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学科主题: 药物依赖
题名:
Effects of Dehydroeffusol on Spasmogen-Induced Contractile Responses of Rat Intestinal Smooth Muscles
作者: Di, Fan1; Zhai, Haifeng2; Li, Peng1; Huang, Jianmei1
关键词: dehydroeffusol ; rat jejunum ; spasmolytic ; smooth muscle ; Juncus effusus ; Juncuaceae
刊名: PLANTA MEDICA
发表日期: 2014-08-01
DOI: 10.1055/s-0034-1382901
卷: 80, 期:12, 页:978-983
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Plant Sciences ; Pharmacology & Pharmacy
关键词[WOS]: PIG TAENIA-COLI ; GUINEA-PIG ; SCAPHYGLOTTIS-LIVIDA ; NITRIC-OXIDE ; IN-VITRO ; STILBENOIDS ; MOTILITY ; RECEPTOR ; PHENANTHRENES ; BAY-K-8644
英文摘要:

Dehydroeffusol is a naturally occurring phenanthrene isolated from Juncus effusus. In the context of screening new drugs against gastrointestinal spasms, we investigated its effects on isolated rat jejunum in vitro. Dehydroeffusol (30-90 mu M) slightly and transiently enhanced contractions in a concentration-dependent manner but significantly inhibited the contractions induced by KCl (100 mM), (+/-)-Bay-K8644 (5 mu M), pilocarpine (90 mu M), and histamine (100 mu M). These results show that dehydroeffusol may antagonize the spasmogenic activity of various agents, and therefore, could be a promising agent in the treatment of spasms. Its potential spasmolytic mechanism is also discussed.

语种: 英语
WOS记录号: WOS:000340904300004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61384
Appears in Collections:中国药物依赖性研究所_期刊论文

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作者单位: 1.Beijing Univ Chinese Med, Sch Chinese Mat Med, Beijing 100102, Peoples R China
2.Peking Univ, Natl Inst Drug Dependence, Beijing 100191, Peoples R China

Recommended Citation:
Di, Fan,Zhai, Haifeng,Li, Peng,et al. Effects of Dehydroeffusol on Spasmogen-Induced Contractile Responses of Rat Intestinal Smooth Muscles[J]. PLANTA MEDICA,2014,80(12):978-983.
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