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Comparison of Tc-99m-3PRGD2 Integrin Receptor Imaging with Tc-99m-MDP Bone Scan in Diagnosis of Bone Metastasis in Patients with Lung Cancer: A Multicenter Study
Miao, Weibing1; Zheng, Shan1; Dai, Haojie2; Wang, Feng3; Jin, Xiaona4,5; Zhu, Zhaohui4,5; Jia, Bing6
刊名PLOS ONE
2014-10-22
DOI10.1371/journal.pone.0111221
9期:10
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]POSITRON-EMISSION-TOMOGRAPHY ; CYCLIC RGD DIMERS ; BREAST-CANCER ; TUMOR UPTAKE ; ALPHA(V)BETA(3) ; ANGIOGENESIS ; PHARMACOKINETICS ; F-18-GALACTO-RGD ; BIODISTRIBUTION ; TC-99M-NC100692
英文摘要

Purpose: Tc-99m-3PRGD2, a promising tracer targeting integrin receptor, may serve as a novel tumor-specific agent for single photon emission computed tomography (SPECT). A multi-center study was prospectively designed to evaluate the diagnostic accuracy of Tc-99m-3PRGD2 imaging for bone metastasis in patients with lung cancer in comparison with the conventional Tc-99m-MDP bone scan.

Methods: The patients underwent whole-body scan and chest tomography successively at both 1 h and 4 h after intravenous injection of 11.1 MBq/Kg Tc-99m-3PRGD2. Tc-99m-MDP whole-body bone scan was routinely performed within 1 week for comparison. Three experienced nuclear medicine physicians blindly read the Tc-99m-3PRGD2 and Tc-99m-MDP images. The final diagnosis was established based on the comprehensive assessment of all available data.

Results: A total of 44 patients (29 male, 59 +/- 10 years old) with suspected lung cancer were recruited from 4 centers. Eighty-nine bone lesions in 18 patients were diagnosed as metastases and 23 bone lesions in 9 patients were benign. In a lesion-based analysis, Tc-99m-3PRGD2 imaging demonstrated a sensitivity, specificity, and accuracy of 92.1%, 91.3%, and 92.0%, respectively. The corresponding diagnostic values for Tc-99m-MDP bone scan were 87.6%, 60.9%, and 82.1%, respectively in the same patients. Tc-99m-MDP bone scan had better contrast in most lesions, whereas the Tc-99m-3PRGD2 imaging seemed to be more effective to exclude pseudo-positive lesions and detect bone metastases without osteogenesis.

Conclusion: Tc-99m-3PRGD2 is a novel tumor-specific agent based on SPECT technology with a promising value in diagnosis of bone metastasis in patients with lung cancer.

语种英语
WOS记录号WOS:000343674800111
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61385
专题北京大学医药卫生分析中心
北京大学基础医学院
作者单位1.Fujian Med Univ, Affiliated Hosp 1, Dept Nucl Med, Fuzhou, Peoples R China
2.Beijing Tongren Hosp, Dept Nucl Med, Beijing, Peoples R China
3.Nanjing Med Univ, Affiliated Hosp 1, Dept Nucl Med, Nanjing, Jiangsu, Peoples R China
4.Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Nucl Med, Beijing 100730, Peoples R China
5.Peking Union Med Coll, Beijing 100021, Peoples R China
6.Peking Univ, Med Isotopes Res Ctr, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Miao, Weibing,Zheng, Shan,Dai, Haojie,et al. Comparison of Tc-99m-3PRGD2 Integrin Receptor Imaging with Tc-99m-MDP Bone Scan in Diagnosis of Bone Metastasis in Patients with Lung Cancer: A Multicenter Study[J]. PLOS ONE,2014,9(10).
APA Miao, Weibing.,Zheng, Shan.,Dai, Haojie.,Wang, Feng.,Jin, Xiaona.,...&Jia, Bing.(2014).Comparison of Tc-99m-3PRGD2 Integrin Receptor Imaging with Tc-99m-MDP Bone Scan in Diagnosis of Bone Metastasis in Patients with Lung Cancer: A Multicenter Study.PLOS ONE,9(10).
MLA Miao, Weibing,et al."Comparison of Tc-99m-3PRGD2 Integrin Receptor Imaging with Tc-99m-MDP Bone Scan in Diagnosis of Bone Metastasis in Patients with Lung Cancer: A Multicenter Study".PLOS ONE 9.10(2014).
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