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学科主题: 口腔医学
题名:
Force-induced Adrb2 in Periodontal Ligament Cells Promotes Tooth Movement
作者: Cao, H.1,2; Kou, X.1,2; Yang, R.1,2; Liu, D.1,2; Wang, X.1,2; Song, Y.1,2; Feng, L.1,2; He, D.1,2; Gan, Y.3; Zhou, Y.1,2
关键词: orthodontics ; biomechanical phenomena ; beta-2 adrenergic receptors ; sympathetic nervous system ; bone remodeling ; osteoclast
刊名: JOURNAL OF DENTAL RESEARCH
发表日期: 2014-11-01
DOI: 10.1177/0022034514551769
卷: 93, 期:11, 页:1163-1169
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Dentistry, Oral Surgery & Medicine
研究领域[WOS]: Dentistry, Oral Surgery & Medicine
关键词[WOS]: SYMPATHETIC-NERVOUS-SYSTEM ; CREST STEM-CELLS ; BONE-FORMATION ; ADAPTIVE RESPONSE ; STIMULATION ; EXPRESSION ; DELETION ; CYCLASE ; MICE ; CAMP
英文摘要:

The sympathetic nervous system (SNS) regulates bone resorption through -2 adrenergic receptor (Adrb2). In orthodontic tooth movement (OTM), mechanical force induces and regulates alveolar bone remodeling. Compressive force-associated osteoclast differentiation and alveolar bone resorption are the rate-limiting steps of tooth movement. However, whether mechanical force can activate Adrb2 and thus contribute to OTM remains unknown. In this study, orthodontic nickel-titanium springs were applied to the upper first molars of rats and Adrb1/2(-/-) mice to confirm the role of SNS and Adrb2 in OTM. The results showed that blockage of SNS activity in the jawbones of rats by means of superior cervical ganglion ectomy reduced OTM distance from 860 to 540 m after 14 d of force application. In addition, the injection of nonselective Adrb2 agonist isoproterenol activated the downstream signaling of SNS to accelerate OTM from 300 to 540 m after 7 d of force application. Adrb1/2(-/-) mice showed significantly reduced OTM distance (19.5 m) compared with the wild-type mice (107.6 m) after 7 d of force application. Histopathologic analysis showed that the number of Adrb2-positive cells increased in the compressive region of periodontal ligament after orthodontic force was applied on rats. Mechanistically, mechanical compressive force upregulated Adrb2 expression in primary-cultured human periodontal ligament cells (PDLCs) through the elevation of intracellular Ca2+ concentration. Activation of Adrb2 in PDLCs increased the RANKL/OPG ratio and promoted the peripheral blood mononuclear cell differentiation to osteoclasts in the cocultured system. Upregulation of Adrb2 in PDLCs promoted osteoclastogenesis, which accelerated OTM through Adrb2-enhanced bone resorption. In summary, this study suggests that mechanical force-induced Adrb2 activation in PDLCs contributes to SNS-regulated OTM.

语种: 英语
所属项目编号: 81300897 ; 2013DFB30360
项目资助者: National Natural Science Foundation of China ; International S&amp ; T cooperation program of China
WOS记录号: WOS:000343975100017
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61399
Appears in Collections:北京大学口腔医学院_牙周科_期刊论文

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作者单位: 1.Peking Univ, Sch & Hosp Stomatol, Dept Orthodont, Beijing 100871, Peoples R China
2.Peking Univ, Sch & Hosp Stomatol, Ctr Craniofacial Stem Cell Res & Regenerat, Beijing 100871, Peoples R China
3.Peking Univ, Sch & Hosp Stomatol, Ctr Temporomandibular Disorders & Orofacial Pain, Beijing 100871, Peoples R China

Recommended Citation:
Cao, H.,Kou, X.,Yang, R.,et al. Force-induced Adrb2 in Periodontal Ligament Cells Promotes Tooth Movement[J]. JOURNAL OF DENTAL RESEARCH,2014,93(11):1163-1169.
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