北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第一临床医学院  > 皮肤性病科  > 期刊论文
学科主题: 临床医学
题名:
Recalcitrant Primary Subcutaneous Phaeohyphomycosis Due to Phialophora verrucosa
作者: Gao, Lu-juan; Yu, Jin; Wang, Duan-li; Li, Ruo-yu
关键词: Phialophora verrucosa ; Phaeohyphomycosis ; Subcutaneous ; Recalcitrant
刊名: MYCOPATHOLOGIA
发表日期: 2013-02-01
DOI: 10.1007/s11046-012-9602-3
卷: 175, 期:1-2, 页:165-170
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Mycology
研究领域[WOS]: Mycology
关键词[WOS]: PATIENT ; CHROMOBLASTOMYCOSIS ; INFECTION
英文摘要:

Phialophora verrucosa has rarely been reported for causing phaeohyphomycosis, which tends to occur in immunocompromised individuals. The case of primary subcutaneous phaeohyphomycosis due to P. verrucosa in an otherwise healthy Chinese female is presented. The girl presented with asymptomatic skin lesions when she was only 16 year old. Histological examinations revealed multiple dematiceous hyphael elements in the dermis and subcutaneous tissues. Fungal cultures were identified as P. verrucosa repeatedly based on the morphological features and confirmed by the internal transcribed spacer region nucleotide sequencing. The infection was so extremely recalcitrant that prolonged systemic antifungal regimens for 12 years revealed limited effect. The skin lesions slowly progressed and caused marked disfigurement despite the encouraging results of in vitro susceptibility. However, no relevant side effects have been reported in the course, and the patient gave birth to a healthy baby while under the maintenance treatment of itraconazole and terbinafine. This case is special in terms of the early onset, the rare clinical aspect of the pathogen, the discrepancy between in vitro and in vivo antifungal activities and especially the prolonged and recalcitrant course in such an otherwise healthy host.

语种: 英语
所属项目编号: 200802026 ; 2008zx10004-002
项目资助者: Ministry of Health of China ; Ministry of Health of China ; Ministry of Science and Technology of China
WOS记录号: WOS:000313968100021
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61375
Appears in Collections:北京大学第一临床医学院_皮肤性病科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: Peking Univ, Dept Dermatol, Hosp 1, Res Ctr Med Mycol, Beijing 100034, Peoples R China

Recommended Citation:
Gao, Lu-juan,Yu, Jin,Wang, Duan-li,et al. Recalcitrant Primary Subcutaneous Phaeohyphomycosis Due to Phialophora verrucosa[J]. MYCOPATHOLOGIA,2013,175(1-2):165-170.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Gao, Lu-juan]'s Articles
[Yu, Jin]'s Articles
[Wang, Duan-li]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Gao, Lu-juan]‘s Articles
[Yu, Jin]‘s Articles
[Wang, Duan-li]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace