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Effects of Dehydroeffusol on Spasmogen-Induced Contractile Responses of Rat Intestinal Smooth Muscles
Di, Fan1; Zhai, Haifeng2; Li, Peng1; Huang, Jianmei1
关键词dehydroeffusol rat jejunum spasmolytic smooth muscle Juncus effusus Juncuaceae
刊名PLANTA MEDICA
2014-08-01
DOI10.1055/s-0034-1382901
80期:12页:978-983
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]Plant Sciences ; Pharmacology & Pharmacy
关键词[WOS]PIG TAENIA-COLI ; GUINEA-PIG ; SCAPHYGLOTTIS-LIVIDA ; NITRIC-OXIDE ; IN-VITRO ; STILBENOIDS ; MOTILITY ; RECEPTOR ; PHENANTHRENES ; BAY-K-8644
英文摘要

Dehydroeffusol is a naturally occurring phenanthrene isolated from Juncus effusus. In the context of screening new drugs against gastrointestinal spasms, we investigated its effects on isolated rat jejunum in vitro. Dehydroeffusol (30-90 mu M) slightly and transiently enhanced contractions in a concentration-dependent manner but significantly inhibited the contractions induced by KCl (100 mM), (+/-)-Bay-K8644 (5 mu M), pilocarpine (90 mu M), and histamine (100 mu M). These results show that dehydroeffusol may antagonize the spasmogenic activity of various agents, and therefore, could be a promising agent in the treatment of spasms. Its potential spasmolytic mechanism is also discussed.

语种英语
WOS记录号WOS:000340904300004
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61384
专题中国药物依赖性研究所
北京大学精神卫生研究所_精神科
作者单位1.Beijing Univ Chinese Med, Sch Chinese Mat Med, Beijing 100102, Peoples R China
2.Peking Univ, Natl Inst Drug Dependence, Beijing 100191, Peoples R China
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GB/T 7714
Di, Fan,Zhai, Haifeng,Li, Peng,et al. Effects of Dehydroeffusol on Spasmogen-Induced Contractile Responses of Rat Intestinal Smooth Muscles[J]. PLANTA MEDICA,2014,80(12):978-983.
APA Di, Fan,Zhai, Haifeng,Li, Peng,&Huang, Jianmei.(2014).Effects of Dehydroeffusol on Spasmogen-Induced Contractile Responses of Rat Intestinal Smooth Muscles.PLANTA MEDICA,80(12),978-983.
MLA Di, Fan,et al."Effects of Dehydroeffusol on Spasmogen-Induced Contractile Responses of Rat Intestinal Smooth Muscles".PLANTA MEDICA 80.12(2014):978-983.
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