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学科主题: 基础医学
题名:
Role of pancreatic-derived factor in type 2 diabetes: evidence from pancreatic beta cells and liver
作者: Wang, Chunjiong1; Burkhardt, Brant R.2; Guan, Youfei1; Yang, Jichun1
关键词: insulin resistance ; insulin secretion ; lipogenesis ; PANDER
刊名: NUTRITION REVIEWS
发表日期: 2012-02-01
DOI: 10.1111/j.1753-4887.2011.00457.x
卷: 70, 期:2, 页:100-106
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Nutrition & Dietetics
研究领域[WOS]: Nutrition & Dietetics
关键词[WOS]: FACTOR PANDER ; INITIAL-CHARACTERIZATION ; FASTING HYPERGLYCEMIA ; INSULIN-RESISTANCE ; HIGH GLUCOSE ; FACTOR FAM3B ; ISLETS ; EXPRESSION ; CYTOKINE ; APOPTOSIS
英文摘要:

Pancreatic-derived factor (PANDER) is a cytokine-like protein that is highly expressed in pancreatic islets. In vitro, PANDER pretreatment or viral-mediated overexpression promotes apoptosis of islet beta cells. Under conditions of insulin resistance, chronic hyperglycemia potently activates PANDER expression and stimulates the cosecretion of insulin and PANDER in beta cells. PANDER binds to the liver cell membrane and induces insulin resistance, resulting in increased gluconeogenesis. Recently, PANDER was found to be expressed in rodent and human liver, and its expression is increased in the liver of diabetic mice and rats. Hepatic overexpression of PANDER promotes lipogenesis in the liver and induces insulin resistance in C57BL/6 mice, whereas the inactivation of hepatic PANDER markedly reduces steatosis, insulin resistance, and hyperglycemia in db/db mice. PANDER deficiency protects mice from high-fat-diet-induced hyperglycemia by decreasing gluconeogenesis in the liver. In summary, PANDER plays an important role in the progression of type 2 diabetes by negatively regulating islet beta-cell function and insulin sensitivity in the liver.

语种: 英语
所属项目编号: 81170791 ; 30870995 ; 30890041 81170791 ; 7122107
项目资助者: Natural Science Foundation of China ; Ministry of Education of China ; Beijing Natural Science Foundation
WOS记录号: WOS:000299779000003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61349
Appears in Collections:基础医学院_心血管所_期刊论文

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作者单位: 1.Peking Univ, Dept Physiol & Pathophysiol, Hlth Sci Ctr, Key Lab Mol Cardiovasc Sci, Beijing 100191, Peoples R China
2.Univ S Florida, Dept Cell Biol Microbiol & Mol Biol, Tampa, FL USA

Recommended Citation:
Wang, Chunjiong,Burkhardt, Brant R.,Guan, Youfei,et al. Role of pancreatic-derived factor in type 2 diabetes: evidence from pancreatic beta cells and liver[J]. NUTRITION REVIEWS,2012,70(2):100-106.
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