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学科主题: 临床医学
题名:
Role of contrast-enhanced ultrasonography in percutaneous radiofrequency ablation of liver metastases and efficacy evaluation
作者: Wu, Jie; Yang, Wei; Yin, Shanshan; Wu, Jinyu; Wu, Wei; Yan, Kun; Chen, Minhua
关键词: Contrast media ; liver metastases ; radiofrequency ablation ; ultrasonography
刊名: CHINESE JOURNAL OF CANCER RESEARCH
发表日期: 2013-04-01
DOI: 10.3978/j.issn.1000-9604.2013.01.02
卷: 25, 期:2, 页:143-154
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: HEPATIC COLORECTAL METASTASES ; RADIO-FREQUENCY ABLATION ; LONG-TERM SURVIVAL ; HEPATOCELLULAR-CARCINOMA ; HARMONIC SONOGRAPHY ; INITIAL-EXPERIENCE ; SURGICAL MARGIN ; 5-YEAR SURVIVAL ; ULTRASOUND ; RESECTION
英文摘要:

Objective: To retrospectively investigate the role of contrast-enhanced ultrasonography (CEUS) in percutaneous radiofrequency ablation (RFA) in patients with liver metastases and evaluate the therapeutic efficacy of RFA assisted by CEUS.

Methods: From May 2004 to September 2010, 136 patients with 219 liver metastatic lesions received CEUS examination 1 h before RFA (CEUS group), and other 126 patients with 216 lesions without CEUS examination in the earlier period were served as a historical control group. The mean tumor size was 3.2 cm and the mean tumor number was 1.6 in the CEUS group, while 3.4 cm and 1.7 in. the control group, respectively (P>0.05). The clinical characteristics, recurrence results and survival outcomes were compared between two groups.

Results: In the CEUS group, two isoechoic tumors were not demonstrated on unenhanced ultrasonography (US), and 63(47%) of 134 tumors examined with CEUS were 0.3 cm larger than with unenhanced US. Furthermore, in 18.4% of 136 patients, additional 1-3 tumors were detected on CEUS. The CEUS group showed higher early tumor necrosis and lower intrahepatic recurrence than the control group. The 3-year overall survival (OS) rate and the 3-year local recurrence-free survival (LRFS) rate in the CEUS group were 50.1% and 38.3%, in contrast to 25.3% and 19.3% in the control group, respectively (P=0.002 and P<0.001).

Conclusions: CEUS provides important information for RFA treatment in patients with liver metastases and better therapeutic effect could be attained.

语种: 英语
所属项目编号: 2009AA02Z4B8 ; Z11110706730000
项目资助者: Chinese National High Technology Research and Development Program 863 ; Project of the Capital Public Health Cultivation
WOS记录号: WOS:000318377200005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61407
Appears in Collections:北京大学临床肿瘤学院_超声科_期刊论文

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作者单位: Peking Univ, Canc Hosp & Inst, Dept Ultrasound, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China

Recommended Citation:
Wu, Jie,Yang, Wei,Yin, Shanshan,et al. Role of contrast-enhanced ultrasonography in percutaneous radiofrequency ablation of liver metastases and efficacy evaluation[J]. CHINESE JOURNAL OF CANCER RESEARCH,2013,25(2):143-154.
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