOLINE-RECEPTORS ; NMDA RECEPTOR ; MOOD DISORDERS ; THERAPEUTIC TARGET ; KETAMINE ; GLUTAMATE ; TRIAL ; ANTAGONIST ; MODULATORS
英文摘要:

The N-methyl-D-aspartate (NMDA) receptor antagonist ketamine is one of the most attractive antidepressants for treatment-resistant major depressive disorder (MOD). Ketamine (or RS (+/-)-ketamine) is a racemic mixture containing equal parts of R (-)-ketamine and S (+)-ketamine. In this study, we examined the effects of R- and S-ketamine on depression-like behavior in juvenile mice after neonatal dexamethasone (DEX) exposure. In the tail suspension test (TST) and forced swimming test (FST), both isomers of ketamine significantly attenuated the increase in immobility time, seen in DEX-treated juvenile mice at 27 and 29 h respectively, after ketamine injections. In the 1% sucrose preference test (SPT), both isomers significantly attenuated the reduced preference for 1% sucrose consumption in DEX-treated juvenile mice, 48 h after a ketamine injection. Interestingly, when immobility times were tested by the TST and FST at day 7, R-ketamine, but not S-ketamine, significantly lowered the increases in immobility seen in DEX-treated juvenile mice. This study shows that a single dose of R-ketamine produced rapid and long-lasting antidepressant effects in juvenile mice exposed neonatally to DEX. Therefore, R-ketamine appears to be a potent and safe antidepressant relative to S-ketamine, since R-ketamine may be free of psychotomimetic side effects. (C) 2013 Elsevier Inc. All rights reserved.

语种: 英语
所属项目编号: 24116006
项目资助者: Innovative Areas of the Ministry of Education, Culture, Sports, Science and Technology, Japan ; JSPS Invitation Fellowship Program for Research in Japan (Long Term)
WOS记录号: WOS:000330914500018
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61338
Appears in Collections:中国药物依赖性研究所_期刊论文

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作者单位: 1.Chiba Univ Ctr Forens Mental Hlth, Div Clin Neurosci, Chiba 2608670, Japan
2.Peking Univ, Natl Inst Drug Dependence, Beijing 100871, Peoples R China

Recommended Citation:
Zhang, Ji-chun,Li, Su-xia,Hashimoto, Kenji. R(-)-ketamine shows greater potency and longer lasting antidepressant effects than S (+)-ketamine[J]. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,2014,116:137-141.
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