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学科主题: 基础医学
题名:
Salmonella paratyphi C: Genetic Divergence from Salmonella choleraesuis and Pathogenic Convergence with Salmonella typhi
作者: Liu, Wei-Qiao1,2; Feng, Ye3,4; Wang, Yan2; Zou, Qing-Hua5; Chen, Fang5; Guo, Ji-Tao5; Peng, Yi-Hong5; Jin, Yan2; Li, Yong-Guo6; Hu, Song-Nian3,4; Johnston, Randal N.7; Liu, Gui-Rong1,2,5; Liu, Shu-Lin1,2,5,6
刊名: PLOS ONE
发表日期: 2009-02-20
DOI: 10.1371/journal.pone.0004510
卷: 4, 期:2
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
英文摘要:

Background: Although over 1400 Salmonella serovars cause usually self-limited gastroenteritis in humans, a few, e. g., Salmonella typhi and S. paratyphi C, cause typhoid, a potentially fatal systemic infection. It is not known whether the typhoid agents have evolved from a common ancestor (by divergent processes) or acquired similar pathogenic traits independently (by convergent processes). Comparison of different typhoid agents with non-typhoidal Salmonella lineages will provide excellent models for studies on how similar pathogens might have evolved.

Methodologies/Principal Findings: We sequenced a strain of S. paratyphi C, RKS4594, and compared it with previously sequenced Salmonella strains. RKS4594 contains a chromosome of 4,833,080 bp and a plasmid of 55,414 bp. We predicted 4,640 intact coding sequences (4,578 in the chromosome and 62 in the plasmid) and 152 pseudogenes (149 in the chromosome and 3 in the plasmid). RKS4594 shares as many as 4346 of the 4,640 genes with a strain of S. choleraesuis, which is primarily a swine pathogen, but only 4008 genes with another human-adapted typhoid agent, S. typhi. Comparison of 3691 genes shared by all six sequenced Salmonella strains placed S. paratyphi C and S. choleraesuis together at one end, and S. typhi at the opposite end, of the phylogenetic tree, demonstrating separate ancestries of the human-adapted typhoid agents. S. paratyphi C seemed to have suffered enormous selection pressures during its adaptation to man as suggested by the differential nucleotide substitutions and different sets of pseudogenes, between S. paratyphi C and S. choleraesuis.

Conclusions: S. paratyphi C does not share a common ancestor with other human-adapted typhoid agents, supporting the convergent evolution model of the typhoid agents. S. paratyphi C has diverged from a common ancestor with S. choleraesuis by accumulating genomic novelty during adaptation to man.

语种: 英语
所属项目编号: NSFC30370774 ; NSFC30870098 ; 20030001029 ; Discovery Grant
项目资助者: Canadian Institutes of Health Research ; Harbin Medical University ; National Natural Science Foundation of China ; Peking University Health Science Center ; Specialized Research Fund for the Doctoral Program of Higher Education ; Natural Sciences and Engineering Research Council of Canada
WOS记录号: WOS:000265486200003
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61357
Appears in Collections:基础医学院_病原生物学系_期刊论文

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作者单位: 1.Harbin Med Coll, Genom Res Ctr, Harbin, Peoples R China
2.Univ Calgary, Calgary, AB T2N 1N4, Canada
3.Zhejiang Univ, JD Watson Inst Genome Sci, Hangzhou, Peoples R China
4.Chinese Acad Sci, Beijing Inst Genom, Beijing 100864, Peoples R China
5.Peking Univ, Hlth Sci Ctr, Dept Microbiol, Beijing, Peoples R China
6.Harbin Med Coll, Hosp 1, Dept Infect Dis, Harbin, Peoples R China
7.Univ Calgary, Dept Biochem & Mol Biol, Calgary, AB T2N 1N4, Canada

Recommended Citation:
Liu, Wei-Qiao,Feng, Ye,Wang, Yan,et al. Salmonella paratyphi C: Genetic Divergence from Salmonella choleraesuis and Pathogenic Convergence with Salmonella typhi[J]. PLOS ONE,2009,4(2).
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