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学科主题: 临床医学
题名:
Shenfu decoction as adjuvant therapy for improving quality of life and hepatic dysfunction in patients with symptomatic chronic heart failure
作者: Wei, Huamin1,2; Wu, Hongjin1; Yu, Wen3; Yan, Xu3,4; Zhang, Xiaoyu3
关键词: Traditional Chinese medicine ; Heart failure ; Liver ; Clinical trials ; Shenfu decoction
刊名: JOURNAL OF ETHNOPHARMACOLOGY
发表日期: 2015-07-01
DOI: 10.1016/j.jep.2015.04.016
卷: 169, 页:347-355
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Plant Sciences ; Chemistry, Medicinal ; Integrative & Complementary Medicine ; Pharmacology & Pharmacy
研究领域[WOS]: Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine
关键词[WOS]: INDUCED LIVER-INJURY ; PANAX-GINSENG ; OXIDATIVE STRESS ; HEPG2 CELLS ; RATS ; EXTRACT ; ANTIOXIDANT ; POPULATION ; ALKALOIDS ; MICE
英文摘要:

Ethnopharmacological relevance: Shenfu decoction (SFD) is a water extract of the dried root or root stalk of Panax ginseng C. A. Mey (Asian ginseng) and the lateral root of Aconitum carmichaeli Debx (prepared by Fuzi, Heishunpian in Chinese). It has been used to treat heart failure for over a thousand years. The main active components of SFD, ginsenosides and higenamine, enhance heart contractility, increase the coronary blood supply, improve ischemic myocardial metabolism, scavenge free radicals and protect myocardial ultrastructure.

Aim of the study: To investigate the effect of SFD on quality of life (QOL) and hepatic function in symptomatic chronic heart failure (CHF) patients.

Materials and methods: Forty patients enrolled in the study were randomized into two groups: an SFD group (18 cases) and a control group (22 cases). All the patients received standard heart failure therapy, and the SFD group patients were also treated with Shenfu granules for 14 days as an adjunctive therapy. The effects of SFD on QOL, plasma alanine aminotransferase (ALT) level, cardiac function, left ventricular ejection fraction (LVEF) and tumor necrosis factor-alpha (TNF-alpha) level were studied. ALT threshold in hepatic injury are 21 U/L for men and 17 U/L for women.

Results: Minnesota Living with Heart Failure Questionnaire (MLHFQ) scores were improved by 35.27 +/- 10.72 vs. 23.87 +/- 11.96 in the SFD and control groups respectively (p <0.01). Subgroup analysis of the MLHFQ results demonstrated that both physical and emotional scores were significantly higher in the SFD group (21.00 +/- 5.66 vs. 16.75 +/- 6.25, p <0.05; 4.64 +/- 4.84 vs. 1.13 +/- 2.85, p <0.05). Circulating ALT was significantly decreased by SFD (133 IU/L vs. 0.6 IU/L, p <0.01). The grading of cardiac function and LVEF were increased by 1.6 +/- 0.5 vs. 1.1 +/- 0.3 and 18% +/- 13% vs. 8% +/- 8% in the SFD and control groups respectively (p <0.05 and p <0.05). The level of TNF-alpha declined more in SFD than control group (64.8 +/- 5.0 to 57.6 +/- 4.1, p <0.05; vs. 61.6 5.9 vs. 57.7 +/- 3.2. p >0.05).

Conclusion: Compared with standard heart failure treatment, oral SFD as an adjuvant therapy significantly improved QOL and hepatic injury in CHF patients. (C) 2015 Elsevier Ireland Ltd. All rights reserved.

语种: 英语
所属项目编号: 30672586
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000356983000038
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61396
Appears in Collections:北京大学第三临床医学院_期刊论文

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作者单位: 1.Peking Univ, Haidian Sect, Beijing Haidian Hosp, Hosp 3, Beijing 100080, Peoples R China
2.China Acad Chinese Med Sci, Guanganmen Hosp, Beijing 100053, Peoples R China
3.Beijing Hosp Integrated Tradit & Western Med, Beijing 100039, Peoples R China
4.Postdoctoral Workstn Zhongguancun Haidian Sci Pk, Beijing 100195, Peoples R China

Recommended Citation:
Wei, Huamin,Wu, Hongjin,Yu, Wen,et al. Shenfu decoction as adjuvant therapy for improving quality of life and hepatic dysfunction in patients with symptomatic chronic heart failure[J]. JOURNAL OF ETHNOPHARMACOLOGY,2015,169:347-355.
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