IR@PKUHSC  > 北京大学第三临床医学院
学科主题临床医学
A randomised, controlled comparison of low-dose polyethylene glycol 3350 plus electrolytes with ispaghula husk in the treatment of adults with chronic functional constipation
Wang, HJ; Liang, XM; Yu, ZL; Zhou, LY; Lin, SR; Geraint, M
刊名CLINICAL DRUG INVESTIGATION
2004
24期:10页:569-576
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
英文摘要

Objective: To compare the efficacy and safety of polyethylene glycol (PEG) 3350 plus electrolytes (PEG+E; Movicol((R))) with that of ispaghula husk (psyllium; Konsyl((R))) in the treatment of constipation.

Patients: Male or female adults with chronic functional constipation.

Methods: This was a randomised, controlled, open-label, parallel-group trial. Study treatment was either PEG+E 13.8g/sachet dissolved in water twice daily or ispaghula husk 3.5g/sachet dissolved in water twice daily for a period of 2 weeks. Assessments were at baseline and after 1 and 2 weeks′ therapy and by patient daily diary card. The primary outcome measures were weekly defaecation rate, stool consistency according to the Bristol Stool Form scale, time to first defaecation, and overall efficacy, which combined defaecation rate, stool consistency and difficulty on defaecation. Adverse effects were recorded and laboratory assessments were performed before and at the end of the treatment period.

Results: Sixty-three patients were randomised to each treatment group. Treatment was highly effective in 50/63 patients in the PEG+E group compared with 26/63 in the ispaghula husk group, and the overall efficacy rates were 92% and 73%, respectively (p = 0.005). PEG+E increased the mean weekly defaecation rate from 1. 18 (SD 0.77) at baseline to 7.95 (SD 3.49) after 1 week and 8.48 (SD 3.55) after 2 weeks. In the ispaghula husk group the mean weekly defaecation rate increased from 1.33 (SD 0.68) at baseline to 5.33 (SD 2.81) after 1 week and to 5.71 (SD 2.49) after 2 weeks. The treatment differences for defaecation rates were all statistically significant (p < 0.001). Two weeks of treatment with PEG+E or ispaghula husk normalised stools in 55/63 (87.3%) and 42/63 (66.7%) of patients (p < 0.001). The incidence of adverse effects did not differ between groups and none were serious or required any treatment. Laboratory evaluations found no adverse effect from either treatment.

Conclusion: The present study demonstrated that low-dose PEG 3350 plus electrolytes is more effective and more rapid in its onset of action than ispaghula husk, and is equally well tolerated.

语种英语
WOS记录号WOS:000224621500002
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61386
专题北京大学第三临床医学院
作者单位1.Norgine Ltd, Harefield UB9 6NS, Middx, England
2.Beijing Friendship Hosp, Beijing, Peoples R China
3.Peking Univ, Hosp 3, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Wang, HJ,Liang, XM,Yu, ZL,et al. A randomised, controlled comparison of low-dose polyethylene glycol 3350 plus electrolytes with ispaghula husk in the treatment of adults with chronic functional constipation[J]. CLINICAL DRUG INVESTIGATION,2004,24(10):569-576.
APA Wang, HJ,Liang, XM,Yu, ZL,Zhou, LY,Lin, SR,&Geraint, M.(2004).A randomised, controlled comparison of low-dose polyethylene glycol 3350 plus electrolytes with ispaghula husk in the treatment of adults with chronic functional constipation.CLINICAL DRUG INVESTIGATION,24(10),569-576.
MLA Wang, HJ,et al."A randomised, controlled comparison of low-dose polyethylene glycol 3350 plus electrolytes with ispaghula husk in the treatment of adults with chronic functional constipation".CLINICAL DRUG INVESTIGATION 24.10(2004):569-576.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Wang, HJ]的文章
[Liang, XM]的文章
[Yu, ZL]的文章
百度学术
百度学术中相似的文章
[Wang, HJ]的文章
[Liang, XM]的文章
[Yu, ZL]的文章
必应学术
必应学术中相似的文章
[Wang, HJ]的文章
[Liang, XM]的文章
[Yu, ZL]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。