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Inflammatory myofibroblastic tumor with RANBP2 and ALK gene rearrangement: a report of two cases and literature review
Li, Jian1; Yin, Wei-hua1; Takeuchi, Kengo2,3; Guan, Hong4; Huang, Yu-hua4; Chan, John K. C.5
关键词Inflammatory myofibroblastic tumor RANBP2-ALK Fluorescence in situ hybridization
刊名DIAGNOSTIC PATHOLOGY
2013-09-13
DOI10.1186/1746-1596-8-147
8
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Pathology
研究领域[WOS]Pathology
关键词[WOS]EXPRESSION ; FUSION ; FEATURES ; MUTATION ; CLTC ; P80
英文摘要

Inflammatory myofibroblastic tumors (IMTs) are categorized as intermediate biologic neoplasms, whereas IMTs with genetic features of ran-binding protein 2 (RANBP2) and anaplastic lymphoma kinase (ALK) rearrangement (IMT-RAs) are possibly related to a more aggressive clinical course. However, fewer than 10 cases of IMT-RA have been reported to date. Herein, we present 2 new cases of IMT-RA in which both tumors recurred quickly after primary surgery; one patient died 3 months later from the disease, and the other patient has been living with the disease for 12 months. IMT-RAs are characterized by noncohesive epithelioid and rounded tumoral cell morphology, commonly derived from pelvic and peritoneal cavities, and frequently show larger tumor sizes. The relation between the clinicopathologic features and poor prognosis of IMT-RA is discussed.

Virtual slides: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/3314123381007714

语种英语
WOS记录号WOS:000325380100001
引用统计
被引频次:21[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61406
专题北京大学深圳医院_病理科
作者单位1.Queen Elizabeth Hosp, Dept Pathol, Hong Kong, Hong Kong, Peoples R China
2.Peking Univ, Shenzhen Hosp, Dept Pathol, Shenzhen 518000, Peoples R China
3.Inst Canc Res, Pathol Project Mol Targets, Tokyo 1358550, Japan
4.Japanese Fdn Canc Res, Inst Canc, Div Pathol, Tokyo 1358550, Japan
5.Second Shenzhen Peoples Hosp, Dept Pathol, Shenzhen 518035, Peoples R China
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GB/T 7714
Li, Jian,Yin, Wei-hua,Takeuchi, Kengo,et al. Inflammatory myofibroblastic tumor with RANBP2 and ALK gene rearrangement: a report of two cases and literature review[J]. DIAGNOSTIC PATHOLOGY,2013,8.
APA Li, Jian,Yin, Wei-hua,Takeuchi, Kengo,Guan, Hong,Huang, Yu-hua,&Chan, John K. C..(2013).Inflammatory myofibroblastic tumor with RANBP2 and ALK gene rearrangement: a report of two cases and literature review.DIAGNOSTIC PATHOLOGY,8.
MLA Li, Jian,et al."Inflammatory myofibroblastic tumor with RANBP2 and ALK gene rearrangement: a report of two cases and literature review".DIAGNOSTIC PATHOLOGY 8(2013).
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