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Alloimmune Response Results in Expansion of Autoreactive Donor CD4(+) T Cells in Transplants That Can Mediate Chronic Graft-versus-Host Disease
Zhao, Dongchang1,2; Young, James S.1,2,3; Chen, Yu-Hong1,2,4,5; Shen, Elizabeth6; Yi, Tangsheng1,2; Todorov, Ivan1; Chu, Peiguo G.7; Forman, Stephen J.2; Zeng, Defu1,2,3
刊名JOURNAL OF IMMUNOLOGY
2011-01-15
DOI10.4049/jimmunol.1002195
186期:2页:856-868
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Immunology
资助者National Institutes of Health ; National Institutes of Health
研究领域[WOS]Immunology
关键词[WOS]BONE-MARROW-TRANSPLANTATION ; MINOR HISTOCOMPATIBILITY ANTIGENS ; AUTOIMMUNE MANIFESTATIONS ; NEPHROTIC SYNDROME ; RISK-FACTORS ; DE-NOVO ; MICE ; BLOOD ; REPERTOIRE ; GVHD
英文摘要

Chronic graft-versus-host disease (cGVHD) is considered an autoimmune-like disease mediated by donor CD4(+) T cells, but the origin of the autoreactive T cells is still controversial. In this article, we report that the transplantation of DBA/2 donor spleen cells into thymectomized MHC-matched allogeneic BALB/c recipients induced autoimmune-like cGVHD, although not in control syngeneic DBA/2 recipients. The donor-type CD4(+) T cells from the former but not the latter recipients induced autoimmune-like manifestations in secondary allogeneic BALB/c as well as syngeneic DBA/2 recipients. Transfer of donor-type CD4(+) T cells from secondary DBA/2 recipients with disease into syngeneic donor-type or allogeneic host-type tertiary recipients propagated autoimmune-like manifestations in both. Furthermore, TCR spectratyping revealed that the clonal expansion of the autoreactive CD4(+) T cells in cGVHD recipients was initiated by an alloimmune response. Finally, hybridoma CD4(+) T clones derived from DBA/2 recipients with disease proliferated similarly in response to stimulation by syngeneic donor-type or allogeneic host-type dendritic cells. These results demonstrate that the autoimmune-like manifestations in cGVHD can be mediated by a population of donor CD4(+) T cells in transplants that simultaneously recognize Ags presented by both donor and host APCs. The Journal of Immunology, 2011, 186: 856-868.

语种英语
所属项目编号R01-AI66008
资助者National Institutes of Health ; National Institutes of Health
WOS记录号WOS:000285917700025
引用统计
被引频次:23[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61379
专题北京大学第三临床医学院_血液内科
作者单位1.Peking Univ, Inst Hematol, Beijing 100871, Peoples R China
2.Peking Univ, Peoples Hosp, Beijing 100871, Peoples R China
3.City Hope Natl Med Ctr, Dept Pathol, Duarte, CA 91010 USA
4.City Hope Natl Med Ctr, Beckman Res Inst, Dept Diabet Res, Duarte, CA 91010 USA
5.City Hope Natl Med Ctr, Beckman Res Inst, Dept Hematol Hematopoiet Cell Transplantat, Duarte, CA 91010 USA
6.City Hope Natl Med Ctr, Irell & Manella Grad Sch Biol Sci, Duarte, CA 91010 USA
7.City Hope Natl Med Ctr, Eugene & Ruth Roberts Summer Student Acad, Duarte, CA 91010 USA
推荐引用方式
GB/T 7714
Zhao, Dongchang,Young, James S.,Chen, Yu-Hong,et al. Alloimmune Response Results in Expansion of Autoreactive Donor CD4(+) T Cells in Transplants That Can Mediate Chronic Graft-versus-Host Disease[J]. JOURNAL OF IMMUNOLOGY,2011,186(2):856-868.
APA Zhao, Dongchang.,Young, James S..,Chen, Yu-Hong.,Shen, Elizabeth.,Yi, Tangsheng.,...&Zeng, Defu.(2011).Alloimmune Response Results in Expansion of Autoreactive Donor CD4(+) T Cells in Transplants That Can Mediate Chronic Graft-versus-Host Disease.JOURNAL OF IMMUNOLOGY,186(2),856-868.
MLA Zhao, Dongchang,et al."Alloimmune Response Results in Expansion of Autoreactive Donor CD4(+) T Cells in Transplants That Can Mediate Chronic Graft-versus-Host Disease".JOURNAL OF IMMUNOLOGY 186.2(2011):856-868.
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