北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 基础医学院  > 病原生物学系  > 期刊论文
学科主题: 基础医学
题名:
Salmonella paratyphi C: Genetic Divergence from Salmonella choleraesuis and Pathogenic Convergence with Salmonella typhi
作者: Liu, Wei-Qiao1,2; Feng, Ye3,4; Wang, Yan2; Zou, Qing-Hua5; Chen, Fang5; Guo, Ji-Tao5; Peng, Yi-Hong5; Jin, Yan2; Li, Yong-Guo6; Hu, Song-Nian3,4; Johnston, Randal N.7; Liu, Gui-Rong1,2,5; Liu, Shu-Lin1,2,5,6
刊名: PLOS ONE
发表日期: 2009-02-20
DOI: 10.1371/journal.pone.0004510
卷: 4, 期:2
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
英文摘要:

Background: Although over 1400 Salmonella serovars cause usually self-limited gastroenteritis in humans, a few, e. g., Salmonella typhi and S. paratyphi C, cause typhoid, a potentially fatal systemic infection. It is not known whether the typhoid agents have evolved from a common ancestor (by divergent processes) or acquired similar pathogenic traits independently (by convergent processes). Comparison of different typhoid agents with non-typhoidal Salmonella lineages will provide excellent models for studies on how similar pathogens might have evolved.

Methodologies/Principal Findings: We sequenced a strain of S. paratyphi C, RKS4594, and compared it with previously sequenced Salmonella strains. RKS4594 contains a chromosome of 4,833,080 bp and a plasmid of 55,414 bp. We predicted 4,640 intact coding sequences (4,578 in the chromosome and 62 in the plasmid) and 152 pseudogenes (149 in the chromosome and 3 in the plasmid). RKS4594 shares as many as 4346 of the 4,640 genes with a strain of S. choleraesuis, which is primarily a swine pathogen, but only 4008 genes with another human-adapted typhoid agent, S. typhi. Comparison of 3691 genes shared by all six sequenced Salmonella strains placed S. paratyphi C and S. choleraesuis together at one end, and S. typhi at the opposite end, of the phylogenetic tree, demonstrating separate ancestries of the human-adapted typhoid agents. S. paratyphi C seemed to have suffered enormous selection pressures during its adaptation to man as suggested by the differential nucleotide substitutions and different sets of pseudogenes, between S. paratyphi C and S. choleraesuis.

Conclusions: S. paratyphi C does not share a common ancestor with other human-adapted typhoid agents, supporting the convergent evolution model of the typhoid agents. S. paratyphi C has diverged from a common ancestor with S. choleraesuis by accumulating genomic novelty during adaptation to man.

语种: 英语
所属项目编号: NSFC30370774 ; NSFC30870098 ; 20030001029 ; Discovery Grant
项目资助者: Canadian Institutes of Health Research ; Harbin Medical University ; National Natural Science Foundation of China ; Peking University Health Science Center ; Specialized Research Fund for the Doctoral Program of Higher Education ; Natural Sciences and Engineering Research Council of Canada
WOS记录号: WOS:000265486200003
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61357
Appears in Collections:基础医学院_病原生物学系_期刊论文

Files in This Item:
File Name/ File Size Content Type Version Access License
Salmonella paratyphi C Genetic Divergence from Salmonella choleraesuis and Pathogenic Convergence with Salmonella typhi.pdf(472KB)期刊论文出版稿限制开放 联系获取全文

作者单位: 1.Harbin Med Coll, Genom Res Ctr, Harbin, Peoples R China
2.Univ Calgary, Calgary, AB T2N 1N4, Canada
3.Zhejiang Univ, JD Watson Inst Genome Sci, Hangzhou, Peoples R China
4.Chinese Acad Sci, Beijing Inst Genom, Beijing 100864, Peoples R China
5.Peking Univ, Hlth Sci Ctr, Dept Microbiol, Beijing, Peoples R China
6.Harbin Med Coll, Hosp 1, Dept Infect Dis, Harbin, Peoples R China
7.Univ Calgary, Dept Biochem & Mol Biol, Calgary, AB T2N 1N4, Canada

Recommended Citation:
Liu, Wei-Qiao,Feng, Ye,Wang, Yan,et al. Salmonella paratyphi C: Genetic Divergence from Salmonella choleraesuis and Pathogenic Convergence with Salmonella typhi[J]. PLOS ONE,2009,4(2).
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Liu, Wei-Qiao]'s Articles
[Feng, Ye]'s Articles
[Wang, Yan]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Liu, Wei-Qiao]‘s Articles
[Feng, Ye]‘s Articles
[Wang, Yan]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace