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Synthetic phenylethanoid glycoside derivatives as potent neuroprotective agents
Liu, Ying-Guo1; Li, Xiaxi1; Xiong, De-Cai1; Yu, Binhan1; Pu, Xiaoping1; Ye, Xin-Shan1,2
关键词Phenylethanoid glycoside Neuroprotective agent Structure modification Antioxidant Anti-apoptosis
刊名EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
2015-05-05
DOI10.1016/j.ejmech.2015.03.038
95页:313-323
收录类别SCI ; IC
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Medicinal
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]NEURONAL PC12 CELLS ; RADICAL SCAVENGER ; OXIDATIVE STRESS ; SIALIC-ACID ; 1-METHYL-4-PHENYLPYRIDINIUM ION ; PHENYLPROPANOID GLYCOSIDES ; NEURODEGENERATIVE DISEASE ; OLIGOSACCHARIDE SYNTHESIS ; BIOLOGICAL EVALUATION ; INDUCED APOPTOSIS
英文摘要

Several phenylethanoid glycoside derivatives were designed and synthesized. Most of the synthetic compounds showed significant neuroprotective effects, including antioxidative and anti-apoptotic properties. Specifically, target compounds displayed potent effects against various toxicities such as H2O2 and 6-hydroxydopamine (6-OHDA) in PCl2 cells. Among the synthetic derivatives, three compounds (5, 6, 8) exhibited much superior activities to the marketed drug Edaravone. The compounds were able to prevent the 6-OHDA-induced damage in PCl2 cells in a dose-dependent manner. The antiapoptotic effects could be observed via cell morphological changes. Moreover, the compounds significantly reduced the intracellular ROS increase resulting from 6-OHDA treatment. The preliminary structure activity relationships were also explored. Compounds 5, 6, 8 may hold the potential as promising neuroprotective agents and new lead compounds for the treatment of neurodegenerative diseases or cerebral ischemia. (C) 2015 Elsevier Masson SAS. All rights reserved.

语种英语
WOS记录号WOS:000354139900027
项目编号2012CB822100 ; 2013CB910700 ; 2012ZX09502001-001 ; 2012ZX09103301-048 ; 2012ZX09103201-042 ; 21232002
资助机构Ministry of Science and Technology of China ; National Natural Science Foundation of China
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61409
专题北京大学药学院
北京大学药学院_天然药物与仿生药物国家重点实验室
北京大学药学院_药物化学系
北京大学药学院_分子与细胞药理学系
作者单位1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Jiangxi Normal Univ, Natl Engn Res Ctr Carbohydrate Synth, Nanchang 330022, Jiangxi, Peoples R China
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GB/T 7714
Liu, Ying-Guo,Li, Xiaxi,Xiong, De-Cai,et al. Synthetic phenylethanoid glycoside derivatives as potent neuroprotective agents[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2015,95:313-323.
APA Liu, Ying-Guo,Li, Xiaxi,Xiong, De-Cai,Yu, Binhan,Pu, Xiaoping,&Ye, Xin-Shan.(2015).Synthetic phenylethanoid glycoside derivatives as potent neuroprotective agents.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,95,313-323.
MLA Liu, Ying-Guo,et al."Synthetic phenylethanoid glycoside derivatives as potent neuroprotective agents".EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 95(2015):313-323.
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