北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学公共卫生学院  > 期刊论文
学科主题: 公共卫生
题名:
ROR2 gene is associated with risk of non-syndromic cleft palate in an Asian population
作者: Wang Hong1; Hetmanski, Jacqueline B.2; Ruczinski, Ingo3; Liang, Kung Yee4,5; Fallin, M. Daniele2; Redett, Richard J.6; Raymond, Gerald V.7; Chou, Yah-Huei Wu10; Chen, Philip Kuo-Ting11; Yeow, Vincent12; Chong, Samuel S.13; Cheah, Felicia S. H.13; Jabs, Ethylin Wang8,14; Scott, Alan F.9; Beaty, Terri H.2
关键词: receptor tyrosine kinase-like orphan receptor 2 ; cleft lip ; cleft palate ; association ; transmission disequilibrium test
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2012-02-05
DOI: 10.3760/cma.j.issn.0366-6999.2012.03.014
卷: 125, 期:3, 页:476-480
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: GENOME-WIDE ASSOCIATION ; ROBINOW-SYNDROME ; LIP ; FAMILY ; LOCI ; MUTATIONS ; VARIANTS ; LINKAGE ; MODEL ; SCAN
英文摘要:

Background The receptor tyrosine kinase-like orphan receptor 2 (ROR2) gene has been recently shown to play important roles in palatal development in animal models and resides in the chromosomal region linked to non syndromic cleft lip with or without cleft palate in humans. The aim of this study was to investigate the possible association between ROR2 gene and non-syndromic oral clefts.

Methods Here we tested 38 eligible single-nucleotide polymorphisms (SNPs) in ROR2 gene in 297 non-syndromic cleft lip with or without cleft palate and in 82 non-syndromic cleft palate case parent trios recruited from Asia and Maryland. Family Based Association Test was used to test for deviation from Mendelian inheritance. Plink software was used to test potential parent of origin effect. Possible maternally mediated in utero effects were assessed using the TRlad Multi-Marker approach under an assumption of mating symmetry in the population.

Results Significant evidence of linkage and association was shown for 3 SNPs (rs7858435, rs10820914 and rs3905385) among 57 Asian non-syndromic cleft palate trios in Family Based Association Tests. P values for these 3 SNPs equaled to 0.000068, 0.000115 and 0.000464 respectively which were all less than the significance level (0.05/38=0.0013) adjusted by strict Bonferroni correction. Relevant odds ratios for the risk allele were 3.42 (1.80-6.50), 3.45 (1.75-6.67) and 2.94 (1.56-5.56), respectively. Statistical evidence of linkage and association was not shown for study groups other than non-syndromic cleft palate. Neither evidence for parent-of-origin nor maternal genotypic effect was shown for any of the ROR2 markers in our analysis for all study groups.

Conclusion Our results provided evidence of linkage and association between the ROR2 gene and a gene controlling risk to non-syndromic cleft palate. Chin Med J 2012;125(3):476-480

语种: 英语
所属项目编号: R21-DE-013707 ; R01-DE-014581 ; D43-TW006176
项目资助者: National Institute of Dental &amp ; Craniofacial Research ; Fogarty Institution
WOS记录号: WOS:000300749600014
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61358
Appears in Collections:北京大学公共卫生学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Mt Sinai Sch Med, New York, NY USA
2.Natl Yang Ming Univ, Inst Genome Sci, Taipei 112, Taiwan
3.Chang Gung Mem Hosp, Dept Med Res, Tao Yuan, Taiwan
4.Chang Gung Mem Hosp, Craniofacial Ctr, Tao Yuan, Taiwan
5.Natl Yang Ming Univ, Dept Life Sci, Taipei 112, Taiwan
6.Peking Univ, Dept Epidemiol & Biostat, Sch Publ Hlth, Beijing 100191, Peoples R China
7.Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA
8.Johns Hopkins Bloomberg Sch Publ Hlth, Dept Biostat, Baltimore, MD USA
9.Johns Hopkins Univ, Sch Med, Dept Surg, Baltimore, MD 21205 USA
10.Johns Hopkins Univ, Sch Med, Kennedy Krieger Inst, Baltimore, MD USA
11.Johns Hopkins Univ, Sch Med, Dept Pediat, Baltimore, MD 21205 USA
12.Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA
13.KK Womens & Childrens Hosp, Dept Plast Reconstruct & Aesthet Surg, Singapore, Singapore
14.Natl Univ Singapore, Dept Pediat, Singapore 117548, Singapore

Recommended Citation:
Wang Hong,Hetmanski, Jacqueline B.,Ruczinski, Ingo,et al. ROR2 gene is associated with risk of non-syndromic cleft palate in an Asian population[J]. CHINESE MEDICAL JOURNAL,2012,125(3):476-480.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Wang Hong]'s Articles
[Hetmanski, Jacqueline B.]'s Articles
[Ruczinski, Ingo]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Wang Hong]‘s Articles
[Hetmanski, Jacqueline B.]‘s Articles
[Ruczinski, Ingo]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace