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学科主题: 临床医学
题名:
Expression of Eph receptor tyrosine kinases and their ligands in human granulosa lutein cells and human umbilical vein endothelial cells
作者: Xu, Y.; Zagoura, D.; Keck, C.; Pietrowski, D.
关键词: Eph ; ephrin ; granulosa cells ; receptor tyrosine kinase
刊名: EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
发表日期: 2006-11-01
DOI: 10.1055/s-2006-950499
卷: 114, 期:10, 页:590-595
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Endocrinology & Metabolism
研究领域[WOS]: Endocrinology & Metabolism
关键词[WOS]: EPHRINB LIGANDS ; ANGIOGENESIS ; PROLIFERATION ; GENE ; ACTIVATION ; PEPTIDE ; BINDING ; CANCER ; ROLES ; HCG
英文摘要:

Corpus luteum development is regulated by gonadotropins and accompanied by extremely rapid vascularization of the avascular granulosa cell compartiment by endothelial cells (EC). The proliferation of Granulosa cells (GC) and EC is a complex interplay and takes place in a spatially and temporarily coordinated manner. The erythropoietin-producing hepatoma amplified sequence (Eph) receptors and their ligands-the ephrins- are a recently detected family of membrane located protein tyrosine kinases which play a crucial role in the growth and development of nerve and blood vessel network. We report about the mRNA expression pattern of Ephs and their ligands in human GC, in human EC, and in carcinoma cell lines OvCar-3 and Hela. The mRNA of EphA4, EphA7, ephrinA4, ephrinB1 and ephrinB2 was detected in GC and EC, while EphA2 was expressed only in GC. The expression of various Ephs and ephrins did not change in GC after stimulation with human chorion gonadotropin. Our study analyzes for the first time the expression of the complete human Eph/ephrinysystem in GC and in EC. The remarkable similarity between these two cell types supports the theory of a functional relationship of EC and GC. In addition, it was shown that hCG is not a major determinant of Eph/ephrin regulation in GC.

语种: 英语
WOS记录号: WOS:000243186100009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61382
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: 1.Univ Athens, Sch Sci, Fac Biol, Athens, Greece
2.PAN Hosp, Div Gynecol Endocrinol & Reprod Med, Cologne, Germany
3.Beijing Univ, Hosp 1, Beijing, Peoples R China
4.Univ Freiburg, Med Ctr, Dept Obstet & Gynecol, D-7800 Freiburg, Germany

Recommended Citation:
Xu, Y.,Zagoura, D.,Keck, C.,et al. Expression of Eph receptor tyrosine kinases and their ligands in human granulosa lutein cells and human umbilical vein endothelial cells[J]. EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES,2006,114(10):590-595.
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