IR@PKUHSC  > 北京大学第三临床医学院
学科主题临床医学
Shenfu decoction as adjuvant therapy for improving quality of life and hepatic dysfunction in patients with symptomatic chronic heart failure
Wei, Huamin1,2; Wu, Hongjin1; Yu, Wen3; Yan, Xu3,4; Zhang, Xiaoyu3
关键词Traditional Chinese medicine Heart failure Liver Clinical trials Shenfu decoction
刊名JOURNAL OF ETHNOPHARMACOLOGY
2015-07-01
DOI10.1016/j.jep.2015.04.016
169页:347-355
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Plant Sciences ; Chemistry, Medicinal ; Integrative & Complementary Medicine ; Pharmacology & Pharmacy
研究领域[WOS]Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine
关键词[WOS]INDUCED LIVER-INJURY ; PANAX-GINSENG ; OXIDATIVE STRESS ; HEPG2 CELLS ; RATS ; EXTRACT ; ANTIOXIDANT ; POPULATION ; ALKALOIDS ; MICE
英文摘要

Ethnopharmacological relevance: Shenfu decoction (SFD) is a water extract of the dried root or root stalk of Panax ginseng C. A. Mey (Asian ginseng) and the lateral root of Aconitum carmichaeli Debx (prepared by Fuzi, Heishunpian in Chinese). It has been used to treat heart failure for over a thousand years. The main active components of SFD, ginsenosides and higenamine, enhance heart contractility, increase the coronary blood supply, improve ischemic myocardial metabolism, scavenge free radicals and protect myocardial ultrastructure.

Aim of the study: To investigate the effect of SFD on quality of life (QOL) and hepatic function in symptomatic chronic heart failure (CHF) patients.

Materials and methods: Forty patients enrolled in the study were randomized into two groups: an SFD group (18 cases) and a control group (22 cases). All the patients received standard heart failure therapy, and the SFD group patients were also treated with Shenfu granules for 14 days as an adjunctive therapy. The effects of SFD on QOL, plasma alanine aminotransferase (ALT) level, cardiac function, left ventricular ejection fraction (LVEF) and tumor necrosis factor-alpha (TNF-alpha) level were studied. ALT threshold in hepatic injury are 21 U/L for men and 17 U/L for women.

Results: Minnesota Living with Heart Failure Questionnaire (MLHFQ) scores were improved by 35.27 +/- 10.72 vs. 23.87 +/- 11.96 in the SFD and control groups respectively (p <0.01). Subgroup analysis of the MLHFQ results demonstrated that both physical and emotional scores were significantly higher in the SFD group (21.00 +/- 5.66 vs. 16.75 +/- 6.25, p <0.05; 4.64 +/- 4.84 vs. 1.13 +/- 2.85, p <0.05). Circulating ALT was significantly decreased by SFD (133 IU/L vs. 0.6 IU/L, p <0.01). The grading of cardiac function and LVEF were increased by 1.6 +/- 0.5 vs. 1.1 +/- 0.3 and 18% +/- 13% vs. 8% +/- 8% in the SFD and control groups respectively (p <0.05 and p <0.05). The level of TNF-alpha declined more in SFD than control group (64.8 +/- 5.0 to 57.6 +/- 4.1, p <0.05; vs. 61.6 5.9 vs. 57.7 +/- 3.2. p >0.05).

Conclusion: Compared with standard heart failure treatment, oral SFD as an adjuvant therapy significantly improved QOL and hepatic injury in CHF patients. (C) 2015 Elsevier Ireland Ltd. All rights reserved.

语种英语
WOS记录号WOS:000356983000038
项目编号30672586
资助机构National Natural Science Foundation of China
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61396
专题北京大学第三临床医学院
作者单位1.Peking Univ, Haidian Sect, Beijing Haidian Hosp, Hosp 3, Beijing 100080, Peoples R China
2.China Acad Chinese Med Sci, Guanganmen Hosp, Beijing 100053, Peoples R China
3.Beijing Hosp Integrated Tradit & Western Med, Beijing 100039, Peoples R China
4.Postdoctoral Workstn Zhongguancun Haidian Sci Pk, Beijing 100195, Peoples R China
推荐引用方式
GB/T 7714
Wei, Huamin,Wu, Hongjin,Yu, Wen,et al. Shenfu decoction as adjuvant therapy for improving quality of life and hepatic dysfunction in patients with symptomatic chronic heart failure[J]. JOURNAL OF ETHNOPHARMACOLOGY,2015,169:347-355.
APA Wei, Huamin,Wu, Hongjin,Yu, Wen,Yan, Xu,&Zhang, Xiaoyu.(2015).Shenfu decoction as adjuvant therapy for improving quality of life and hepatic dysfunction in patients with symptomatic chronic heart failure.JOURNAL OF ETHNOPHARMACOLOGY,169,347-355.
MLA Wei, Huamin,et al."Shenfu decoction as adjuvant therapy for improving quality of life and hepatic dysfunction in patients with symptomatic chronic heart failure".JOURNAL OF ETHNOPHARMACOLOGY 169(2015):347-355.
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