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学科主题: 公共卫生
题名:
Comparison of Tc-99m-3PRGD2 Integrin Receptor Imaging with Tc-99m-MDP Bone Scan in Diagnosis of Bone Metastasis in Patients with Lung Cancer: A Multicenter Study
作者: Miao, Weibing1; Zheng, Shan1; Dai, Haojie2; Wang, Feng3; Jin, Xiaona4,5; Zhu, Zhaohui4,5; Jia, Bing6
刊名: PLOS ONE
发表日期: 2014-10-22
DOI: 10.1371/journal.pone.0111221
卷: 9, 期:10
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: POSITRON-EMISSION-TOMOGRAPHY ; CYCLIC RGD DIMERS ; BREAST-CANCER ; TUMOR UPTAKE ; ALPHA(V)BETA(3) ; ANGIOGENESIS ; PHARMACOKINETICS ; F-18-GALACTO-RGD ; BIODISTRIBUTION ; TC-99M-NC100692
英文摘要:

Purpose: Tc-99m-3PRGD2, a promising tracer targeting integrin receptor, may serve as a novel tumor-specific agent for single photon emission computed tomography (SPECT). A multi-center study was prospectively designed to evaluate the diagnostic accuracy of Tc-99m-3PRGD2 imaging for bone metastasis in patients with lung cancer in comparison with the conventional Tc-99m-MDP bone scan.

Methods: The patients underwent whole-body scan and chest tomography successively at both 1 h and 4 h after intravenous injection of 11.1 MBq/Kg Tc-99m-3PRGD2. Tc-99m-MDP whole-body bone scan was routinely performed within 1 week for comparison. Three experienced nuclear medicine physicians blindly read the Tc-99m-3PRGD2 and Tc-99m-MDP images. The final diagnosis was established based on the comprehensive assessment of all available data.

Results: A total of 44 patients (29 male, 59 +/- 10 years old) with suspected lung cancer were recruited from 4 centers. Eighty-nine bone lesions in 18 patients were diagnosed as metastases and 23 bone lesions in 9 patients were benign. In a lesion-based analysis, Tc-99m-3PRGD2 imaging demonstrated a sensitivity, specificity, and accuracy of 92.1%, 91.3%, and 92.0%, respectively. The corresponding diagnostic values for Tc-99m-MDP bone scan were 87.6%, 60.9%, and 82.1%, respectively in the same patients. Tc-99m-MDP bone scan had better contrast in most lesions, whereas the Tc-99m-3PRGD2 imaging seemed to be more effective to exclude pseudo-positive lesions and detect bone metastases without osteogenesis.

Conclusion: Tc-99m-3PRGD2 is a novel tumor-specific agent based on SPECT technology with a promising value in diagnosis of bone metastasis in patients with lung cancer.

语种: 英语
所属项目编号: 2010J01154 ; Z111107058811096 ; 81171369 ; 81171370 ; 81271614 ; 81071189 ; 81000625 ; 30900373 ; 30930030 ; 30870728 ; 30870725 ; 81125011 ; 2011CB707703 ; 2011YQ030114 ; 2012ZX09102301-018
项目资助者: Fujian Provincial Natural Science Foundation ; Capital Special Project for Featured Clinical Application ; National Natural Science Foundation of China (NSFC) projects ; Outstanding Youth Fund ; "973" project ; Ministry of Science and Technology of China
WOS记录号: WOS:000343674800111
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61385
Appears in Collections:北京大学医药卫生分析中心_期刊论文

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作者单位: 1.Fujian Med Univ, Affiliated Hosp 1, Dept Nucl Med, Fuzhou, Peoples R China
2.Beijing Tongren Hosp, Dept Nucl Med, Beijing, Peoples R China
3.Nanjing Med Univ, Affiliated Hosp 1, Dept Nucl Med, Nanjing, Jiangsu, Peoples R China
4.Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Nucl Med, Beijing 100730, Peoples R China
5.Peking Union Med Coll, Beijing 100021, Peoples R China
6.Peking Univ, Med Isotopes Res Ctr, Beijing 100871, Peoples R China

Recommended Citation:
Miao, Weibing,Zheng, Shan,Dai, Haojie,et al. Comparison of Tc-99m-3PRGD2 Integrin Receptor Imaging with Tc-99m-MDP Bone Scan in Diagnosis of Bone Metastasis in Patients with Lung Cancer: A Multicenter Study[J]. PLOS ONE,2014,9(10).
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