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学科主题: 临床医学
题名:
An Outbreak of a Nosocomial NDM-1-Producing Klebsiella pneumoniae ST147 at a Teaching Hospital in Mainland China
作者: Wang, Xiaojuan1; Xu, Xiuli2; Li, Zongwei3; Chen, Hongbin1; Wang, Qi1; Yang, Peihong2; Zhao, Chunjiang1; Ni, Ming3; Wang, Hui1
刊名: MICROBIAL DRUG RESISTANCE
发表日期: 2014-04-01
DOI: 10.1089/mdr.2013.0100
卷: 20, 期:2, 页:144-149
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Infectious Diseases ; Microbiology ; Pharmacology & Pharmacy
研究领域[WOS]: Infectious Diseases ; Microbiology ; Pharmacology & Pharmacy
关键词[WOS]: CARBAPENEM-RESISTANT ENTEROBACTERIACEAE ; BETA-LACTAMASES ; BLA(NDM-1) ; SEQUENCE ; BAUMANNII ; EMERGENCE ; GENE
英文摘要:

A total of 1,870 nonduplicate clinical Enterobacteriaceae from 13 teaching hospitals located in 11 provinces of mainland China from 2011 to 2012 were screened for the presence of the bla(NDM) gene. The high-throughput MiSeq sequencing method and comparative genomics were used to analyze the genetic environment of bla(NDM) among these isolates. Three bla(NDM-1)-carrying Klebsiella pneumoniae (0.16%, 3/1,870), isolated from a teaching hospital in Xi′an, exhibited high levels of resistance to all -lactams, but remained susceptible to amikacin, tigecycline, and polymyxin B. These three isolates, belonging to ST147, presented an identical pulsed-field gel electrophoresis pattern. The IncX3 plasmid, pNDM-SX04 (KC876051) showed 99% identity with plasmid pNDM-HN380 (JX104760). Comparative analysis of the genetic environment of bla(NDM-1) with previously published plasmids revealed the same 7,830-bp basic mobile element, which may have been derived from Acinetobacter spp. Partial ISAba125, ISAba125 promoter, bla(NDM-1), and ble(MBL) could serve as the minimal mobile vehicle facilitating horizontal transfer of the bla(NDM-1) gene. To our knowledge, this is the first report of an outbreak of bla(NDM-1)-carrying ST147 K. pneumoniae. Although the prevalence spread by the bla(NDM-1) gene prevalence is at a low frequency in mainland China, a dynamic national surveillance of this gene is needed due to its potential transferability.

语种: 英语
所属项目编号: 5122041 ; 20110001110043 ; KZ201210025025 ; NCET-10-0205
项目资助者: Beijing Natural Science Foundation ; Research Found for the Doctoral Program of Higher Education of China (RFDP) ; Beijing City Board of Education Science and technology key project ; Trans-Century Training Programme Foundation for the Talents by the State Education Commission
WOS记录号: WOS:000333170400008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61341
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Peking Univ, Peoples Hosp, Dept Clin Lab, Beijing 100044, Peoples R China
2.Fourth Mil Med Univ, Xijing Hosp, Dept Clin Lab, Xian 710032, Peoples R China
3.Beijing Inst Radiat Med, Dept Bioinformat, Beijing, Peoples R China

Recommended Citation:
Wang, Xiaojuan,Xu, Xiuli,Li, Zongwei,et al. An Outbreak of a Nosocomial NDM-1-Producing Klebsiella pneumoniae ST147 at a Teaching Hospital in Mainland China[J]. MICROBIAL DRUG RESISTANCE,2014,20(2):144-149.
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