IR@PKUHSC  > 北京大学第一临床医学院
学科主题临床医学
Angiotensin II in atrial structural remodeling: the role of Ang II/JAK/STAT3 signaling pathway
Zheng, Liuying1; Jia, Xiaogang1; Zhang, Cheng1; Wang, Dong1; Cao, Zhongnan1; Wang, Jin2; Du, Xinping1
关键词Atrial fibrillation atrial structural remodeling angiotensin II STAT Ang II/JAK/STAT3 pathway
刊名AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
2015
7期:6页:1021-1031
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Medicine, Research & Experimental
资助者Tianjin Binhai New Area of Medical Science and Technology projects ; Tianjin Binhai New Area of Medical Science and Technology projects
研究领域[WOS]Oncology ; Research & Experimental Medicine
关键词[WOS]MATRIX METALLOPROTEINASES ; HEART-FAILURE ; MYOCARDIAL FIBROSIS ; FIBRILLATION ; FIBROBLASTS ; MECHANISMS ; MYOCYTES ; SURGERY
英文摘要

Ang II/JAK/STAT3 signaling pathway is known to be involved in atrial remodeling associated with development and progression of atrial fibrillation. In the present study, we used in vivo animal model and human atrial specimens to further characterize the role of this pathway in the atrial structural remodeling. We observed an elevated level of Ang II in the atrial samples of AF patients. This increase in Ang II was accompanied by increased expression of collagens I and III, MMP1, MMP2 and elevated phosphorylation of STAT3. Using rat models, we demonstrated that Ang II infusion induced profound changes in the level of apoptosis, expression of collagen subtypes I and III, caspase-3, caspase-8, MMP1, MMP2 and redistribution of cytochrome C. The data further support the key role of Ang II in the development of AF and highlight the specific mechanisms and changes associated with this process.

语种英语
所属项目编号2011BHKZ005
资助者Tianjin Binhai New Area of Medical Science and Technology projects ; Tianjin Binhai New Area of Medical Science and Technology projects
WOS记录号WOS:000358364100004
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61381
Collection北京大学第一临床医学院
作者单位1.Fifth Cent Hosp Tianjin, Tianjin 300450, Peoples R China
2.Peking Univ, Hosp 1, Beijing 100871, Peoples R China
Recommended Citation
GB/T 7714
Zheng, Liuying,Jia, Xiaogang,Zhang, Cheng,et al. Angiotensin II in atrial structural remodeling: the role of Ang II/JAK/STAT3 signaling pathway[J]. AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH,2015,7(6):1021-1031.
APA Zheng, Liuying.,Jia, Xiaogang.,Zhang, Cheng.,Wang, Dong.,Cao, Zhongnan.,...&Du, Xinping.(2015).Angiotensin II in atrial structural remodeling: the role of Ang II/JAK/STAT3 signaling pathway.AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH,7(6),1021-1031.
MLA Zheng, Liuying,et al."Angiotensin II in atrial structural remodeling: the role of Ang II/JAK/STAT3 signaling pathway".AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH 7.6(2015):1021-1031.
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