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学科主题: 临床医学
题名:
Safety of infliximab therapy in rheumatoid arthritis patients with previous exposure to hepatitis B virus
作者: Zhang, Xuewu1; Zhang, Fengchun2; Wu, Donghai3; Bao, Chunde4; Zhu, Ping5; Zhang, Xiao6; Huang, Cibo7; He, DongYi8; Tao, Yi9; Fang, Yongfei10; Gu, Jieruo11; Wu, Huaxiang12; Sun, Lingyun13; Yang, Xiuyan14; Huang, Feng15; Xu, Huji16; Zhao, Dongbao17; Zhang, Miaojia18; Zheng, Yi19; Li, Zhanguo1
关键词: HBV infection ; infliximab ; rheumatoid arthritis
刊名: INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
发表日期: 2013-08-01
DOI: 10.1111/1756-185X.12125
卷: 16, 期:4, 页:408-412
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Rheumatology
研究领域[WOS]: Rheumatology
关键词[WOS]: ALPHA THERAPY ; PROPHYLAXIS ; INFECTIONS ; GUIDELINES ; EFFICACY ; DRUGS
英文摘要:

Objective: To evaluate the safety of tumor necrosis factor-alpha (TNF-alpha) monoclonal antibody (infliximab) therapy in patients with rheumatoid arthritis (RA) and previous exposure to hepatitis B virus (HBV) who had normal liver function.

Methods: This is a retrospective study from a 26-week, prospective, multicenter trial in 234 patients with RA who received infusions of infliximab (3 mg/kg at week 0, 2, 6, 14 and 22). The medical records of these patients were reviewed, including the information on disease duration, laboratory tests and HBV markers. The data on liver function during the study was analyzed, as well as comparison between patients with previous exposure to HBV and patients without such exposure.

Results: Forty-one patients with previous exposure to HBV were HBsAg(-). Forty patients had normal alanine aminotransferase (ALT) and aspartate aminotransferase (AST) and only one patient with positive anti-HBc showed an elevated ALT level before administration of infliximab, and had a further increase of ALT level at week 14, but decreased thereafter. The average ALT and AST levels rose slightly during the treatment but remained in normal range and the differences were insignificant compared with baseline. There was no statistically significant difference in the incidence of liver function abnormalities during the treatment of infliximab between the patients with previous exposure to HBV and those without such exposure.

Conclusion: In patients with RA and previous exposure to HBV but with a negative HBsAg and normal liver function at baseline, liver function abnormalities were not observed during infliximab treatment.

语种: 英语
WOS记录号: WOS:000323721600008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61374
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Beijing Hosp, Dept Rheumatol & Immunol, Beijing, Peoples R China
2.Peking Univ, Dept Rheumatol & Immunol, Peoples Hosp, Beijing 100044, Peoples R China
3.Beijing Union Med Coll Hosp, Dept Rheumatol & Immunol, Beijing, Peoples R China
4.China Japan Friendship Hosp, Dept Rheumatol & Immunol, Beijing, Peoples R China
5.Shanghai Jiao Tong Univ, Renji Hosp, Dept Rheumatol & Immunol, Shanghai 200030, Peoples R China
6.Fourth Mil Med Univ, Xijing Hosp, Dept Rheumatol & Immunol, Xian 710032, Peoples R China
7.Guangdong Prov Peoples Hosp, Dept Rheumatol & Immunol, Guangzhou, Guangdong, Peoples R China
8.Shanghai Guanghua Hosp, Dept Rheumatol & Immunol, Shanghai, Peoples R China
9.Guangzhou Med Univ, Affiliated Hosp 2, Dept Rheumatol & Immunol, Guangzhou, Guangdong, Peoples R China
10.Third Mil Med Univ, Xinan Affiliated Hosp, Dept Rheumatol & Immunol, Chongqing, Peoples R China
11.Sun Yat Sen Univ, Affiliated Hosp 3, Dept Rheumatol & Immunol, Guangzhou 510275, Guangdong, Peoples R China
12.Zhejiang Univ, Affiliated Hosp 2, Dept Rheumatol & Immunol, Hangzhou 310003, Zhejiang, Peoples R China
13.Nanjing Univ, Sch Med, Nanjing Drum Tower Hosp, Dept Rheumatol & Immunol,Affiliated Hosp, Nanjing 210008, Jiangsu, Peoples R China
14.Sun Yat Sen Univ, Affiliated Hosp 1, Dept Rheumatol & Immunol, Guangzhou 510275, Guangdong, Peoples R China
15.Chinese Peoples Liberat Army Gen Hosp, Dept Rheumatol & Immunol, Beijing, Peoples R China
16.Second Mil Med Univ, Dept Rheumatol & Immunol, Shanghai, Peoples R China
17.Second Mil Med Univ, Changhai Hosp, Dept Rheumatol & Immunol, Shanghai, Peoples R China
18.Jiangsu Prov People Hosp, Dept Rheumatol & Immunol, Nanjing, Jiangsu, Peoples R China
19.Capital Univ Med Sci, Beijing Chaoyang Affiliated Hosp, Dept Rheumatol & Immunol, Beijing, Peoples R China

Recommended Citation:
Zhang, Xuewu,Zhang, Fengchun,Wu, Donghai,et al. Safety of infliximab therapy in rheumatoid arthritis patients with previous exposure to hepatitis B virus[J]. INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES,2013,16(4):408-412.
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