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Biotransformation of phlorizin by human intestinal flora and inhibition of biotransformation products on tyrosinase activity
Zhang, Li-Qin1; Yang, Xiu-Wei1; Zhang, You-Bo1; Zhai, Ya-Ya1; Xu, Wei1; Zhao, Bo1; Liu, Dai-Lin2; Yu, Hong-Jian2
关键词Phlorizin Phloretin Human intestinal flora Biotransformation Tyrosinase
刊名FOOD CHEMISTRY
2012-05-15
DOI10.1016/j.foodchem.2011.11.071
132期:2页:936-942
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Applied ; Food Science & Technology ; Nutrition & Dietetics
资助者National New Drug R D Program ; State Key Laboratory of Natural and Biomimetic Drugs (Peking University) ; National New Drug R D Program ; State Key Laboratory of Natural and Biomimetic Drugs (Peking University)
研究领域[WOS]Chemistry ; Food Science & Technology ; Nutrition & Dietetics
关键词[WOS]APPLE POMACE ; ANTIOXIDANT ; PHLORETIN ; PHLOROGLUCINOL ; POLYPHENOLS ; FLAVONOIDS ; COMPONENTS ; BACTERIA ; CIDER
英文摘要

Phlorizin (1) was anaerobically incubated with human intestinal bacteria and five biotransformation products (2-6) were obtained. Their structures were elucidated as phloretin (2), phloroglucinol (3), phloretic acid (4), 2,3,4-trihydroxybenzenepropanoic acid (5), and phloretic acid methyl ester (6) on the basis of their spectroscopic data. Using high-performance liquid chromatography equipped with a diode array detector, chromatographic separation of 1-4 was performed on an analytical C-18 column. The time course of the biotransformation was studied to probe into the biotransformation mechanism of 1 by human intestinal flora. The abilities of isolated strains to transform 1 were also investigated in order to find an optimal transformation strain. In addition, the inhibitory activity of parent compound 1 and its three main biotransformation products 2-4 on mushroom tyrosinase was estimated. The result showed that 2 has better inhibitory effect on tyrosinase activity than 1. (C) 2011 Elsevier Ltd. All rights reserved.

语种英语
所属项目编号2009ZX09301-010 ; 2006-0623 ; 2008-0120
资助者National New Drug R D Program ; State Key Laboratory of Natural and Biomimetic Drugs (Peking University) ; National New Drug R D Program ; State Key Laboratory of Natural and Biomimetic Drugs (Peking University)
WOS记录号WOS:000300475800036
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61400
专题北京大学药学院_天然药物学系
作者单位1.Tianjin Jianfeng Nat Prod R&D Co Ltd, Tianjin 300457, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Dept Nat Med, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Li-Qin,Yang, Xiu-Wei,Zhang, You-Bo,et al. Biotransformation of phlorizin by human intestinal flora and inhibition of biotransformation products on tyrosinase activity[J]. FOOD CHEMISTRY,2012,132(2):936-942.
APA Zhang, Li-Qin.,Yang, Xiu-Wei.,Zhang, You-Bo.,Zhai, Ya-Ya.,Xu, Wei.,...&Yu, Hong-Jian.(2012).Biotransformation of phlorizin by human intestinal flora and inhibition of biotransformation products on tyrosinase activity.FOOD CHEMISTRY,132(2),936-942.
MLA Zhang, Li-Qin,et al."Biotransformation of phlorizin by human intestinal flora and inhibition of biotransformation products on tyrosinase activity".FOOD CHEMISTRY 132.2(2012):936-942.
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