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学科主题: 临床医学
题名:
Cyclophosphamide reduces dectin-1 expression in the lungs of naive and Aspergillus fumigatus-infected mice
作者: Yang, Jianxun; Lu, Qiaoyun; Liu, Wan; Wan, Zhe; Wang, Xiaohong; Li, Ruoyu
关键词: Aspergillus fumigatus ; dectin-1 ; cyclophosphamide
刊名: MEDICAL MYCOLOGY
发表日期: 2010-03-01
DOI: 10.3109/13693780903136887
卷: 48, 期:2, 页:303-309
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Mycology ; Veterinary Sciences
研究领域[WOS]: Mycology ; Veterinary Sciences
关键词[WOS]: BETA-GLUCAN RECEPTOR ; TOLL-LIKE RECEPTOR-2 ; PULMONARY ASPERGILLOSIS ; INVASIVE ASPERGILLOSIS ; PATTERN-RECOGNITION ; IMMUNE RECOGNITION ; FUNGAL PATHOGENS ; MACROPHAGES ; INNATE ; DEFENSE
英文摘要:

Aspergillus fumigatus is an important opportunistic fungal pathogen. Patients treated with chemotherapeutic agent such as cyclophosphamide are susceptible to invasive pulmonary aspergillosis. Dectin-1 is a pattern recognition receptor critically involved in immune responses to A. fumigatus. Therefore, we tested whether cyclophosphamide treatment could cause alterations in dectin-1 expression in the lung, which could contribute to invasive pulmonary Aspergillus infections in patients. We established a murine A. fumigatus infectious model to investigate the kinetics of dectin-1 expression in lung tissues in the presence or absence of cyclophosphamide treatment. During infection, dectin-1 expression was strikingly increased in immunocompetent mice infected with A. fumigatus as compared to those in a non-infected control group. In vitro macrophages stimulated with heat-inactivated A. fumigatus conidia expressed a significantly elevated level of dectin-1. Infected mice treated with cyclophosphamide showed decreased levels of dectin-1 and a higher fungal burden in the lung than the infected mice without cyclophosphamide treatment. These results suggest that dectin-1 is involved in host defense against A. fumigatus infection and that suppression of dectin-1 expression caused by cyclophosphamide may contribute to susceptibility to infections caused by this fungus in the immunocompromised host.

语种: 英语
项目资助者: Higher Education of China, Ministry of Education
WOS记录号: WOS:000274879300012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61369
Appears in Collections:北京大学第一临床医学院_皮肤性病科_期刊论文

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作者单位: Peking Univ, Hosp 1, Dept Dermatol, Res Ctr Med Mycol, Beijing 100034, Peoples R China

Recommended Citation:
Yang, Jianxun,Lu, Qiaoyun,Liu, Wan,et al. Cyclophosphamide reduces dectin-1 expression in the lungs of naive and Aspergillus fumigatus-infected mice[J]. MEDICAL MYCOLOGY,2010,48(2):303-309.
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