IR@PKUHSC  > 北京大学第一临床医学院  > 皮肤性病科
学科主题临床医学
Recalcitrant Primary Subcutaneous Phaeohyphomycosis Due to Phialophora verrucosa
Gao, Lu-juan; Yu, Jin; Wang, Duan-li; Li, Ruo-yu
关键词Phialophora verrucosa Phaeohyphomycosis Subcutaneous Recalcitrant
刊名MYCOPATHOLOGIA
2013-02-01
DOI10.1007/s11046-012-9602-3
175期:1-2页:165-170
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Mycology
研究领域[WOS]Mycology
关键词[WOS]PATIENT ; CHROMOBLASTOMYCOSIS ; INFECTION
英文摘要

Phialophora verrucosa has rarely been reported for causing phaeohyphomycosis, which tends to occur in immunocompromised individuals. The case of primary subcutaneous phaeohyphomycosis due to P. verrucosa in an otherwise healthy Chinese female is presented. The girl presented with asymptomatic skin lesions when she was only 16 year old. Histological examinations revealed multiple dematiceous hyphael elements in the dermis and subcutaneous tissues. Fungal cultures were identified as P. verrucosa repeatedly based on the morphological features and confirmed by the internal transcribed spacer region nucleotide sequencing. The infection was so extremely recalcitrant that prolonged systemic antifungal regimens for 12 years revealed limited effect. The skin lesions slowly progressed and caused marked disfigurement despite the encouraging results of in vitro susceptibility. However, no relevant side effects have been reported in the course, and the patient gave birth to a healthy baby while under the maintenance treatment of itraconazole and terbinafine. This case is special in terms of the early onset, the rare clinical aspect of the pathogen, the discrepancy between in vitro and in vivo antifungal activities and especially the prolonged and recalcitrant course in such an otherwise healthy host.

语种英语
WOS记录号WOS:000313968100021
项目编号200802026 ; 2008zx10004-002
资助机构Ministry of Health of China ; Ministry of Health of China ; Ministry of Science and Technology of China
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61375
专题北京大学第一临床医学院_皮肤性病科
作者单位Peking Univ, Dept Dermatol, Hosp 1, Res Ctr Med Mycol, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Gao, Lu-juan,Yu, Jin,Wang, Duan-li,et al. Recalcitrant Primary Subcutaneous Phaeohyphomycosis Due to Phialophora verrucosa[J]. MYCOPATHOLOGIA,2013,175(1-2):165-170.
APA Gao, Lu-juan,Yu, Jin,Wang, Duan-li,&Li, Ruo-yu.(2013).Recalcitrant Primary Subcutaneous Phaeohyphomycosis Due to Phialophora verrucosa.MYCOPATHOLOGIA,175(1-2),165-170.
MLA Gao, Lu-juan,et al."Recalcitrant Primary Subcutaneous Phaeohyphomycosis Due to Phialophora verrucosa".MYCOPATHOLOGIA 175.1-2(2013):165-170.
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