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学科主题: 基础医学
题名:
FUNCTIONAL CHARACTERIZATION OF HUMAN KINDLIN-2 CORE PROMOTER IDENTIFIES A KEY ROLE OF SP1 IN KINDLIN-2 TRANSCRIPTIONAL REGULATION
作者: Khan, Ammad Aslam1; Shimokawa, Takashi1; Stromblad, Staffan1; Zhang, Hongquan1,2,3
关键词: Kindlin-2 ; FERMT2 ; PLEKHC1 ; Mig-2 ; Transcription factor SP1 ; Promoter ; Transcription start site ; Gene regulation ; Cis-acting elements ; CpG island ; Cell migration ; Integrin ; Gene expression
刊名: CELLULAR & MOLECULAR BIOLOGY LETTERS
发表日期: 2011-12-01
DOI: 10.2478/s11658-011-0028-6
卷: 16, 期:4, 页:638-651
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Cell Biology
研究领域[WOS]: Biochemistry & Molecular Biology ; Cell Biology
关键词[WOS]: CELL-MATRIX ADHESION ; INTEGRIN ; LOCALIZATION ; ACTIVATION ; COMPONENT ; UNC-112 ; PROTEIN ; LENGTH ; MOUSE
英文摘要:

Kindlin-2 is a recently identified FERM and PH domain containing integrin interacting protein. Kindlin-2 is ubiquitously expressed in normal tissues. So far, much effort has been spent exploring the functional aspects of Kindlin-2. However, the transcriptional regulation of Kindlin-2 has not yet been investigated. In this study we identified and functionally characterized the promoter of the human Kindlin-2 gene. We show that the core promoter of Kindlin-2 is a 39 base pair long GC rich fragment located -122/-83 upstream of the Kindlin-2 transcription start site. Functional characterization of this core promoter region by both in silico as well as in vitro/in vivo analysis shows that the transcription factor SP1 plays an important role in regulation of Kindlin-2 expression.

语种: 英语
所属项目编号: 30830048 ; 2010CB912203 ; 2010CB529402
项目资助者: Swedish Cancer Society ; Swedish Society of Medicine ; Swedish Research Council ; Natural Science Foundation of China ; Ministry of Science and Technology of China ; Peking University ; Center for Bioscience at Karolinska Institutet ; Higher Education Commission of Pakistan
WOS记录号: WOS:000298317500008
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61401
Appears in Collections:基础医学院_期刊论文

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作者单位: 1.Karolinska Inst, Dept Biosci & Nutr, Ctr Biosci, Novum, S-14183 Huddinge, Sweden
2.Peking Univ, Sch Basic Med Sci, Lab Mol Cell Biol & Tumor Biol, Beijing 100191, Peoples R China
3.Minist Educ, Key Lab Carcinogenesis & Translat Res, Beijing 100191, Peoples R China

Recommended Citation:
Khan, Ammad Aslam,Shimokawa, Takashi,Stromblad, Staffan,et al. FUNCTIONAL CHARACTERIZATION OF HUMAN KINDLIN-2 CORE PROMOTER IDENTIFIES A KEY ROLE OF SP1 IN KINDLIN-2 TRANSCRIPTIONAL REGULATION[J]. CELLULAR & MOLECULAR BIOLOGY LETTERS,2011,16(4):638-651.
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