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Biotransformation of arenobufagin and cinobufotalin by Alternaria alternata
Zhang, Xing1,2; Ye, Min1; Dong, Yin-Hui3; Hu, Hong-Bo3; Tao, Si-Jia4; Chen, Guang-Tong5; Yin, Jun2; Guo, De-An1,4
关键词Arenobufagin cinobufotalin biotransformation Alternaria alternata isomerization
刊名BIOCATALYSIS AND BIOTRANSFORMATION
2011-03-01
DOI10.3109/10242422.2011.578248
29期:2-3页:96-101
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology
研究领域[WOS]Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology
关键词[WOS]CYTOTOXIC BUFADIENOLIDES ; MICROBIAL TRANSFORMATION ; CATHARANTHUS-ROSEUS ; CINOBUFAGIN ; CHROMATOGRAPHY ; HYDROXYLATION ; PURIFICATION ; BUFALIN ; NMR
英文摘要

The biotransformation of arenobufagin (1) and cinobufotalin (2), isolated from the natural medicine Chan Su, by Alternaria alternata AS 3.4578 was carried out. Incubation of 1 and 2 afforded six metabolites: 3-oxo-arenobufagin (1a), psi-bufarenogin (1b), 3-oxo-psi-bufarenogin (1c), 3-oxo-Delta(4)-derivative of cinobufotalin (2a), 3-oxo-cinobufotalin (2b) and 12 beta-hydroxycinobufotalin (2c). Among them, metabolites 1a, 1c and 2c are new compounds and their structures were characterized on the basis of their spectroscopic data (NMR, MS and IR). Compounds 1, 2, 1b, 2a and 2b were evaluated for their cytotoxicity against HepG2 and MCF-7 human cancer cells, and all of them showed significant inhibitory activities.

语种英语
WOS记录号WOS:000290868200008
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61344
专题北京大学药学院
作者单位1.Med Sch Nantong Univ, Nantong, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
3.Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Shenyang, Peoples R China
4.China Agr Univ, Coll Food Sci & Nutr Engn, Beijing 100094, Peoples R China
5.Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai Inst Mat Med, Shanghai, Peoples R China
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GB/T 7714
Zhang, Xing,Ye, Min,Dong, Yin-Hui,et al. Biotransformation of arenobufagin and cinobufotalin by Alternaria alternata[J]. BIOCATALYSIS AND BIOTRANSFORMATION,2011,29(2-3):96-101.
APA Zhang, Xing.,Ye, Min.,Dong, Yin-Hui.,Hu, Hong-Bo.,Tao, Si-Jia.,...&Guo, De-An.(2011).Biotransformation of arenobufagin and cinobufotalin by Alternaria alternata.BIOCATALYSIS AND BIOTRANSFORMATION,29(2-3),96-101.
MLA Zhang, Xing,et al."Biotransformation of arenobufagin and cinobufotalin by Alternaria alternata".BIOCATALYSIS AND BIOTRANSFORMATION 29.2-3(2011):96-101.
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