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学科主题基础医学
FUNCTIONAL CHARACTERIZATION OF HUMAN KINDLIN-2 CORE PROMOTER IDENTIFIES A KEY ROLE OF SP1 IN KINDLIN-2 TRANSCRIPTIONAL REGULATION
Khan, Ammad Aslam1; Shimokawa, Takashi1; Stromblad, Staffan1; Zhang, Hongquan1,2,3
关键词Kindlin-2 FERMT2 PLEKHC1 Mig-2 Transcription factor SP1 Promoter Transcription start site Gene regulation Cis-acting elements CpG island Cell migration Integrin Gene expression
刊名CELLULAR & MOLECULAR BIOLOGY LETTERS
2011-12-01
DOI10.2478/s11658-011-0028-6
16期:4页:638-651
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Cell Biology
资助者Swedish Cancer Society ; Swedish Society of Medicine ; Swedish Research Council ; Natural Science Foundation of China ; Ministry of Science and Technology of China ; Peking University ; Center for Bioscience at Karolinska Institutet ; Higher Education Commission of Pakistan ; Swedish Cancer Society ; Swedish Society of Medicine ; Swedish Research Council ; Natural Science Foundation of China ; Ministry of Science and Technology of China ; Peking University ; Center for Bioscience at Karolinska Institutet ; Higher Education Commission of Pakistan
研究领域[WOS]Biochemistry & Molecular Biology ; Cell Biology
关键词[WOS]CELL-MATRIX ADHESION ; INTEGRIN ; LOCALIZATION ; ACTIVATION ; COMPONENT ; UNC-112 ; PROTEIN ; LENGTH ; MOUSE
英文摘要

Kindlin-2 is a recently identified FERM and PH domain containing integrin interacting protein. Kindlin-2 is ubiquitously expressed in normal tissues. So far, much effort has been spent exploring the functional aspects of Kindlin-2. However, the transcriptional regulation of Kindlin-2 has not yet been investigated. In this study we identified and functionally characterized the promoter of the human Kindlin-2 gene. We show that the core promoter of Kindlin-2 is a 39 base pair long GC rich fragment located -122/-83 upstream of the Kindlin-2 transcription start site. Functional characterization of this core promoter region by both in silico as well as in vitro/in vivo analysis shows that the transcription factor SP1 plays an important role in regulation of Kindlin-2 expression.

语种英语
所属项目编号30830048 ; 2010CB912203 ; 2010CB529402
资助者Swedish Cancer Society ; Swedish Society of Medicine ; Swedish Research Council ; Natural Science Foundation of China ; Ministry of Science and Technology of China ; Peking University ; Center for Bioscience at Karolinska Institutet ; Higher Education Commission of Pakistan ; Swedish Cancer Society ; Swedish Society of Medicine ; Swedish Research Council ; Natural Science Foundation of China ; Ministry of Science and Technology of China ; Peking University ; Center for Bioscience at Karolinska Institutet ; Higher Education Commission of Pakistan
WOS记录号WOS:000298317500008
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61401
专题基础医学院
作者单位1.Karolinska Inst, Dept Biosci & Nutr, Ctr Biosci, Novum, S-14183 Huddinge, Sweden
2.Peking Univ, Sch Basic Med Sci, Lab Mol Cell Biol & Tumor Biol, Beijing 100191, Peoples R China
3.Minist Educ, Key Lab Carcinogenesis & Translat Res, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Khan, Ammad Aslam,Shimokawa, Takashi,Stromblad, Staffan,et al. FUNCTIONAL CHARACTERIZATION OF HUMAN KINDLIN-2 CORE PROMOTER IDENTIFIES A KEY ROLE OF SP1 IN KINDLIN-2 TRANSCRIPTIONAL REGULATION[J]. CELLULAR & MOLECULAR BIOLOGY LETTERS,2011,16(4):638-651.
APA Khan, Ammad Aslam,Shimokawa, Takashi,Stromblad, Staffan,&Zhang, Hongquan.(2011).FUNCTIONAL CHARACTERIZATION OF HUMAN KINDLIN-2 CORE PROMOTER IDENTIFIES A KEY ROLE OF SP1 IN KINDLIN-2 TRANSCRIPTIONAL REGULATION.CELLULAR & MOLECULAR BIOLOGY LETTERS,16(4),638-651.
MLA Khan, Ammad Aslam,et al."FUNCTIONAL CHARACTERIZATION OF HUMAN KINDLIN-2 CORE PROMOTER IDENTIFIES A KEY ROLE OF SP1 IN KINDLIN-2 TRANSCRIPTIONAL REGULATION".CELLULAR & MOLECULAR BIOLOGY LETTERS 16.4(2011):638-651.
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