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学科主题: 基础医学
题名:
Mucinous carcinoma of the skin, primary, and secondary a clinicopathologic study of 63 cases with emphasis on the morphologic spectrum of primary cutaneous forms: Homologies with mucinous lesions in the breast
作者: Kazakov, DV; Suster, S; LeBoit, PE; Calonje, E; Bisceglia, M; Kutzner, H; Rutten, A; Mentzel, T; Schaller, J; Zelger, B; Baltaci, M; Leivo, I; Rose, C; Fukunaga, M; Simpson, RHW; Yang, Y; Carlson, JA; Cavazza, A; Hes, O; Mukensnabl, P; Vanecek, T; Fidalgo, A; Pizinger, K; Michal, M
关键词: mucinous carcinoma ; gelatinous carcinoma ; mucocelelike tumors ; in situ ; inverse cell polarity ; signet-ring cells ; globoid cells ; dirty necrosis ; HER-2/neu gene
刊名: AMERICAN JOURNAL OF SURGICAL PATHOLOGY
发表日期: 2005-06-01
卷: 29, 期:6, 页:764-782
收录类别: SCI ; ISTP
文章类型: Proceedings Paper
WOS标题词: Science & Technology
类目[WOS]: Pathology ; Surgery
研究领域[WOS]: Pathology ; Surgery
关键词[WOS]: SWEAT GLAND CARCINOMA ; ADENOCYSTIC CARCINOMA ; PAPILLARY-CARCINOMA ; ELECTRON-MICROSCOPY ; TUMORS ; EXPRESSION ; BENIGN ; TISSUE ; ADENOCARCINOMA ; METASTASIS
英文摘要:

We present the largest series of mucinous carcinoma involving the skin, describing the histopathologic, immunohistochemical, electron microscopic, and cytogenetic findings. Our aim was fully to characterize the clinicopathologic spectrum and compare it with that seen in the breast. In addition, we wished to reevaluate the differential diagnostic criteria for distinguishing primary mucinous carcinomas from histologically similar neoplasms involving the skin secondarily, and study some aspects of their pathogenesis. We demonstrate that primary cutaneous mucinous carcinomas span a morphologic spectrum compatible to their mammary counterparts. Both pure and mixed types can be delineated morphologically, and some lesions have mucocele-like configurations. Most lesions seem to originate from in situ lesions that may represent, using mammary pathology terminology, ductal hyperplasia, atypical ductal hyperplasia, or ductal carcinoma in situ or a combination of the three. Inverse cell polarity appears to facilitate the progression of the changes similar to lesions in the breast. The presence of an in situ component defines the neoplasm as primary cutaneous, but its absence does not exclude the diagnosis; although for such neoplasms, full clinical assessment is essential. Mammary mucinous carcinoma involving the skin: all patients presented with lesions on chest wall, breast, axilla, and these locations can serve as clue to the breast origin. Microscopically, cutaneous lesions were of both pure and mixed type, and this correlated with the primary in the breast. Dirty necrosis was a constant histologic finding in intestine mucinous carcinomas involving the skin, and this feature may serve as a clue to an intestinal origin.

语种: 英语
WOS记录号: WOS:000229348500006
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61376
Appears in Collections:基础医学院_病理学系_期刊论文

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作者单位: 1.Jikei 3rd Hosp, Dept Pathol, Tokyo, Japan
2.Albany Med Coll, Div Dermatopathol, Albany, NY 12208 USA
3.Hosp Desterro, Dept Dermatol, Lisbon, Portugal
4.Ohio State Univ, Dept Pathol, Med Ctr, Columbus, OH 43210 USA
5.Dermatohistopathol Gemeinschaftpraxis, Friedrichshafen, Germany
6.St Barbara Hosp, Dept Dermatol, Unit Dermatopathol, Duisburg, Germany
7.Med Univ Lubeck, Dept Dermatol, D-23538 Lubeck, Germany
8.Charles Univ Prague, Sikls Dept Pathol, Med Fac Hosp, Plzen 30460, Czech Republic
9.Univ Calif San Francisco, Dermatopathol Sect, San Francisco, CA 94143 USA
10.St Thomas Hosp, St Johns Inst Dermatol, Dept Dermatopathol, London, England
11.Osped Casa Sollievo Sofferenza, IRCCS, Dept Pathol, San Giovanni Rotondo, Italy
12.Med Univ Innsbruck, Clin Dept Dermatol & Venereol, Innsbruck, Austria
13.Univ Helsinki, Haartman Inst, Dept Pathol, FIN-00014 Helsinki, Finland
14.Royal Devon & Exeter Hosp, Dept Histopathol, Exeter EX2 5DW, Devon, England
15.Peking Univ, Hlth Sci Ctr, Dept Pathol, Beijing 100871, Peoples R China
16.Arcispedale S Maria Nuova, Dept Pathol, Reggio Emilia, Italy
17.Charles Univ Prague, Med Fac Hosp, Dept Dermatol, Plzen, Czech Republic

Recommended Citation:
Kazakov, DV,Suster, S,LeBoit, PE,et al. Mucinous carcinoma of the skin, primary, and secondary a clinicopathologic study of 63 cases with emphasis on the morphologic spectrum of primary cutaneous forms: Homologies with mucinous lesions in the breast[J]. AMERICAN JOURNAL OF SURGICAL PATHOLOGY,2005,29(6):764-782.
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