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学科主题: 药学
题名:
Biotransformation of phlorizin by human intestinal flora and inhibition of biotransformation products on tyrosinase activity
作者: Zhang, Li-Qin1; Yang, Xiu-Wei1; Zhang, You-Bo1; Zhai, Ya-Ya1; Xu, Wei1; Zhao, Bo1; Liu, Dai-Lin2; Yu, Hong-Jian2
关键词: Phlorizin ; Phloretin ; Human intestinal flora ; Biotransformation ; Tyrosinase
刊名: FOOD CHEMISTRY
发表日期: 2012-05-15
DOI: 10.1016/j.foodchem.2011.11.071
卷: 132, 期:2, 页:936-942
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Applied ; Food Science & Technology ; Nutrition & Dietetics
研究领域[WOS]: Chemistry ; Food Science & Technology ; Nutrition & Dietetics
关键词[WOS]: APPLE POMACE ; ANTIOXIDANT ; PHLORETIN ; PHLOROGLUCINOL ; POLYPHENOLS ; FLAVONOIDS ; COMPONENTS ; BACTERIA ; CIDER
英文摘要:

Phlorizin (1) was anaerobically incubated with human intestinal bacteria and five biotransformation products (2-6) were obtained. Their structures were elucidated as phloretin (2), phloroglucinol (3), phloretic acid (4), 2,3,4-trihydroxybenzenepropanoic acid (5), and phloretic acid methyl ester (6) on the basis of their spectroscopic data. Using high-performance liquid chromatography equipped with a diode array detector, chromatographic separation of 1-4 was performed on an analytical C-18 column. The time course of the biotransformation was studied to probe into the biotransformation mechanism of 1 by human intestinal flora. The abilities of isolated strains to transform 1 were also investigated in order to find an optimal transformation strain. In addition, the inhibitory activity of parent compound 1 and its three main biotransformation products 2-4 on mushroom tyrosinase was estimated. The result showed that 2 has better inhibitory effect on tyrosinase activity than 1. (C) 2011 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 2009ZX09301-010 ; 2006-0623 ; 2008-0120
项目资助者: National New Drug R D Program ; State Key Laboratory of Natural and Biomimetic Drugs (Peking University)
WOS记录号: WOS:000300475800036
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61400
Appears in Collections:北京大学药学院_天然药物学系_期刊论文

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作者单位: 1.Tianjin Jianfeng Nat Prod R&D Co Ltd, Tianjin 300457, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Dept Nat Med, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

Recommended Citation:
Zhang, Li-Qin,Yang, Xiu-Wei,Zhang, You-Bo,et al. Biotransformation of phlorizin by human intestinal flora and inhibition of biotransformation products on tyrosinase activity[J]. FOOD CHEMISTRY,2012,132(2):936-942.
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